ID W5NMF4_LEPOC Unreviewed; 384 AA.
AC W5NMF4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 28-JAN-2026, entry version 67.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSLOCP00000021813.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000021813.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000021813.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLOCP00000021813.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AHAT01019073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NMF4; -.
DR STRING; 7918.ENSLOCP00000021813; -.
DR Ensembl; ENSLOCT00000021850.1; ENSLOCP00000021813.1; ENSLOCG00000017708.1.
DR GeneID; 102683522; -.
DR KEGG; loc:102683522; -.
DR CTD; 122809; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000166202; -.
DR HOGENOM; CLU_035609_0_0_1; -.
DR InParanoid; W5NMF4; -.
DR OMA; KCDGACA; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000017708; Expressed in heart and 7 other cell types or tissues.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 1.10.750.20:FF:000001; Ankyrin repeat and SOCS box containing 1; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 238..333
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 328..377
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 43082 MW; CFC8650A7E973604 CRC64;
MSEKKAWSAD ARPKCNRSRS ADSYAWSSKK RSRGARNEPA PGAAEGEEPG HVGRSASCPR
RHRETRCSCS PAGDGDCERP SCRKALSRRS LRQKFQDAVG QCFPIRSHHH HHHHHPAGTS
RVLSVQLWSK RKIHVSELMQ DKCPFSPKSE LAHCWHLIKK QGSLKGVEAE QKDGLGSASP
PALISWEEIR LPRSQGGGEG SLEEWDLSLR PEAGPDSPPP GSMHCLVPDL LQINNSPCYW
GVLDRYEAEE LLEGQPEGTF LLRDSAQEEF LFSVSFRRYS RSLHARIEQS GKRFSFDGRD
PCVYRDPSVT GLLRHYSDPA TCLFFEPLLS RPLPRNFPFP LQHLCRAVIC SCTTYQGIDG
LPLPTSLQDY LRQYHYKCSG ASAV
//
