ID W4QUF1_HALA3 Unreviewed; 638 AA.
AC W4QUF1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 28-JAN-2026, entry version 53.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=JCM9157_2837 {ECO:0000313|EMBL:GAE35716.1};
OS Halalkalibacter akibai (strain ATCC 43226 / DSM 21942 / CIP 109018 / JCM
OS 9157 / 1139) (Bacillus akibai).
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Halalkalibacter.
OX NCBI_TaxID=1236973 {ECO:0000313|EMBL:GAE35716.1, ECO:0000313|Proteomes:UP000018896};
RN [1] {ECO:0000313|EMBL:GAE35716.1, ECO:0000313|Proteomes:UP000018896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9157 {ECO:0000313|EMBL:GAE35716.1,
RC ECO:0000313|Proteomes:UP000018896};
RA Yuki M., Oshima K., Suda W., Oshida Y., Kitamura K., Iida T., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequences of Three Alkaliphilic Bacillus Strains, Bacillus
RT wakoensis JCM 9140T, Bacillus akibai JCM 9157T, and Bacillus
RT hemicellulosilyticus JCM 9152T.";
RL Genome Announc. 2:e01258-13(2014).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE35716.1}.
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DR EMBL; BAUV01000022; GAE35716.1; -; Genomic_DNA.
DR RefSeq; WP_035665233.1; NZ_BAUV01000022.1.
DR AlphaFoldDB; W4QUF1; -.
DR STRING; 1236973.JCM9157_2837; -.
DR eggNOG; COG3276; Bacteria.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000018896; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:GAE35716.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000018896}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 638 AA; 72355 MW; 0FD24EF3B354CF46 CRC64;
MNHYTVGMAG HIDHGKTTLT KALTNVDTDR LKEEKERSIS IELGYAPLTL NDDMEVSLID
VPGHERFIRQ MIAGVAGIDL VMLVVAGDEG VMPQTKEHID ILRLLGIKNG IIVVTKVDKI
DEEMRQLVEL DIRESVEETF FNDSPLFFVD GVSGAGVEQL KAGIELALQG QESRDASGSF
RLPIDQVFTV HGQGTVVRGT VYEGIVQEGD VLEILPQKIP VRARQLQVHH QRRESGRAGQ
RVAVNVGGVS KEELTRGDVL VASGHYETTD TIDVSLSTVA ELKYALKQRG AIKLHIGTAE
VYGKIVFFDR NELSESNEEV VCQLRLDEPV VTRRGDRFIL RRPTPTETIG GGVVIDAHGL
KYRFGEQTIH QLKSKLEATP KERMLQLLMD KKLITVEAVS KELNLTETTI EEIVNDSDEL
IELVQGEISS RSVITSMTDL LRSELERYHT DHPMREGIKK AEIIQSYEKT FPKKFINAIL
EDQTKIGMIK VMGPFVALFE HEPHPPKQWE KRVQQIVEQI RKEGLLVTPV QEHLKAQQLP
EKLHEEVIFY LHQQQILFQL DEKLSIHAEA FIDAVSRLYS GTSETFTLQQ AKEITDLSRK
YLVPFMEKLD KLGLTLRQEQ ERKWRVTEVE NWLQRNNH
//
