KEGG   DRUG: D00494Help
Entry
D00494                      Drug                                   

Name
Promethazine (JAN/INN)
Formula
C17H20N2S
Exact mass
284.1347
Mol weight
284.4191
Structure
Mol fileKCF fileDB searchJmolKegDraw
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Remark
Same as: 
ATC code: 
Chemical structure group: 
Product (DG00385): 
D00480<JP/US> D03290<JP> D08768<JP>
BRITE hierarchy
Comment
Phenothiazine derivative
Structure map
map07028  Antipsychotics
map07029  Antipsychotics - phenothiazines
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
map07213  Dopamine receptor agonists/antagonists
Other DBs
CAS: 
60-87-7
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Hide
ATOM        20
            1   N1y N    25.3291  -19.1045
            2   C8y C    26.5689  -19.8030
            3   C8y C    24.1359  -19.8030
            4   C1b C    25.3291  -17.6902
            5   C8y C    26.5689  -21.2116
            6   C8x C    27.7621  -19.1045
            7   C8y C    24.1359  -21.2116
            8   C8x C    22.9369  -19.1045
            9   C1c C    26.5340  -17.0033
            10  S2x S    25.3291  -21.9041
            11  C8x C    27.7621  -21.9041
            12  C8x C    28.9670  -19.8030
            13  C8x C    22.9369  -21.9041
            14  C8x C    21.6971  -19.8030
            15  N1c N    26.5340  -15.6820
            16  C1a C    27.7272  -17.6902
            17  C8x C    28.9670  -21.2116
            18  C8x C    21.6971  -21.2116
            19  C1a C    25.1953  -14.9079
            20  C1a C    27.6690  -14.9428
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15    9  16 1
            16   11  17 2
            17   13  18 2
            18   15  19 1
            19   15  20 1
            20    7  10 1
            21   12  17 1
            22   14  18 1

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