+E Replication protein KO
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DNA Replication Proteins - Escherichia coli K-12 W3110
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
C GINS complex
C Other initiation factors
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
C DNA polymerase epsilon complex
C DNA polymerase delta complex
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
C RFC (replication factor C)
C RNase H
D JW0204 rnhA; ribonuclease HI, degrades RNA of DNA-RNA hybrids K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
C Other elongation factors
B DNA Replication Termination Factors
C DNA methylation enzymes
D JW1944 dcm; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D Dyskerin complex
C Telomerase complex (fungi)
D Sm core complex
C ELG1-RFC complex
C MRN complex
C Other termination factors
B DNA Topoisomerases
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D JW3964 hupA; HU, DNA-binding transcriptional regulator, alpha subunit K05787 hupA; DNA-binding protein HU-alpha
D JW0430 hupB; HU, DNA-binding transcriptional regulator, beta subunit K03530 hupB; DNA-binding protein HU-beta
D JW1702 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
D JW0895 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
D JW3679 dnaA; chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator K02313 dnaA; chromosomal replication initiator protein
D JW4012 dnaB; replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D JW4325 dnaC; DNA biosynthesis protein K02315 dnaC; DNA replication protein DnaC
D JW3038 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D JW4020 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
E JW0179 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E JW3678 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E JW4216 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E JW0635 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E JW1085 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E JW0205 dnaQ; DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E JW0459 dnaX; DNA polymerase III/DNA elongation factor III, tau and gamma subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E JW4334 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E JW1831 holE; DNA polymerase III, theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D RNase H
E JW0204 rnhA; ribonuclease HI, degrades RNA of DNA-RNA hybrids K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E JW0178 rnhB; ribonuclease HII, degrades RNA of DNA-RNA hybrids K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D Other elongation factors
E JW3835 polA; fused DNA polymerase I 5'->3' exonuclease, 3'->5' polymerase and 3'->5' exonuclease K02335 polA; DNA polymerase I [EC:2.7.7.7]
E JW2403 ligA; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E JW3622 ligB; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E JW0204 rnhA; ribonuclease HI, degrades RNA of DNA-RNA hybrids K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E JW0178 rnhB; ribonuclease HII, degrades RNA of DNA-RNA hybrids K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
B DNA Replication Termination Factors
C Terminus site-binding protein
D JW1602 tus; inhibitor of replication at Ter, DNA-binding protein K10748 tus; DNA replication terminus site-binding protein
C DNA methylation enzymes
D JW3350 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
C Prevention of re-replication factors
D JW0674 seqA; regulatory protein for replication initiation K03645 seqA; negative modulator of initiation of replication
D JW5397 hda; ATPase regulatory factor involved in DnaA inactivation K10763 hda; DnaA-homolog protein
B DNA Topoisomerases
C JW2225 gyrA; DNA gyrase (type II topoisomerase), subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C JW5625 gyrB; DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C JW2987 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
C JW2998 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
C JW1266 topA; DNA topoisomerase I, omega subunit K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
C JW1752 topB; DNA topoisomerase III K03169 topB; DNA topoisomerase III [EC:5.6.2.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022