ID SYME_ECO57 Reviewed; 113 AA.
AC Q8X485;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 28-JAN-2026, entry version 99.
DE RecName: Full=Endoribonuclease SymE {ECO:0000255|HAMAP-Rule:MF_01193};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01193};
GN Name=symE {ECO:0000255|HAMAP-Rule:MF_01193};
GN OrderedLocusNames=Z5945, ECs5305.1;
OS Escherichia coli O157:H7.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Involved in the degradation and recycling of damaged RNA. It
CC is itself a target for degradation by the ATP-dependent protease Lon.
CC {ECO:0000255|HAMAP-Rule:MF_01193}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01193}.
CC -!- SIMILARITY: Belongs to the SymE family. {ECO:0000255|HAMAP-
CC Rule:MF_01193}.
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DR EMBL; AE005174; AAG59528.1; -; Genomic_DNA.
DR EMBL; BA000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; D86133; D86133.
DR RefSeq; WP_000132630.1; NZ_AP018488.1.
DR AlphaFoldDB; Q8X485; -.
DR STRING; 155864.Z5945; -.
DR KEGG; ece:Z5945; -.
DR PATRIC; fig|83334.175.peg.75; -.
DR eggNOG; ENOG5031VID; Bacteria.
DR OMA; MRQHTRT; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:InterPro.
DR HAMAP; MF_01193; Endoribonucl_SymE; 1.
DR InterPro; IPR007159; SpoVT-AbrB_dom.
DR InterPro; IPR014944; Toxin_SymE-like.
DR InterPro; IPR020883; TypeI_TA_SymE.
DR NCBIfam; NF010128; PRK13605.1; 1.
DR Pfam; PF08845; SymE_toxin; 1.
DR PROSITE; PS51740; SPOVT_ABRB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome; RNA-binding.
FT CHAIN 1..113
FT /note="Endoribonuclease SymE"
FT /id="PRO_0000297818"
FT DOMAIN 29..74
FT /note="SpoVT-AbrB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ SEQUENCE 113 AA; 12294 MW; 103D9607059B3CD5 CRC64;
MTDTHSIAQP FEAEVSPANN RQLTVSYASR YPDYSRIPAI TLKGQWLEAA GFATGTVVDV
KVMEGCIVLT AQPPAAAESE LMQSLRQVCK LSARKQRQVQ EFIGVIAGKQ KVA
//
