ID W5KPJ2_ASTMX Unreviewed; 209 AA.
AC W5KPJ2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 28-JAN-2026, entry version 70.
DE SubName: Full=Eyes shut homolog {ECO:0000313|Ensembl:ENSAMXP00000009504.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009504.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009504.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSAMXP00000009504.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; W5KPJ2; -.
DR STRING; 7994.ENSAMXP00000009504; -.
DR Ensembl; ENSAMXT00000009504.2; ENSAMXP00000009504.2; ENSAMXG00000009249.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160615; -.
DR HOGENOM; CLU_004826_12_1_1; -.
DR InParanoid; W5KPJ2; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009249; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProtKB-ARBA.
DR GO; GO:0023052; P:signaling; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00054; EGF_CA; 1.
DR FunFam; 2.10.25.10:FF:000143; Protein crumbs 1; 1.
DR FunFam; 2.10.25.10:FF:000006; Versican core protein-like isoform 1; 1.
DR FunFam; 2.10.25.10:FF:000391; Weary, isoform C; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; UNINFLATABLE, ISOFORM C; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF23106; EGF_Teneurin; 1.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..13
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 15..51
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 53..88
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 90..125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 127..165
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 167..202
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 3..12
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 41..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 136..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 155..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 209 AA; 22866 MW; C5B1E7C5C18F5C64 CRC64;
CRCDRGYTGV HCELRVDHCL GHQCSEHGVC LNQRHNYTCR CVPGYEGTLC EIETDECSSS
PCASGATCVD SVASYWCLCA SGFERTCSEN TNDCWSMPCL NGGSCVDLIN DYICICPSFD
GDDCSRVVNR CPSDQCDARG TSTCEELEGT FRCICRHGFT GKQCETPISH CVKDLCHAGS
TCVDLPRGFE CQCLPLTGRF CEIDIDDCA
//
