ID VP2_SVSAP Reviewed; 165 AA.
AC Q672H9;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 28-JAN-2026, entry version 50.
DE RecName: Full=Minor capsid protein VP2;
GN ORFNames=ORF2;
OS Sapporo virus (isolate GI/Human/Germany/pJG-Sap01)
OS (Hu/Dresden/pJG-Sap01/DE).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Caliciviridae; Sapovirus; Sapovirus sapporoense;
OC Sapporo virus.
OX NCBI_TaxID=291175;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=17121797; DOI=10.1128/jvi.01462-06;
RA Fullerton S.W., Blaschke M., Coutard B., Gebhardt J., Gorbalenya A.,
RA Canard B., Tucker P.A., Rohayem J.;
RT "Structural and functional characterization of sapovirus RNA-dependent RNA
RT polymerase.";
RL J. Virol. 81:1858-1871(2007).
CC -!- FUNCTION: Minor structural protein that forms a portal-like structure
CC at a unique three-fold axis of symmetry, following binding to the host
CC receptor. The channel formed by VP2 may allow the delivery of the viral
CC genome through the host endosomal membrane.
CC {ECO:0000250|UniProtKB:P28711}.
CC -!- SUBUNIT: Homooligomer. The portal-like structure consists in 12 copies
CC of VP2. Interacts with capsid protein VP1.
CC {ECO:0000250|UniProtKB:P28711}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P28711}. Host
CC cytoplasm {ECO:0000305}.
CC -!- DOMAIN: The N-terminus domain points away from the virion surface.
CC {ECO:0000250|UniProtKB:P28711}.
CC -!- MISCELLANEOUS: Translated by a ribosomal termination-reinitiation
CC process from the bicistronic mRNA coding for VP1 and VP2.
CC {ECO:0000250|UniProtKB:P28711}.
CC -!- SIMILARITY: Belongs to the vesivirus VP2 protein family. {ECO:0000305}.
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DR EMBL; AY694184; AAU09267.1; -; Genomic_RNA.
DR RefSeq; YP_077280.1; NC_006269.1.
DR KEGG; vg:5176813; -.
DR OrthoDB; 34562at10239; -.
DR Proteomes; UP000007049; Segment.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098021; C:viral capsid, decoration; IEA:UniProtKB-KW.
DR InterPro; IPR008437; Minor_structural_calicivir.
DR Pfam; PF05752; Calici_MSP; 1.
PE 3: Inferred from homology;
KW Capsid decoration protein; Capsid protein; Host cytoplasm;
KW Reference proteome; Virion.
FT CHAIN 1..165
FT /note="Minor capsid protein VP2"
FT /id="PRO_0000342119"
FT REGION 128..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 17814 MW; 7D6B7C5D4AB1DBC0 CRC64;
MSWLVGALQT FGSLADVAGT VSNIVYQQRQ AAQLEKQNEL METWMNKQEA LQKSQMELTR
DLSINGPAAR VQSALDAGFD EVSARRIAGS GERVIWGNLD RPIMHAGTMD SIRQTRHLDS
LSHSLATFKN GTPFGKPAPP TAKSGRPQAT TAQITIGHNP GSTSV
//
