+F Repair protein KO
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DNA Repair and Recombination Proteins - Candidatus Hamiltonella defensa (Acyrthosiphon pisum)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D HDEF_1277 phrB; deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E HDEF_0455 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E HDEF_1122 mpg_1; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HDEF_1323 mpg_2; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HDEF_0358 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E HDEF_1596 nth; DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D HDEF_0543 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HDEF_2318 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D HDEF_1277 phrB; deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E HDEF_0455 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E HDEF_1122 mpg_1; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HDEF_1323 mpg_2; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HDEF_0358 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E HDEF_1596 nth; DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E HDEF_0641 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E HDEF_1815 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
E HDEF_1619 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
E HDEF_1529 uvrC; excinuclease UvrABC, endonuclease subunit K03703 uvrC; excinuclease ABC subunit C
E HDEF_0700 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
E HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F HDEF_0711 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F HDEF_0710 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F HDEF_1841 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F HDEF_0625 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F HDEF_0121 mfd; transcription-repair ATP-dependent coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E HDEF_1628 mutS; methyl-directed mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E HDEF_0492 mutL_1; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
E HDEF_p0005 mutL; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
E HDEF_1386 mutL_2; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E HDEF_1904 mutH_1; putative methyl-directed mismatch repair protein with restriction endonuclease-like domain K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E HDEF_1920 sbcB; exonuclease I, 3' --> 5'-specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E HDEF_1282 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E HDEF_1606 xseB; exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D DNA ligase
E HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E HDEF_0700 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E HDEF_1639 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E HDEF_1167 vsr; DNA mismatch endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E HDEF_0033 recB; exonuclease V, beta chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E HDEF_0034 recC; exonuclease V, gamma chain with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E HDEF_0032 recD; exonuclease V (RecBCD complex), alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E HDEF_0025 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E HDEF_1940 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
E HDEF_1939 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E HDEF_0870 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E HDEF_0885 rus; endonuclease RUS K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E HDEF_0504 priA; primosomal protein N' (factor Y) directs replication fork assembly at D-loops, ATP-dependent K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E HDEF_0584 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E HDEF_1920 sbcB; exonuclease I, 3' --> 5'-specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
D RecFOR pathway proteins
E HDEF_0025 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E HDEF_1301 radA; DNA repair/recombination protein K04485 radA; DNA repair protein RadA/Sms
E HDEF_0627 recG; DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E HDEF_0534 recO; gap repair protein, part of RecFOR complex K03584 recO; DNA repair protein RecO (recombination protein O)
E HDEF_2089 recR; gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction K06187 recR; recombination protein RecR
E HDEF_0828 recN; protein used in recombination and DNA repair with nucleoside triphosphate hydrolase domain K03631 recN; DNA repair protein RecN (Recombination protein N)
E HDEF_0058 rgdC; putative ribonuclease K03554 rdgC; recombination associated protein RdgC
E HDEF_1940 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
E HDEF_1939 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E HDEF_0870 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F HDEF_1516 gyrA; DNA gyrase (type II topoisomerase), subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F HDEF_1742 gyrB; DNA gyrase, subunit B (type II topoisomerase) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F HDEF_1767 topA; DNA topoisomerase type I, omega protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F HDEF_p0014 hu; DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
F HDEF_1521 hupA_3; HU, DNA-binding transcriptional regulator, alpha subunit -3 K05787 hupA; DNA-binding protein HU-alpha
F HDEF_1162 hupB; DNA-binding protein HU-beta, NS1 (HU-1), plays a role in DNA replication and in rpo translation K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F HDEF_0534 recO; gap repair protein, part of RecFOR complex K03584 recO; DNA repair protein RecO (recombination protein O)
F HDEF_2089 recR; gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction K06187 recR; recombination protein RecR
F HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F HDEF_0367 fis; DNA-binding protein for site-specific recombination and inversion, transcription of rRNA and tRNA operons, and DNA replication K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F HDEF_1831 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
F HDEF_0697 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F HDEF_1920 sbcB; exonuclease I, 3' --> 5'-specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F HDEF_1815 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
F HDEF_1619 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
F HDEF_2063 hns; transcriptional regulator, DNA-binding protein HLP-II (HU, BH2, HD, NS), increases DNA thermal stability K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D HDEF_0025 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
D HDEF_0828 recN; protein used in recombination and DNA repair with nucleoside triphosphate hydrolase domain K03631 recN; DNA repair protein RecN (Recombination protein N)
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D HDEF_2303 rep; Rep helicase, a single-stranded DNA-dependent ATPase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
C Modulation of nucleotide pools
D HDEF_0543 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HDEF_2318 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D HDEF_0307 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HDEF_0306 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024