KEGG   Zalophus californianus (California sea lion): 113937245
Entry
113937245         CDS       T07874                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca00562  Inositol phosphate metabolism
zca01100  Metabolic pathways
zca04015  Rap1 signaling pathway
zca04020  Calcium signaling pathway
zca04022  cGMP-PKG signaling pathway
zca04062  Chemokine signaling pathway
zca04070  Phosphatidylinositol signaling system
zca04071  Sphingolipid signaling pathway
zca04072  Phospholipase D signaling pathway
zca04081  Hormone signaling
zca04082  Neuroactive ligand signaling
zca04261  Adrenergic signaling in cardiomyocytes
zca04270  Vascular smooth muscle contraction
zca04310  Wnt signaling pathway
zca04371  Apelin signaling pathway
zca04540  Gap junction
zca04611  Platelet activation
zca04613  Neutrophil extracellular trap formation
zca04621  NOD-like receptor signaling pathway
zca04713  Circadian entrainment
zca04720  Long-term potentiation
zca04723  Retrograde endocannabinoid signaling
zca04724  Glutamatergic synapse
zca04725  Cholinergic synapse
zca04726  Serotonergic synapse
zca04728  Dopaminergic synapse
zca04730  Long-term depression
zca04742  Taste transduction
zca04750  Inflammatory mediator regulation of TRP channels
zca04911  Insulin secretion
zca04912  GnRH signaling pathway
zca04915  Estrogen signaling pathway
zca04916  Melanogenesis
zca04918  Thyroid hormone synthesis
zca04919  Thyroid hormone signaling pathway
zca04921  Oxytocin signaling pathway
zca04922  Glucagon signaling pathway
zca04924  Renin secretion
zca04925  Aldosterone synthesis and secretion
zca04926  Relaxin signaling pathway
zca04927  Cortisol synthesis and secretion
zca04928  Parathyroid hormone synthesis, secretion and action
zca04929  GnRH secretion
zca04933  AGE-RAGE signaling pathway in diabetic complications
zca04934  Cushing syndrome
zca04935  Growth hormone synthesis, secretion and action
zca04961  Endocrine and other factor-regulated calcium reabsorption
zca04970  Salivary secretion
zca04971  Gastric acid secretion
zca04972  Pancreatic secretion
zca04973  Carbohydrate digestion and absorption
zca05010  Alzheimer disease
zca05016  Huntington disease
zca05017  Spinocerebellar ataxia
zca05022  Pathways of neurodegeneration - multiple diseases
zca05142  Chagas disease
zca05143  African trypanosomiasis
zca05146  Amoebiasis
zca05163  Human cytomegalovirus infection
zca05200  Pathways in cancer
zca05415  Diabetic cardiomyopathy
zca05417  Lipid and atherosclerosis
Module
zca_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:zca00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    113937245 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    113937245 (PLCB1)
   04310 Wnt signaling pathway
    113937245 (PLCB1)
   04371 Apelin signaling pathway
    113937245 (PLCB1)
   04020 Calcium signaling pathway
    113937245 (PLCB1)
   04070 Phosphatidylinositol signaling system
    113937245 (PLCB1)
   04072 Phospholipase D signaling pathway
    113937245 (PLCB1)
   04071 Sphingolipid signaling pathway
    113937245 (PLCB1)
   04022 cGMP-PKG signaling pathway
    113937245 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    113937245 (PLCB1)
   04081 Hormone signaling
    113937245 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    113937245 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113937245 (PLCB1)
   04613 Neutrophil extracellular trap formation
    113937245 (PLCB1)
   04621 NOD-like receptor signaling pathway
    113937245 (PLCB1)
   04062 Chemokine signaling pathway
    113937245 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    113937245 (PLCB1)
   04922 Glucagon signaling pathway
    113937245 (PLCB1)
   04929 GnRH secretion
    113937245 (PLCB1)
   04912 GnRH signaling pathway
    113937245 (PLCB1)
   04915 Estrogen signaling pathway
    113937245 (PLCB1)
   04921 Oxytocin signaling pathway
    113937245 (PLCB1)
   04926 Relaxin signaling pathway
    113937245 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    113937245 (PLCB1)
   04918 Thyroid hormone synthesis
    113937245 (PLCB1)
   04919 Thyroid hormone signaling pathway
    113937245 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    113937245 (PLCB1)
   04916 Melanogenesis
    113937245 (PLCB1)
   04924 Renin secretion
    113937245 (PLCB1)
   04925 Aldosterone synthesis and secretion
    113937245 (PLCB1)
   04927 Cortisol synthesis and secretion
    113937245 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    113937245 (PLCB1)
   04270 Vascular smooth muscle contraction
    113937245 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    113937245 (PLCB1)
   04971 Gastric acid secretion
    113937245 (PLCB1)
   04972 Pancreatic secretion
    113937245 (PLCB1)
   04973 Carbohydrate digestion and absorption
    113937245 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    113937245 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    113937245 (PLCB1)
   04725 Cholinergic synapse
    113937245 (PLCB1)
   04728 Dopaminergic synapse
    113937245 (PLCB1)
   04726 Serotonergic synapse
    113937245 (PLCB1)
   04720 Long-term potentiation
    113937245 (PLCB1)
   04730 Long-term depression
    113937245 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    113937245 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    113937245 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    113937245 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    113937245 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113937245 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    113937245 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    113937245 (PLCB1)
   05142 Chagas disease
    113937245 (PLCB1)
   05143 African trypanosomiasis
    113937245 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113937245 (PLCB1)
   05016 Huntington disease
    113937245 (PLCB1)
   05017 Spinocerebellar ataxia
    113937245 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    113937245 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113937245 (PLCB1)
   05415 Diabetic cardiomyopathy
    113937245 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    113937245 (PLCB1)
   04934 Cushing syndrome
    113937245 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:zca04131]
    113937245 (PLCB1)
Enzymes [BR:zca01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     113937245 (PLCB1)
Membrane trafficking [BR:zca04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    113937245 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    113937245 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 113937245
NCBI-ProteinID: XP_027477024
UniProt: A0A6J2F781
Position
8:complement(105603523..106318069)
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMHKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFESSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
ETDPGETPSEVPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYF
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHKPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcatgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccgctattgtgactcca
attattttgaggactgaccctcagggatttttcttttactggaccgatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcat
cgcatgataacggtggtatatgggcctgacttggttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
accgtcgatcagatgatggactttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaaacaagaacaagtccaagtactgattgagaagtatgaaccc
aacaatagccttgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcgcctgagaaactggatttaaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgtcgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttc
accatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagacgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccccatggacttaatgcac
aaaattttggtgaaaaataagaagaaatcgcacaagtcatcggaaggaagtggcaaaaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagcgtgttcgagtcctca
tctccaggagctggggaagctgataccgagagtgatgacgacgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgcggggagcgaggccatggccaccgaagagatg
tctaacctggtgaactatattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
agaaacaaaagttttgaaatgtcttccttcgtggaaaccaaaggcctcgagcaactgacg
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcagaatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccgttcaccgaaggcatcgtggatgggatagtagccaatactttatctgtc
aagattatttcaggtcagtttctttctgataagaaagtcgggacttacgtggaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaggga
aatgctgtaaatcctgtctgggaagaagagcccattgtcttcaaaaaggtggttcttcct
tctctggcctgtctgaggatagcagcttatgaagaaggaggtaaattcatcggtcaccgg
atcttgccagtacaggcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gaacaaagagctaaacaattggctgcattgacactggaagatgaagaagaagtaaagaaa
gagactgatcctggggaaacaccgtcagaagttccaagtgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccctggcacccaaaccaccgtcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accactgacctaatcaaagaacacactacaaagtataatgagattcagaatgactacttt
agaaggagggcagctttggaaaagacagccaaaaaggacagtaagaaaaaatcagatccc
agcagtcctgaccatggttcatcaacgattgagcaagatcttgctgccctagatgccgaa
atgacccaaaagctaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaacaatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggacaaaaaaaggcaggagaagata
acagaggctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggacgaaaagccc
aagctgcagatggacctggagcaagagtatcaagacaagttcaaaagactgcccctggag
atcttggagtttgtgcaggaagccatgaaagggaagatcagcgaagacagcaatcacagt
tctgcccctccctccctggcctcggagcctggaaaaatgaaccacaagcctccctccagt
gaggagctagaaggagacaacccaggaaaagagtttgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (6)   
   Pfam (6)   
All databases (23)   

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