ID   W9WTF1_9EURO            Unreviewed;       573 AA.
AC   W9WTF1;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   28-JAN-2026, entry version 34.
DE   SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:EXJ71223.1};
GN   ORFNames=A1O5_05029 {ECO:0000313|EMBL:EXJ71223.1};
OS   Cladophialophora psammophila CBS 110553.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ71223.1, ECO:0000313|Proteomes:UP000019471};
RN   [1] {ECO:0000313|EMBL:EXJ71223.1, ECO:0000313|Proteomes:UP000019471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ71223.1,
RC   ECO:0000313|Proteomes:UP000019471};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXJ71223.1}.
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DR   EMBL; AMGX01000007; EXJ71223.1; -; Genomic_DNA.
DR   RefSeq; XP_007743822.1; XM_007745632.1.
DR   AlphaFoldDB; W9WTF1; -.
DR   STRING; 1182543.W9WTF1; -.
DR   GeneID; 19189749; -.
DR   eggNOG; KOG1116; Eukaryota.
DR   HOGENOM; CLU_013399_0_1_1; -.
DR   OrthoDB; 3853857at2759; -.
DR   Proteomes; UP000019471; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR   GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-ARBA.
DR   GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 2.60.200.40; -; 1.
DR   Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR055916; DUF7493.
DR   InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF24321; DUF7493; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EXJ71223.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019471};
KW   Transferase {ECO:0000313|EMBL:EXJ71223.1}.
FT   DOMAIN          143..282
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   REGION          486..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  62428 MW;  FE3B6D35E2E07BD5 CRC64;
     MASVDISSDA PSDPFSDQAA IQDERETVAE STLGVGRNAT LTLGTDAVIV LDEGLRISEG
     FDCFGIFSQR TTNTRSIPYF NVLWAEIVKG ELTVHYAKPT SKAANSPVRV AYINYTLESS
     TAILDKAERW VERLLRRAYG QAQRKKRIKV LINPFGGKGK AVKQYTKEIE PIFAAARCEV
     DAERTTHHGH AVEIAEKLDI NAFDAIANVS GDGLPHECIN GLAKKPNAAE ALRKVAVVQL
     PCGSGNGMAW NLTGTGECST AALCVVKGVR TPLDLVSITQ GNTRTLSFLS QSLGIVAESD
     LGTENLRWMG DARFYFGFLV RLLGKTLYPC DIAVKTEIED KQEIKRHYAQ HMARRATQTP
     ISHSDLDGPL DMSKNLGLPP LRYGTVNDPL PTDAGWTPLT FYPNLGNLYC GNMTMMAADA
     PFFPASLPSD GLLDFVTIDG DIPRRKALDL LLSVPKGAFF DKECVRVRKV SALRVIPRYG
     SIADSAAEND HRRNKQGQVV DQISSGKNAN RDAGHFSVDG EKMPFEPFQI EVHRGLGTVL
     SRRVGVYEAI GPKGWEDIDV TAPTATDQGS GSR
//