ID SOCS4_PONAB Reviewed; 440 AA.
AC Q5RDX2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 18-JUN-2025, entry version 95.
DE RecName: Full=Suppressor of cytokine signaling 4;
DE Short=SOCS-4;
GN Name=SOCS4;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: SOCS family proteins form part of a classical negative
CC feedback system that regulates cytokine signal transduction. Substrate-
CC recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Inhibits EGF signaling by mediating the degradation of the
CC Tyr-phosphorylated EGF receptor/EGFR (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
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DR EMBL; CR857770; CAH90035.1; -; mRNA.
DR RefSeq; NP_001124969.1; NM_001131497.1.
DR AlphaFoldDB; Q5RDX2; -.
DR SMR; Q5RDX2; -.
DR FunCoup; Q5RDX2; 436.
DR STRING; 9601.ENSPPYP00000006629; -.
DR GeneID; 100171842; -.
DR KEGG; pon:100171842; -.
DR CTD; 122809; -.
DR eggNOG; KOG4566; Eukaryota.
DR InParanoid; Q5RDX2; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Reference proteome; SH2 domain;
KW Signal transduction inhibitor; Ubl conjugation pathway.
FT CHAIN 1..440
FT /note="Suppressor of cytokine signaling 4"
FT /id="PRO_0000285845"
FT DOMAIN 286..381
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 376..425
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..10
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 50534 MW; 025CCF83DEDA1BC2 CRC64;
MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQAE LKDGQLKRRN
MEESINCFSH TNVQPCVITT DNALCREGPI TGSVMNLVSN NSIEDSDMDS DDEILTLCTS
SRKRNKPKWE LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK
EYHYKSKVRV LRIDAPEQQC
//
