ID ZN750_XENTR Reviewed; 671 AA.
AC Q28BT7; Q6DIF8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 28-JAN-2026, entry version 85.
DE RecName: Full=Zinc finger protein 750;
GN Name=znf750; ORFNames=TNeu069m12.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in epidermis differentiation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CR942644; CAJ82741.1; -; mRNA.
DR EMBL; BC075584; AAH75584.1; -; mRNA.
DR RefSeq; NP_001004995.1; NM_001004995.1.
DR AlphaFoldDB; Q28BT7; -.
DR SMR; Q28BT7; -.
DR FunCoup; Q28BT7; 614.
DR STRING; 8364.ENSXETP00000026768; -.
DR PaxDb; 8364-ENSXETP00000044280; -.
DR DNASU; 448470; -.
DR Ensembl; ENSXETT00000044280; ENSXETP00000044280; ENSXETG00000020479.
DR GeneID; 448470; -.
DR KEGG; xtr:448470; -.
DR AGR; Xenbase:XB-GENE-5775684; -.
DR CTD; 79755; -.
DR Xenbase; XB-GENE-5775684; znf750.
DR eggNOG; ENOG502QU7X; Eukaryota.
DR HOGENOM; CLU_023455_0_0_1; -.
DR InParanoid; Q28BT7; -.
DR OMA; PSAYDHY; -.
DR OrthoDB; 8933073at2759; -.
DR PhylomeDB; Q28BT7; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Bgee; ENSXETG00000020479; Expressed in gastrula and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 2: Evidence at transcript level;
KW Activator; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..671
FT /note="Zinc finger protein 750"
FT /id="PRO_0000247074"
FT ZN_FING 25..51
FT /note="CCHC-type"
FT /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT REGION 66..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT BINDING 43
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT BINDING 49
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q32MQ0"
FT CONFLICT 513
FT /note="I -> M (in Ref. 1; CAJ82741)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 671 AA; 74240 MW; C5684C51BB9D0BAF CRC64;
MSLVKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITVVTDQD
RIVKNPKVNS TDQKQPSNEP FAKSPVPAIN GLTGLESKTQ HSVAREEAKE NFDLKNEAKP
HVEKTTVTKE VTLPPTAIIG QINKPPSLDG VMRPSAFIPV GEHRLKGTEN IKIPELSSVS
TEPAKGVHSI KSAFHSLPTP WKSGLVSPDF SHKSSIPRYI RPMISEYPPQ FYSETGLPAV
FSPYLFPQAE CENPMLSVYS APEQRPFLPH PLQASGLPLP KPINAPFEHY RLLQQFQQNP
QLHYGFYRPT EHPYFSYGLK VPPVPSLSKE HTSQSVDSPT FIYPSSHPSR LYPLEGFQKL
AEIQKETSPV PAKNLDSKSD SESVKMSPRA GSAATGSPGR PSPTNFTQNS QGHEGIFDLS
TKSTSDKAGK DFTSGKAVRK STDCQTTISR EHSPCFRNDE IQSHSDCYSD DAAPHDSVAP
LNLSKRPEVE DRAVFDTMHN SDSNDESVGF MEIQDLPLNL SVKDSGNNQK ALCADERLLL
PRQVTSSPNY HFIHTVDKRV PATTGVHSLG IIENCDEQKQ SAAVALCQLA TSSPGVPARG
TEDEFSEKET VAPEQVHPRA PAAQETEADI GARGQKRTNS KEPGKSQSSN KKHKSVDSGR
MFTLRKRPRV S
//
