ID W0DJM3_9GAMM Unreviewed; 638 AA.
AC W0DJM3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 28-JAN-2026, entry version 52.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=THITH_11725 {ECO:0000313|EMBL:AHE98804.1};
OS Thioalkalivibrio paradoxus ARh 1.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Chromatiales; Ectothiorhodospiraceae; Thioalkalivibrio.
OX NCBI_TaxID=713585 {ECO:0000313|EMBL:AHE98804.1, ECO:0000313|Proteomes:UP000005289};
RN [1] {ECO:0000313|EMBL:AHE98804.1, ECO:0000313|Proteomes:UP000005289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARh 1 {ECO:0000313|EMBL:AHE98804.1,
RC ECO:0000313|Proteomes:UP000005289};
RG DOE Joint Genome Institute;
RA Muyzer G., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP007029; AHE98804.1; -; Genomic_DNA.
DR RefSeq; WP_006747965.1; NZ_CP007029.1.
DR AlphaFoldDB; W0DJM3; -.
DR STRING; 713585.THITH_11725; -.
DR KEGG; tti:THITH_11725; -.
DR HOGENOM; CLU_023030_2_0_6; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000005289; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF9; GTP-BINDING PROTEIN 1; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:AHE98804.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000005289}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 638 AA; 69520 MW; F39171105CC36753 CRC64;
MIVGTAGHID HGKTALVKAL TGIDADRLAE EQTRGITLDL GYAYQRLASG EVLGFVDVPG
HEKLVHNMLA GATGIDFVLL VIAADDGPMP QTREHLEILE LLGLNRGAVA LTKIDLADQA
RLAALQGEVR ALLAPTGLAQ APVFPVSAMT GAGVDALREH LHAAAAAIPP RPGTGRFRLA
IDRRFTLRGA GTVVTGTAHA GQVRVGDELV LSPSGQPVRV RGIHAQNRAA ETGIAGQRCA
LNLTGPGLDK DAIARGDWVI DPELHRPSAR IDARVHVPGD APKPLRHWSP VHLHLGSARL
MARVAVLEGD AIEPGTQGFA QLVLENQTHA LRGDRFVLRD PSARHNLAGG TVLDDRPPAR
GRRRPARIAL LRALAVDDPT EALAAMLPHA ERGLNLRDFT RMWNLDDSWA SAQAISAGLR
AVETAAGPVA FAPEHWDALR QRTLAMLAEE HQRHPERLGP DRERLRRRAA PRVERPVFGA
LLDEMTAAGD VVLNAPWIHL PGHQVTLAPT DERIWLQDIR PMLGARPFNP PRVRDIARAL
RLEEDRVRRL MRQLAGMGEV YKVAHDHYYT RAAVADLAAI ARDLSEHEGK ALAAPFRDRI
ATGRKVAIQI LEFFDRIGYS RRVGDEHRIF PDSLLKLR
//
