Target-based Classification of Drugs

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 G Protein-coupled receptors
 
 Ion channels
   Ligand-gated ion channels
   Voltage-gated ion channels
     Sodium channels
     Calcium channels
       CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
         D08217  Mibefradil (INN)
         D05024  Mibefradil dihydrochloride (USAN)
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D00539  Ethosuximide (JP18/USP/INN) <JP/US>
         D00404  Methsuximide (USP) <US>
         D00399  Valproic acid (USP) <US>
         D00304  Divalproex sodium (USP) <US>
         D00710  Valproate sodium (USAN) <JP/US>
         D08667  Calcium valproate
         D00538  Zonisamide (JP18/USP/INN) <JP/US>
         D02630  Penfluridol (USAN/INN)
         D07971  Flunarizine (INN)
         D01303  Flunarizine hydrochloride (JAN/USAN)
         D02633  Lomerizine hydrochloride (JAN) <JP>
         D12061  Suvecaltamide (USAN)
         D12062  Suvecaltamide hydrocloride (USAN)
         D12819  Ulixacaltamide (USAN/INN)
         D12820  Ulixacaltamide hydrochloride (USAN)
       CACNA1B [HSA:774] [KO:K04849]
       CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D07845  Diltiazem (INN)
         D00616  Diltiazem hydrochloride (JP18/USP) <JP/US>
         D03830  Diltiazem malate (USAN)
         D01369  Bevantolol hydrochloride (JAN/USAN) <JP>
         D07450  Amlodipine (USP/INN)
         D00615  Amlodipine besylate (USP) <JP/US>
         D02914  Amlodipine maleate (USAN)
         D11881  Amlodipine benzoate <US>
         D00319  Felodipine (JP18/USP/INN) <JP/US>
         D00349  Isradipine (USP/INN) <US>
         D08270  Nicardipine (INN)
         D00617  Nicardipine hydrochloride (JP18/USAN) <JP/US>
         D00437  Nifedipine (JP18/USP/INN) <JP/US>
         D00438  Nimodipine (USP/INN) <US>
         D00618  Nisoldipine (JAN/USAN/INN) <US>
         D00629  Nitrendipine (JP18/USAN/INN) <JP>
         D04657  Lacidipine (USAN/INN)
         D01908  Nilvadipine (JP18/USAN/INN) <JP>
         D08155  Manidipine (INN)
         D01553  Manidipine hydrochloride (JP18) <JP>
         D07494  Barnidipine (INN)
         D01104  Barnidipine hydrochloride (JAN) <JP>
         D08111  Lercanidipine (INN)
         D01849  Lercanidipine hydrochloride (JAN/USAN)
         D01173  Cilnidipine (JP18/INN) <JP>
         D07509  Benidipine (INN)
         D02045  Benidipine hydrochloride (JP18) <JP>
         D08892  Clevidipine (USAN/INN) <US>
         D08941  Levamlodipine malate (USAN)
         D11723  Levamlodipine maleate (USAN) <US>
         D08217  Mibefradil (INN)
         D05024  Mibefradil dihydrochloride (USAN)
         D02356  Verapamil (USAN/INN)
         D00619  Verapamil hydrochloride (JP18/USP) <JP/US>
         D08009  Gallopamil (INN)
         D01969  Gallopamil hydrochloride (JAN)
         D07185  Fendiline (INN)
         D07943  Fendiline hydrochloride
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D08340  Perhexiline (INN)
         D05442  Perhexiline maleate (USAN)
         D08441  Propiverine (INN)
         D01007  Propiverine hydrochloride (JP18) <JP>
         D00495  Paramethadione (INN)
         D00537  Topiramate (JAN/USP/INN) <JP/US>
         D01145  Azelnidipine (JP18/INN) <JP>
         D01151  Lemildipine (JAN/INN)
         D01171  Monatepil maleate (JAN/USAN)
         D01562  Aranidipine (JAN/INN)
         D01604  Efonidipine hydrochloride ethanolate (JAN) <JP>
         D01933  Vatanidipine hydrochloride (JAN)
         D03067  Belfosdil (USAN/INN)
         D03536  Clentiazem maleate (JAN/USAN)
         D03655  Darodipine (USAN/INN)
         D04193  Flordipine (USAN/INN)
         D04260  Fostedil (USAN/INN)
         D06129  Tiapamil hydrochloride (USAN)
         D07886  Efonidipine (INN)
         D09789  Kirenidipine hydrochloride (JAN)
         D09833  Levosemotiadil fumarate (JAN)
         D10932  Etripamil (USAN/INN)
         D11102  Tamolarizine hydrochloride (JAN)
       CACNA1S [HSA:779] [KO:K04857]
       CACNA2D [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861]
       CACNA2D1 [HSA:781] [KO:K04858]
       CACNA2D2 [HSA:9254] [KO:K04859]
     Potassium channels
       KCNA [HSA:3736 3737 3738 3739 3741 3742 3743 3744] [KO:K04874 K04875 K04876 K04877 K04878 K04879 K04880 K04881]
       KCNA1 [HSA:3736] [KO:K04874]
       KCNA5 [HSA:3741] [KO:K04878]
         D06665  Vernakalant hydrochloride (USAN)
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
       KCNB [HSA:3745 9312] [KO:K04885 K04886]
       KCNC [HSA:3746 3747 3748 3749] [KO:K04887 K04888 K04889 K04890]
       KCND [HSA:3750 3751 3752] [KO:K04891 K04892 K04893]
       KCND3 [HSA:3752] [KO:K04893]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D06665  Vernakalant hydrochloride (USAN)
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D01856  Nifekalant hydrochloride (JAN) <JP>
       KCNH1 [HSA:3756] [KO:K04904]
       KCNH2 [HSA:3757] [KO:K04905]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D00647  Dofetilide (JAN/USP/INN) <US>
         D08060  Ibutilide (INN)
         D00648  Ibutilide fumarate (USP) <US>
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D08525  Sotalol (INN)
         D01026  Sotalol hydrochloride (JAN/USP) <JP/US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D00110  Cocaine (USP)
         D02182  Cocaine hydrochloride (JP18/USP) <US>
         D00521  Terfenadine (JAN/USAN/INN)
         D01856  Nifekalant hydrochloride (JAN) <JP>
         D03037  Azimilide dihydrochloride (USAN)
         D03547  Clofilium phosphate (USAN/INN)
         D03732  Dexsotalol hydrochloride (USAN)
         D04955  Sematilide hydrochloride (USAN)
         D06206  Trecetilide fumarate (USAN)
         D09757  Terikalant (INN)
         D09758  Ambasilide (INN)
         D09759  Trecetilide (INN)
       KCNQ [HSA:3784 3785 3786 9132 56479] [KO:K04926 K04927 K04928 K04929 K04930]
       KCNQ1 [HSA:3784] [KO:K04926]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D03037  Azimilide dihydrochloride (USAN)
         D09757  Terikalant (INN)
         D09758  Ambasilide (INN)
       KCNMB1 [HSA:3779] [KO:K04937]
       KCNN4 [HSA:3783] [KO:K04945]
       KCNT2 (SLICK) [HSA:343450] [KO:K04947]
     Inward rectifier channels (Kir)
       KCNJ1 [HSA:3758] [KO:K04995]
       KCNJ3 [HSA:3760] [KO:K04997]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
       KCNJ5 [HSA:3762] [KO:K04999]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D02537  Dronedarone (INN)
         D03914  Dronedarone hydrochloride (USP) <US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
       KCNJ8 [HSA:3764] [KO:K05001]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
       KCNJ11 [HSA:3767] [KO:K05004]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D03914  Dronedarone hydrochloride (USP) <US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
       KCNJ12 [HSA:3768] [KO:K05005]
         D02910  Amiodarone (USAN/INN)
         D00636  Amiodarone hydrochloride (JP18/USP) <JP/US>
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D01856  Nifekalant hydrochloride (JAN) <JP>
         D09757  Terikalant (INN)
     Ryanodine receptors (RYR)
     Transient receptor potential channels
   Other ion channels
 
 Nuclear receptors
 
 Protein kinases
 
 Cytokines and receptors
 
 Cell surface molecules and ligands
 
 Transporters
 
 Enzymes
   Oxidoreductases (EC1)
   Transferases (EC2)
   Hydrolases (EC3)
     Carboxylic-ester hydrolases [EC:3.1.1.-]
     Phosphatases [EC:3.1.3.-]
     Phosphodiesterases [EC:3.1.4.-]
     Sulfatases [EC:3.1.6.-]
     Glycosidases [EC:3.2.1.-]
     ADP-ribosyl cyclase [EC:3.2.2.6]
     Aminopeptidases [EC:3.4.11.-]
     Dipeptidases [EC:3.4.13.-]
     Peptidyl-peptidases [EC:3.4.14.-]
     Peptidyl-dipeptidases [EC:3.4.15.-]
     Metallocarboxypeptidases [EC:3.4.17.-]
     Serine peptidases [EC:3.4.21.-]
     Cysteine peptidases [EC:3.4.22.-]
     Aspartic peptidases [EC:3.4.23.-]
     Metallo peptidases [EC:3.4.24.- 3.4.17.-]
     Threonine peptidases [EC:3.4.25.-]
     Glutaminase [EC:3.5.1.2]
     Histone deacetylase [EC:3.5.1.98]
     Arginase [EC:3.5.3.1]
     Adenosine deaminase [EC:3.5.4.4]
     Cytidine deaminase [EC:3.5.4.5]
     ATPase [EC:3.6.3.-]
       ATP1A [HSA:476 477 478 480] [KO:K01539]
         D06881  Acetyldigitoxin (INN)
         D07555  Acetyldigoxin
         D00297  Digitoxin (JAN/USP/INN)
         D00298  Digoxin (JP18/USP) <JP/US>
         D01972  Lanatoside C (JAN/INN)
         D01240  Deslanoside (JP18/USP/INN) <JP>
         D09847  Metildigoxin (INN)
         D02587  Metildigoxin (JP18) <JP>
         D07147  Gitoformate (INN)
         D01379  Proscillaridin (JAN/USAN/INN)
         D00112  G-Strophanthin (JAN)
         D00645  Bretylium tosylate (USP)
         D07520  Bepridil (INN)
         D00631  Bepridil hydrochloride (USAN) <JP>
         D07556  beta-Acetyldigoxin
       ATP2A [HSA:487 488 489] [KO:K05853]
       ATP4 [HSA:495 496] [KO:K01542 K01543]
       ABCB1 (CD243) [HSA:5243] [KO:K05658]
   Lyases (EC4)
   Isomerases (EC5)
   Ligases (EC6)
 
 Nucleic acids
 
 Not elsewhere classified

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Last updated: April 17, 2024

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