KEGG   Vulpes vulpes (red fox): 112919942
Entry
112919942         CDS       T05911                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp00562  Inositol phosphate metabolism
vvp01100  Metabolic pathways
vvp04015  Rap1 signaling pathway
vvp04020  Calcium signaling pathway
vvp04022  cGMP-PKG signaling pathway
vvp04062  Chemokine signaling pathway
vvp04070  Phosphatidylinositol signaling system
vvp04071  Sphingolipid signaling pathway
vvp04072  Phospholipase D signaling pathway
vvp04081  Hormone signaling
vvp04082  Neuroactive ligand signaling
vvp04261  Adrenergic signaling in cardiomyocytes
vvp04270  Vascular smooth muscle contraction
vvp04310  Wnt signaling pathway
vvp04371  Apelin signaling pathway
vvp04540  Gap junction
vvp04611  Platelet activation
vvp04613  Neutrophil extracellular trap formation
vvp04621  NOD-like receptor signaling pathway
vvp04713  Circadian entrainment
vvp04720  Long-term potentiation
vvp04723  Retrograde endocannabinoid signaling
vvp04724  Glutamatergic synapse
vvp04725  Cholinergic synapse
vvp04726  Serotonergic synapse
vvp04728  Dopaminergic synapse
vvp04730  Long-term depression
vvp04742  Taste transduction
vvp04750  Inflammatory mediator regulation of TRP channels
vvp04911  Insulin secretion
vvp04912  GnRH signaling pathway
vvp04915  Estrogen signaling pathway
vvp04916  Melanogenesis
vvp04918  Thyroid hormone synthesis
vvp04919  Thyroid hormone signaling pathway
vvp04921  Oxytocin signaling pathway
vvp04922  Glucagon signaling pathway
vvp04924  Renin secretion
vvp04925  Aldosterone synthesis and secretion
vvp04926  Relaxin signaling pathway
vvp04927  Cortisol synthesis and secretion
vvp04928  Parathyroid hormone synthesis, secretion and action
vvp04929  GnRH secretion
vvp04933  AGE-RAGE signaling pathway in diabetic complications
vvp04934  Cushing syndrome
vvp04935  Growth hormone synthesis, secretion and action
vvp04961  Endocrine and other factor-regulated calcium reabsorption
vvp04970  Salivary secretion
vvp04971  Gastric acid secretion
vvp04972  Pancreatic secretion
vvp04973  Carbohydrate digestion and absorption
vvp05010  Alzheimer disease
vvp05016  Huntington disease
vvp05017  Spinocerebellar ataxia
vvp05022  Pathways of neurodegeneration - multiple diseases
vvp05142  Chagas disease
vvp05143  African trypanosomiasis
vvp05146  Amoebiasis
vvp05163  Human cytomegalovirus infection
vvp05200  Pathways in cancer
vvp05415  Diabetic cardiomyopathy
vvp05417  Lipid and atherosclerosis
Module
vvp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112919942 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112919942 (PLCB2)
   04310 Wnt signaling pathway
    112919942 (PLCB2)
   04371 Apelin signaling pathway
    112919942 (PLCB2)
   04020 Calcium signaling pathway
    112919942 (PLCB2)
   04070 Phosphatidylinositol signaling system
    112919942 (PLCB2)
   04072 Phospholipase D signaling pathway
    112919942 (PLCB2)
   04071 Sphingolipid signaling pathway
    112919942 (PLCB2)
   04022 cGMP-PKG signaling pathway
    112919942 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112919942 (PLCB2)
   04081 Hormone signaling
    112919942 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112919942 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112919942 (PLCB2)
   04613 Neutrophil extracellular trap formation
    112919942 (PLCB2)
   04621 NOD-like receptor signaling pathway
    112919942 (PLCB2)
   04062 Chemokine signaling pathway
    112919942 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    112919942 (PLCB2)
   04922 Glucagon signaling pathway
    112919942 (PLCB2)
   04929 GnRH secretion
    112919942 (PLCB2)
   04912 GnRH signaling pathway
    112919942 (PLCB2)
   04915 Estrogen signaling pathway
    112919942 (PLCB2)
   04921 Oxytocin signaling pathway
    112919942 (PLCB2)
   04926 Relaxin signaling pathway
    112919942 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    112919942 (PLCB2)
   04918 Thyroid hormone synthesis
    112919942 (PLCB2)
   04919 Thyroid hormone signaling pathway
    112919942 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    112919942 (PLCB2)
   04916 Melanogenesis
    112919942 (PLCB2)
   04924 Renin secretion
    112919942 (PLCB2)
   04925 Aldosterone synthesis and secretion
    112919942 (PLCB2)
   04927 Cortisol synthesis and secretion
    112919942 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112919942 (PLCB2)
   04270 Vascular smooth muscle contraction
    112919942 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    112919942 (PLCB2)
   04971 Gastric acid secretion
    112919942 (PLCB2)
   04972 Pancreatic secretion
    112919942 (PLCB2)
   04973 Carbohydrate digestion and absorption
    112919942 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112919942 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    112919942 (PLCB2)
   04725 Cholinergic synapse
    112919942 (PLCB2)
   04728 Dopaminergic synapse
    112919942 (PLCB2)
   04726 Serotonergic synapse
    112919942 (PLCB2)
   04720 Long-term potentiation
    112919942 (PLCB2)
   04730 Long-term depression
    112919942 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    112919942 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    112919942 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    112919942 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112919942 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112919942 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112919942 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112919942 (PLCB2)
   05142 Chagas disease
    112919942 (PLCB2)
   05143 African trypanosomiasis
    112919942 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112919942 (PLCB2)
   05016 Huntington disease
    112919942 (PLCB2)
   05017 Spinocerebellar ataxia
    112919942 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    112919942 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112919942 (PLCB2)
   05415 Diabetic cardiomyopathy
    112919942 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112919942 (PLCB2)
   04934 Cushing syndrome
    112919942 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vvp04131]
    112919942 (PLCB2)
Enzymes [BR:vvp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112919942 (PLCB2)
Membrane trafficking [BR:vvp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112919942 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112919942 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh C2 EF-hand_like Gp58 FlgT_N Seadorna_VP6 IATP
Other DBs
NCBI-GeneID: 112919942
NCBI-ProteinID: XP_025854243
Position
Unknown
AA seq 1182 aa
MSLLSPVLLPPKVEAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKETEFLD
ITSIRDTRFGKFAKIPKSQKLREVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKNWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLSQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPAAPSKESGGE
AEGNCPPNASVGEGTVWPGEEGEELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFELSAQKNRSYVISSFTELKAYDLLSKASVKFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
RLSPSANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMGAL
PEKPFPPGSPVAGQVNGPLAPVSNGSAAARARAREEAAKEAAEPQTASPEELQELKGVVK
LQRRHEKELRDLERRGARRREELLQRGAAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAG
AAPQEDREGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQIAKMMELARE
KQAAELKTLKETLETDTKEMKKKLEAKRLERIQAMVKVTSDKMAQERLKREINNSHIQEV
VQVIKQMTESLEKHQEKLEEKQAACLEQIREMEKQFQQEALAEYEARMKGLEAEVKESVR
ACLRSCFPSEAKDMPERPYEAFRELCEQDPLAAKAGAQESRL
NT seq 3549 nt   +upstreamnt  +downstreamnt
atgtctctgctcagccctgtcctgctgccccccaaggtggaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacgatagcttctccggttatcctccgtgtg
gatcccaagggctactacttatattggacatatcagagtaaggagacggagtttctagat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgagaggtcttcaacatggactttcctgacaacaacttcctgctaaagacactcacc
gtggtgtctggccctgacatggtggacctcaccttccacaactttgtctcctacaaggag
aatgtgggcaagaactgggctgaagacgtgctggctctggccaagcacccactgacggcc
aatgcttcccgtagcaccttcttggacaaaatcctggtgaaactcaagatgcagctcaac
cccgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagctgccctcagtgcctgccacctcccaaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatctgtctacaagagtttcctcatgaacctctgtcctcggccagaa
atagacgagatcttcacttcttaccatgccaaggccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaaccagaaacagagggacccccgtctcaactccttgctgtttcca
cctgcgcggcctgaccaggtgcggggcctcatcgacaagtatgaacccagtggcatcaac
gtgcagaggggccagctatcacctgagggcatggtgtggtttctgtgcggcccagagaac
agcgtcctgtcccaggacaagctgctactccaccacgacatgacgcagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctctggcctctcc
tcggcggagatgtaccgccaggtgctgctggctggctgccgctgtgtggagctggactgc
tggaagggcaagccccctgacgaggagcccatcatcacccatggcttcaccatgaccaca
gacatctatttcaaggaagccattgaagccattgcagaaagtgcctttaagacctccccc
tatcctgttatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtactgccggatgatgtttggggatatgctgctcacagagcccttggaaaagttc
ccactgaaaccaggcatccctctgcctagccctgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctggcccagcagcccccagcaaggaatccggtggggaa
gctgagggaaactgcccacctaatgcctctgtgggtgagggcacagtgtggcctggtgag
gagggggaagagctggaggaggaagaggtggaggaagaggaggaggaggagtcgggaaac
ctggacgaggaagagatcaagaagatgcagtcggatgagggcacagcgggcctggaggtg
acagcctacgaggagatgtccagcctggtgaattacatccaacccaccaaattcatctcc
ttcgagctctctgcccagaagaaccgaagttatgtcatctcgtccttcacagagctcaag
gcttatgacctgctctccaaggcctcagtgaagtttgtggattacaacaagcgccagatg
agccgcatttaccctaagggcacccgcatggactcttccaactacatgccccagatgttc
tggaatgctggttgccagatggttgccctcaacttccagactatggacctgcccatgcag
cagaacatggcgctgtttgagttcaatgggcagagtggttacctcctcaagcatgagttc
atgcgccgcccagacaagcagttcaaccccttctcggtggaccgcattgacgtggtggta
gccaccaccctgtccattacggtgatctctgggcagttcctgtctgaacgcagtgtgcgc
acctatgtggaagtggaactctttggccttcctggggaccccaagaggcgctatcgcacc
aggctgtcacccagtgccaactccatcaatcctgtctggaaggaagagccttttgtcttt
gagaagatcttgatgcctgagctggcctctctcagggtggctgtaatggaggaaggcaac
aaatttcttggacaccgcatcatccccattaatgccctgaattctggctaccaccatctg
tgcctgcacagcgagagcaacatgccccttaccatgcctgcgctttttgtcttcttggag
atgaaggactatgtacctgacacctgggcagatctcaccgtggctcttgccaatcccatc
aagttcttcagtgcccacgataagaagtctgtgaagctcaaggaagccatgggagctctg
cctgagaaacccttcccccctgggagtccagttgccggccaggtcaatgggccattggcc
ccagtgagcaacggatctgcagcagcccgggccagggccagggaggaggccgccaaagaa
gctgcggagccgcagaccgccagcccggaggagctgcaggagctgaagggcgtcgtgaag
ctgcagcggcggcacgagaaggagctccgggacctggagcggcgcggcgcgcggcgccgg
gaggagctgctgcagaggggcgcggcgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngccggg
gccgcgccccaggaggaccgcgagggccccgagggcgcggacgcgcgggcgcgcgagctg
aaggaccggctggagctggagttgctgcagcagggcgaggagcagtacgagtgcatcctg
aagcgcaaggagcagcacgtggccgagcaaatcgccaagatgatggagctggccagagag
aagcaggctgcagagctgaagaccctcaaggagaccttggagactgacactaaagagatg
aagaaaaagctggaagccaagaggctggagcggattcaggccatggtcaaagtcacctca
gacaagatggctcaggaaaggctgaagagagagattaacaactcccacatccaggaagtg
gtgcaagtcattaagcagatgacagagagcctggagaagcaccaggagaagctggaggag
aagcaggcagcctgcttggaacagatccgggagatggaaaagcagttccagcaggaggct
ctggcagagtacgaggccaggatgaagggcttggaggccgaggtgaaggagtccgtgagg
gcttgccttaggagctgcttcccctctgaggccaaggacatgcctgagaggccctatgag
gccttccgggagctgtgtgagcaggacccactcgcagcaaaggcaggtgcccaggagagc
cgcctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (11)   
   Pfam (11)   
All databases (24)   

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