KEGG   PATHWAY: zmo00010
Entry
zmo00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Zymomonas mobilis subsp. mobilis ZM4
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
zmo00010  Glycolysis / Gluconeogenesis
zmo00010

Module
zmo_M00002  Glycolysis, core module involving three-carbon compounds [PATH:zmo00010]
zmo_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:zmo00010]
Other DBs
GO: 0006096 0006094
Organism
Zymomonas mobilis subsp. mobilis ZM4 [GN:zmo]
Gene
ZMO0369  glucokinase [KO:K00845] [EC:2.7.1.2]
ZMO1212  Glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
ZMO0482  fructose-1,6-bisphosphatase, class II [KO:K11532] [EC:3.1.3.11 3.1.3.37]
ZMO0179  Fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
ZMO0465  Triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
ZMO0177  glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
ZMO0178  Phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
ZMO1240  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
ZMO1608  Phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
ZMO0152  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
ZMO1606  pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [KO:K00161] [EC:1.2.4.1]
ZMO1605  Transketolase central region [KO:K00162] [EC:1.2.4.1]
ZMO0510  pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
ZMO0512  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ZMO1360  thiamine pyrophosphate protein TPP binding domain protein [KO:K01568] [EC:4.1.1.1]
ZMO1722  S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
ZMO1236  Alcohol dehydrogenase zinc-binding domain protein [KO:K13953] [EC:1.1.1.1]
ZMO1596  iron-containing alcohol dehydrogenase [KO:K13954] [EC:1.1.1.1]
ZMO0889  Aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
zmo00020  Citrate cycle (TCA cycle)
zmo00030  Pentose phosphate pathway
zmo00500  Starch and sucrose metabolism
zmo00620  Pyruvate metabolism
zmo00640  Propanoate metabolism
KO pathway
ko00010   

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