+D	Protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Membrane Trafficking - Natranaerobius thermophilus</h2>
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A<b>Exocytosis</b>
B  Calcium ion-dependent exocytosis
C    Synaptotagmins
C    Septins
C    DOC-2 proteins
C    Acrosomal exocytosis proteins
C    Phospholipases
C    Kinases and associated proteins
D      Nther_1605 nucleoside diphosphate kinase	K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] 
C    Others
B  Small GTPases and associated proteins
C    Rab GTPases
C    Rab associated proteins
C    Rho GTPases
C    Other small GTPases and associated proteins
B  Tethering complex
C    Exocyst complex
C    Exocyst complex assembly proteins
B  Others
C    Exomer complex
C    Others
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A<b>SNARE</b>
B  Syntaxin (Qa)
C    Stx-PM
C    Stx-Endo
C    Stx-TGN / EE
C    Stx-cisGolgi
C    Stx-sER
C    Stx-rER
B  SNAP-25[N] (Qb)
C    Vti1
C    NPSN
C    Gos1 (Gos28)
C    Bos1 / Membrin
C    Sec20
B  SNAP-25[C] (Qc)
C    STX6
C    STX8
C    STX10
C    Bet1
C    Sft1
C    Syp7
C    Use1
B  SNAP-25 (Qb,c)
C    SNAP-23
C    SNAP-25
C    SNAP-29
C    SNAP-47
B  VAMP, Ykt6, Sec22 (R)
C    VAMP
C    Ykt6
C    Sec22
C    Tomosyn
C    Putative SNAREs
B  SNARE associated proteins
C    Syntaxin-binding proteins
C    Palmitoyltransferases
C    Others
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A<b>Endocytosis</b>
B  Clathrin-mediated endocytosis
C    Clathrin
C    Dynamin
C    AP-2 complex
C    Other core components
C    Low-density lipoprotein receptor (LDLR) family proteins
C    LDLR adaptor proteins
C    GPCR adaptor proteins
C    Receptor tyrosine kinase (RTK) adaptor proteins
C    Inositol 5-phosphatases
C    Kinases
C    Ubiquitin E3 ligases
C    Others
B  Lipid raft mediated endocytosis
C    Caveolin-mediated endocytosis
C    Flotillin-dependent endocytosis
C    GRAF1-dependent endocytosis
C    Arf6-dependent endocytosis
C    RhoA-dependent endocytosis
B  Phagocytosis
C    Fc receptors
C    Integrins (complement receptors)
C    Opsonins
C    Toll-like receptors
C    C-lectin receptors
C    Scavenger receptors
C    Coronins
C    Others
B  Macropinocytosis
C    Ras GTPases
C    Kinases
C    Phospholipase C
C    Sorting nexins
C    Others
B  Bin/Amphiphysin/Rvs (BAR) family proteins
C    N-BAR proteins
C    F-BAR proteins
C    I-BAR proteins
B  Rab GTPases and associated proteins
C    Rab GTPases
C    Rab associated proteins
B  Arf GTPases and associated proteins
C    Arf GTPases
C    Arf associated proteins
B  Others
C    Fucosyltransferase
C    EFR3-PI4KIII alpha complex and associated proteins
C    Insulin-like growth factor-binding proteins
C    Others
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A<b>Endosome - Lysosome transport</b>
B  Rab GTPases and associated proteins
C    Rab GTPases
C    Retromer subcomplex
C    FTS/Hook/FHIP (FHF) complex
C    Rab associated proteins
B  Arf GTPases and associated proteins
C    Arf GTPases
C    BLOC-one-related complex (BORC)
C    N-acetyl transferase complex C (NatC)
C    Other Arf associated proteins
B  Endosomal sorting complexes required for transport (ESCRT)
C    ESCRT-0 complex
C    ESCRT-I complex
C    ESCRT-II complex
C    ESCRT-III complex
C    ESCRT associated proteins
B  Tethering complex
C    CORVET complex
C    Hops complex
B  Acidification regulators
C    Rabconnectin-3 complex
C    RAVE complex
B  Others
C    AP-3 complex
C    BLOC-1 complex
C    BLOC-1 complex (yeast)
C    BLOC-2 complex
C    BLOC-3 complex
C    Ferlins
C    Others
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A<b>Protein recycling</b>
B  Rab GTPases and associated proteins
C    Rab GTPases
C    Rab4 associated proteins
C    Rab11 associated proteins
C    Other Rab GTPase associated proteins
B  Others
C    Glutamate receptor-interacting proteins (GRIPs)
C    GRIP associated proteins
C    EARP complex
C    WASH complex
C    Retriever complex
C    Others
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A<b>Endosome - Golgi transport</b>
B  Rab GTPases and associated proteins
C    Rab GTPases
C    Rab associated proteins
B  Arf GTPases and associated proteins
C    Arf GTPases
C    Arf GTPase associated proteins
B  Tethering complex
C    Conserved oligomeric Golgi (COG) complex
C    GARP complex
C    TRAPP complex II
B  Others
C    AP-1 complex
C    AP-3 complex
C    AP-4 complex
C    GGA
C    Aftiphilin/p200/gamma-synergin complex
C    Others
D      Nther_1137 protein of unknown function UPF0016	K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family 
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A<b>Endoplasmic reticulum (ER) - Golgi transport</b>
B  Forward pathways
C    Coat protein complex II (COP-II)
C    TRAPP complex I
C    p24 family proteins
C    PDI family proteins
C    Rab GTPases
C    Rab associated proteins
C    ER-Golgi intermediate compartment (ERGIC) proteins
B  Retrieval pathways
C    Coat protein complex I (COP-I)
C    NRZ (DSL1) complex
C    Golgi to ER traffic proteins (GET)
C    Rab GTPases
C    Rab associated proteins
B  Others
C    Oxysterol-binding proteins
C    FXYD proteins
C    YIPF proteins
C    ER membrane protein complex
C    SEC61 complex
C    TRAP complex
C    Multi-pass translocon (MPT) complex
C    Post-GPI attachment to proteins factors (PGAP)
C    Others
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A<b>Autophagy</b>
B  Autophagosome formation proteins
C    ULK complex
C    Atg1 complex
C    PI3K complex
C    ATG9 transmembrane protein
C    Atg18-Atg2 complex
C    Atg12 conjugation proteins
C    Atg8 conjugation proteins
B  Cytoplasm to vacuolar targeting (CVT) pathway
C    Selective cargos
C    Cargo receptors
C    Scaffold protein
C    Other Cvt associated proteins
B  Mitophagy
C    Cargo receptors
C    Scaffold proteins
C    PINK1-Parkin associated proteins
C    Other mitophagy associated  proteins
B  Pexophagy
C    Selective cargos
C    Cargo receptors
C    Other pexophagy associated proteins
B  Aggrephagy
C    Cargo receptors
C    Scaffold proteins
C    Other aggrephagy associated proteins
B  Xenophagy
C    Cargo receptors
C    Other xenophagy associated proteins
B  Chaperone mediated autophagy (CMA)
C    Selective cargos
D      Nther_2342 glyceraldehyde-3-phosphate dehydrogenase	K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] 
D      Nther_2427 glyceraldehyde-3-phosphate dehydrogenase	K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] 
D      Nther_0550 pyruvate kinase	K00873 PK; pyruvate kinase [EC:2.7.1.40] 
C    Cargo receptors
C    Chaperones
D      Nther_0856 heat shock protein Hsp90	K04079 HSP90A; molecular chaperone HtpG 
C    Co-chaperones
C    Other CMA associated proteins
B  Other autophagy associated proteins
C    RNautophagy/DNautophagy
C    Micronucleophagy
C    Midbophagy
C    Glycophagy
C    TRIM-directed selective autophagy
C    ER-mitochondria tethering complex
C    mTORC1 complex
C    mTORC2 complex
C    SEACIT/GATOR1 complex
C    SEACAT/GATOR2 complex
C    KICSTOR complex
C    Rab GTPases
C    Rab associated proteins
C    Others
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A<b>Others</b>
B  NADPH oxidases (Nox) and associated proteins
C    NADPH oxidases
C    Nox associated proteins
B  Actin-binding proteins
C    Myosins
C    Arp2/3 complex
C    Nucleation-promoting factors (NPFs)
C    Others
B  Mucins
C    Membrane bound mucins
C    Secretory mucins
B  Rab GTPases of specific organelles
C    Melanosome
C    Auto phagosome
C    Lipid droplets
C    Mitochondrion
B  Rho GTPase associated proteins
C    Rho GTPase-activating proteins
C    Rho guanine nucleotide exchange factors (GEFs)
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#Last updated: April 10, 2024