ID U4UJL4_DENPD Unreviewed; 858 AA.
AC U4UJL4;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 18-JUN-2025, entry version 61.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=D910_10597 {ECO:0000313|EMBL:ERL93302.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL93302.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL93302.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Docking T.R., Chan S.K., Taylor G.A.,
RA Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H., Janes J.K.,
RA Zhao Y., Pandoh P., Moore R., Sperling F.A., Huber D.P., Birol I.,
RA Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
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DR EMBL; KB632352; ERL93302.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UJL4; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR CDD; cd19502; RecA-like_PAN_like; 1.
DR CDD; cd16626; RING-HC_RBR_HHARI; 1.
DR FunFam; 2.40.50.140:FF:000027; 26S protease regulatory subunit 10B; 1.
DR FunFam; 3.40.50.300:FF:000034; 26S protease regulatory subunit 10B; 1.
DR FunFam; 1.20.120.1750:FF:000002; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR050221; 26S_Proteasome_ATPase.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_2nd.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23073; 26S PROTEASOME REGULATORY SUBUNIT; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB_C; 1.
DR Pfam; PF21235; UBA_ARI1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00647; IBR; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 488..724
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 492..541
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 14..55
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 858 AA; 98980 MW; 35DA49B556542106 CRC64;
MATLADRAKV LQDYRKKLLE HKEVESRLKE MREQLKDLTK QYDKSENDLK ALQSMGQIVG
EVLKQLTEEK FIVKATNGPR YVVGCRRQLD KAKLKAGTRV ALDMTTLTIM RYLPREVDPL
VYNMSHEDPG DVTYSAIGGL SEQIRELREV IELPLLNPEL FMRVGITPPK GCLLYGPPGT
GKTLLARAVA SQLDANFLKV VSSAIVDKYI GESARLIREM FNYAKDHQPC IIFMDEIDAI
GGRRFSEGTS ADREIQRTLM ELLNQMDGFD SLGQVKMIMA TNRPDTLDPA LLRPGRLDRK
IEIPLPNEQA RLEILKIHAG PIAKHGEIDY EAIVKLSDNF NGADLRNVCT EAGLFAIRAE
RETMNEEDEI IYDDSGNETS GDDVDFAIDA DNSCREFPSY DDEYQYEVLS TDEIVQHMVD
CIKDVNIVVQ IPSTTTRILL NFFNWDKEKL MEKFFDGNQE ELFKEARVVN PFKKVTAVKP
RLFNKVLGTE ECEICFIVHP PIHMTGLECG HRFCTQCWNE YLTTKIMEEG VGQTIACPAH
NCAILVDDET VMELLKDPRV KLKFQHLITN SFVKCNRLLR WCPSPDCSYA IKVAKCIIPH
LKTGHFQVTY VETKPVTCEC GHRFCFNCGE NWHDPVKCTL LKKWQKKCDD DSETSNWLAA
NTKECPKCNA TIEKDGGCNH MTINVFSRYN CNRYDEDEAK AARDAQELSR AALQRYLFYC
NRYMNHMQSL KFEHKLYAAV KDKMEEMQQH NMSWIEVQFL KKAVDILCQC RQTLMYTYVF
AYYLKKTNQS VIFEENQKDL ERATELLSEY LERDITQENL LDIKQKVQDK YRYCDGRQIA
LLKHVHEGYE KDCWLYSE
//
