ID W5N9F9_LEPOC Unreviewed; 686 AA.
AC W5N9F9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 28-JAN-2026, entry version 54.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017268.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017268.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLOCP00000017268.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AHAT01000595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N9F9; -.
DR FunCoup; W5N9F9; 588.
DR Ensembl; ENSLOCT00000017299.1; ENSLOCP00000017268.1; ENSLOCG00000014010.1.
DR GeneID; 102688180; -.
DR KEGG; loc:102688180; -.
DR CTD; 79755; -.
DR eggNOG; ENOG502QU7X; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR InParanoid; W5N9F9; -.
DR OMA; TERINDK; -.
DR OrthoDB; 8933073at2759; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000014010; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 60..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 74741 MW; 7616FDFDF9CA998B CRC64;
MSSTKERKPK KPHYIPRPPG KPFKYHCFQC PFTCNEKSHL FNHMKYNLCR NSITLVSEQD
RSGKPAKPAA ADPSLRVSAE PTDKHSIPAA EESVSAKDDA LPEQRITEEP EEEAQSQRRR
GSQSPTGSLQ RDLKVRLPES RMDKQPEPIP RPSAFVPIAA HRPVDRTDNR DMPPFHKPEG
PAPALSFKPT YYHPSAAWRA TPGFVPPEFS HKSSPGKVVG PTNYPSAVMP EYTPYIFAEH
PMTAIYQPYL IPGNPHEHEG TPFPSYFIDP QRSMFPHVFP APTIPLPSPL PPSALENPYR
LYQSVHQAPP IHYGMYRPPH THEPSFQDFP TKSLLPVEGY GRDVGAGECN RYPGSRSPAT
TDTHSKHAKD FPRPAGSSAT GSQEQGAESE MKMSPRAGCA ASGSPDRPSP TGFTQNDPVS
DSHHPAFESG RPHSHLPGDS LALKRIADPP SPPPAASQKD TRRPAESSAE SRGQASNTFD
PCSSQGTSET EEEDEVPLNL SKKHHVVEGE HVITLPVSRG SSPGTGDKHD MQDMPLNLSL
RACASQSKPP SPASCSLEAP PHSPTPVQME RGSGGQYAPS SPQLESIDEQ KQTAAFALCQ
LASSSTRTVN PEPAPSLPQG NPGNKVAQCG NSLPPSGTPD AQTVVHRSSD KGQKRPSCEE
PCTFPQSTKK SKTETNRTLR KRPRCS
//
