ID U7UQG4_9FIRM Unreviewed; 703 AA.
AC U7UQG4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 10-JUN-2026, entry version 46.
DE SubName: Full=Vitamin B12-dependent methionine synthase, activation domain protein {ECO:0000313|EMBL:ERT61662.1};
GN ORFNames=HMPREF1250_2274 {ECO:0000313|EMBL:ERT61662.1};
OS Megasphaera vaginalis (ex Srinivasan et al. 2021).
OC Bacteria; Bacillati; Bacillota; Negativicutes; Veillonellales;
OC Veillonellaceae; Megasphaera.
OX NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT61662.1, ECO:0000313|Proteomes:UP000017090};
RN [1] {ECO:0000313|EMBL:ERT61662.1, ECO:0000313|Proteomes:UP000017090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT61662.1,
RC ECO:0000313|Proteomes:UP000017090};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT61662.1}.
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DR EMBL; AWXA01000008; ERT61662.1; -; Genomic_DNA.
DR RefSeq; WP_023052952.1; NZ_AWXA01000008.1.
DR AlphaFoldDB; U7UQG4; -.
DR STRING; 1111454.HMPREF1250_2274; -.
DR PATRIC; fig|1111454.3.peg.613; -.
DR eggNOG; COG2871; Bacteria.
DR eggNOG; COG3894; Bacteria.
DR OrthoDB; 9810588at2; -.
DR Proteomes; UP000017090; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0008705; F:methionine synthase activity; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.40.109.40; -; 1.
DR Gene3D; 3.30.420.480; Domain of unknown function (DUF4445); 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR052911; Corrinoid_activation_enz.
DR InterPro; IPR041414; RamQ-like_middle.
DR InterPro; IPR042259; RamQ-like_middle_sf.
DR InterPro; IPR027980; RamQ_C.
DR InterPro; IPR037010; VitB12-dep_Met_synth_activ_sf.
DR PANTHER; PTHR42895:SF2; IRON-SULFUR CLUSTER PROTEIN; 1.
DR PANTHER; PTHR42895; IRON-SULFUR CLUSTER-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF14574; RACo_C_ter; 1.
DR Pfam; PF17651; Raco_middle; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF56507; Methionine synthase activation domain-like; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000017090}.
FT DOMAIN 188..282
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
SQ SEQUENCE 703 AA; 74582 MW; A8E5F64A26F62B2E CRC64;
MTMADIRALT GSRIVPDTDT VLRLLGVGDK SARYEQYQRQ VRMLIRPRAI LAFEKCSLYV
VMTLGAAISD YVARLFARHE EDEALWINAI ADSCLFAFEE QIRKTIGDLC REKGRGVAGR
REVGNGLEPE SVRRILEMTE ARRRIGVSMT ATGMVLPSKT MCFLFDLTAH TDADAGAGIN
PCRQCGNDTC TLRRSAAAGR VYTCPPGESV LTFLRRNGVS LGAACGGNGS CGKCRVRLYN
GHLDVTYDDL ATLSAEELDR GWRLACKAVP QEPVTVCVSQ GEENSFRAVG TLTEPLKKAA
AGHRFGAAVD VGTTTIAVSL VDLTARKVVD TVTAVNSQRV YGADVISRIQ AAAAGHAAAL
RRLVCRDIYG ALQRLWQRYE GTFADCGEIV VASNTTMTHL LLGLDCSGLG RWPFTPVSLG
GDVLPWRRIF PDYAGPAACR IRIVPGISTY VGADVVAGLY ACRLDSDGKN AVFLDLGTNG
EMAVAKEGML YVASAAAGPA LEGGQLSCGT GSVPGAVAAV DIIDGKAAVR TIDCAPAAGL
CGTGVIEALA ALLQAGFVDR SGKLAAPYFS GGFPIARKQD GTVLTLTQQD IRQVQLAKGA
VRAGLEALLQ HCGLTYGDVG TLYLAGGFGY FLKAEKAAAV GLLPRELAAR TVNVGNTSLA
GAVALLTERD GEERLRKIIA SAREVALAGD AAFRQLYINY MDF
//
