GenomeNet

Database: UniProt
Entry: SANT_PLAF7
LinkDB: SANT_PLAF7
Original site: SANT_PLAF7 
ID   SANT_PLAF7              Reviewed;         585 AA.
AC   Q03400; Q8IJ57;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   02-JUN-2021, entry version 88.
DE   RecName: Full=S-antigen protein;
DE   Flags: Precursor;
GN   ORFNames=PF10_0343;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1474992; DOI=10.1016/0166-6851(92)90161-c;
RA   Bickle Q.D., Coppel R.;
RT   "A fourth family of the Plasmodium falciparum S-antigen.";
RL   Mol. Biochem. Parasitol. 56:141-150(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
CC   -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC       sera of some infected individuals.
CC   -!- SUBCELLULAR LOCATION: Parasitophorous vacuole.
CC   -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC       the repetitive regions.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M81799; AAA29761.1; -; mRNA.
DR   EMBL; AE014185; AAN35540.1; -; Genomic_DNA.
DR   PIR; A48459; A48459.
DR   RefSeq; XP_001347627.1; XM_001347591.1.
DR   SMR; Q03400; -.
DR   PRIDE; Q03400; -.
DR   EnsemblProtists; CZT98609; CZT98609; PF3D7_1035200.
DR   GeneDB; PF3D7_1035200.1:pep; -.
DR   GeneID; 810500; -.
DR   KEGG; pfa:PF3D7_1035200; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1035200; -.
DR   HOGENOM; CLU_466535_0_0_1; -.
DR   InParanoid; Q03400; -.
DR   OMA; QGTEQGT; -.
DR   PhylomeDB; Q03400; -.
DR   GO; GO:0020003; C:symbiont-containing vacuole; TAS:GeneDB.
DR   InterPro; IPR008825; S-antigen.
DR   Pfam; PF05756; S-antigen; 1.
PE   2: Evidence at transcript level;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..585
FT                   /note="S-antigen protein"
FT                   /id="PRO_0000024626"
FT   REPEAT          102..109
FT                   /note="1"
FT   REPEAT          110..117
FT                   /note="2"
FT   REPEAT          118..125
FT                   /note="3"
FT   REPEAT          126..133
FT                   /note="4"
FT   REPEAT          134..141
FT                   /note="5"
FT   REPEAT          142..149
FT                   /note="6"
FT   REPEAT          150..157
FT                   /note="7"
FT   REPEAT          158..165
FT                   /note="8"
FT   REPEAT          166..173
FT                   /note="9"
FT   REPEAT          174..181
FT                   /note="10"
FT   REPEAT          182..189
FT                   /note="11"
FT   REPEAT          190..197
FT                   /note="12"
FT   REPEAT          198..205
FT                   /note="13"
FT   REPEAT          206..213
FT                   /note="14"
FT   REPEAT          214..221
FT                   /note="15"
FT   REPEAT          222..229
FT                   /note="16"
FT   REPEAT          230..237
FT                   /note="17"
FT   REPEAT          238..245
FT                   /note="18"
FT   REPEAT          246..253
FT                   /note="19"
FT   REPEAT          254..261
FT                   /note="20"
FT   REPEAT          262..269
FT                   /note="21"
FT   REPEAT          270..277
FT                   /note="22"
FT   REPEAT          278..285
FT                   /note="23"
FT   REPEAT          286..293
FT                   /note="24"
FT   REPEAT          294..301
FT                   /note="25"
FT   REPEAT          302..309
FT                   /note="26"
FT   REPEAT          310..317
FT                   /note="27"
FT   REPEAT          318..325
FT                   /note="28"
FT   REPEAT          326..333
FT                   /note="29"
FT   REPEAT          334..341
FT                   /note="30"
FT   REPEAT          342..349
FT                   /note="31"
FT   REPEAT          350..357
FT                   /note="32"
FT   REPEAT          358..365
FT                   /note="33"
FT   REPEAT          366..373
FT                   /note="34"
FT   REPEAT          374..381
FT                   /note="35"
FT   REPEAT          382..389
FT                   /note="36"
FT   REPEAT          390..397
FT                   /note="37"
FT   REPEAT          398..405
FT                   /note="38"
FT   REPEAT          406..413
FT                   /note="39"
FT   REPEAT          414..421
FT                   /note="40"
FT   REPEAT          422..429
FT                   /note="41"
FT   REPEAT          430..437
FT                   /note="42"
FT   REPEAT          438..445
FT                   /note="43"
FT   REPEAT          446..453
FT                   /note="44"
FT   REPEAT          454..461
FT                   /note="45"
FT   REPEAT          462..469
FT                   /note="46"
FT   REPEAT          470..477
FT                   /note="47"
FT   REPEAT          478..485
FT                   /note="48"
FT   REPEAT          486..493
FT                   /note="49"
FT   REPEAT          494..501
FT                   /note="50"
FT   REPEAT          502..509
FT                   /note="51"
FT   REPEAT          510..517
FT                   /note="52"
FT   REPEAT          518..525
FT                   /note="53"
FT   REPEAT          526..533
FT                   /note="54"
FT   REPEAT          534..541
FT                   /note="55"
FT   REPEAT          542..549
FT                   /note="56"
FT   REGION          51..585
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..549
FT                   /note="56 X 8 AA tandem repeats of E-D-[EK]-V-S-N-G-[RG]"
FT   COMPBIAS        62..81
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..469
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..573
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        101
FT                   /note="S -> T (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        280
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        328
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        368
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        408
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        448
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        456
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        536
FT                   /note="K -> E (in Ref. 1; AAA29761)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        551
FT                   /note="D -> DEVSNGRED (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   585 AA;  62947 MW;  318A9ABB83711A28 CRC64;
     MNRILSVTLC LFFIYLYIYK TYGKVKNTDE GLSNIYGAKY YLRSGLFNEK NGKGQKYEDL
     EEEKEGENDD EEDSNSEESN NDEENELIKG QEGVEQETHG SEDEVSNGRE DKVSNGGEDE
     VSNGGEDEVS NGREDKVSNG GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGGEDEVSNG
     REDKVSNGGE DEVSNGREDK VSNGREDKVS NGGEDEVSNG REDKVSNGRE DKVSNGGEDE
     VSNGREDKVS NGGEDEVSNG REDKVSNGGE DEVSNGREDK VSNGREDEVS NGREDKVSNG
     GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG GEDEVSNGRE DKVSNGGEDE
     VSNGREDKVS NGREDKVSNG REDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG
     GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG REDKVSNGGE DEVSNGGEDE
     VSNGREDKVS NGGEDEVSNG REDKVSNGGE DEVSNGREDK VSNGGEDEVS NGREDKVSNG
     REDEVSNGRE DKGGAGTDGE LSHNSESHTK NKKSKNSIIN MLIGM
//
DBGET integrated database retrieval system