Target-based Classification of Drugs

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     Type
 G Protein-coupled receptors
   Rhodopsin family
     Acetylcholine (muscarinic)
     Adrenaline
     Dopamine
     Histamine
     Serotonin
     Angiotensin
     Bradykinin
     Cholecystokinin
     Endothelin
     Follicle stimulating hormone
     Ghrelin
     Gonadotropin-releasing hormone
     Lutropin-choriogonadotropic hormone
     Melanocortin
     Motilin
     Neuropeptide Y
     Opioid
       OPRM1 [HSA:4988] [KO:K04215]
         D08639  Trimebutine (INN)
         D01500  Trimebutine maleate (JP17) <JP>
         D06618  Methylnaltrexone bromide (JAN/USAN) <US>
         D02878  Alvimopan (USAN) <US>
         D10479  Naloxegol (USAN/INN)
         D10375  Naloxegol oxalate (USAN) <US>
         D08249  Naloxone (INN)
         D01340  Naloxone hydrochloride (JP17/USP) <JP/US>
         D10188  Naldemedine (USAN/INN)
         D10478  Naldemedine tosylate (JAN/USAN) <JP/US>
         D07861  Diphenoxylate (INN)
         D03860  Diphenoxylate hydrochloride (USP)
         D08144  Loperamide (INN)
         D00729  Loperamide hydrochloride (JAN/USP) <JP/US>
         D03809  Difenoxin (USAN/INN)
         D07113  Loperamide oxide (INN)
         D10403  Eluxadoline (USAN) <US>
         D00320  Fentanyl (JAN/USAN/INN) <JP/US>
         D01399  Fentanyl citrate (JP17/USP) <JP/US>
         D10811  Fentanyl hydrochloride (JAN) <US>
         D07122  Alfentanil (INN)
         D00835  Alfentanil hydrochloride (USP) <US>
         D05938  Sufentanil (USAN/INN)
         D00845  Sufentanil citrate (USP) <US>
         D02941  Anileridine (USP/INN)
         D02942  Anileridine hydrochloride (USP)
         D08473  Remifentanil (INN)
         D01177  Remifentanil hydrochloride (JAN/USAN) <JP/US>
         D08233  Morphine (BAN)
         D00842  Morphine sulfate (USP) <JP/US>
         D02271  Morphine hydrochloride hydrate (JP17) <JP>
         D08234  Morphine tartrate
         D08047  Hydromorphone (INN)
         D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
         D07285  Nicomorphine (INN)
         D08273  Nicomorphine hydrochloride
         D05312  Oxycodone (USAN/INN)
         D00847  Oxycodone hydrochloride (USP) <US>
         D03783  Oxycodone terephthalate (USP)
         D05462  Oxycodone hydrochloride hydrate (JP17) <JP>
         D07831  Dihydrocodeine (INN)
         D01481  Dihydrocodeine phosphate (JP17) <JP>
         D03825  Dihydrocodeine bitartrate (USP)
         D07832  Dihydrocodeine thiocyanate
         D08100  Ketobemidone (INN)
         D08101  Ketobemidone hydrochloride
         D08343  Pethidine (INN)
         D01383  Meperidine hydrochloride (USP) <JP/US>
         D07809  Dextropropoxyphene (INN)
         D00482  Propoxyphene hydrochloride (USP) <US>
         D05632  Propoxyphene napsylate (USAN)
         D00498  Pentazocine (JP17/USP/INN) <JP>
         D02111  Pentazocine lactate (USP)
         D02227  Pentazocine hydrochloride (JAN/USP) <JP>
         D07132  Buprenorphine (JAN/INN) <JP/US>
         D00836  Buprenorphine hydrochloride (JP17/USP) <JP/US>
         D03197  Butorphanol (USAN/INN)
         D00837  Butorphanol tartrate (JAN/USP) <US>
         D08246  Nalbuphine (INN)
         D00843  Nalbuphine hydrochloride (USAN) <US>
         D08597  Tilidine (INN)
         D06147  Tilidine hydrochloride (USAN)
         D08623  Tramadol (INN)
         D01355  Tramadol hydrochloride (JP17/USAN) <JP/US>
         D00838  Dezocine (USAN)
         D08182  Meptazinol (INN)
         D04924  Meptazinol hydrochloride (USAN)
         D06007  Tapentadol (USAN/INN)
         D10199  Tapentadol hydrochloride (JAN) <JP/US>
         D05113  Naltrexone (USAN/INN) <US>
         D02095  Naltrexone hydrochloride (USP) <US>
         D05111  Nalmefene (USAN/INN)
         D02104  Nalmefene hydrochloride
         D10812  Nalmefene hydrochloride hydrate (JAN) <JP>
         D08195  Methadone (BAN)
         D02102  Methadone hydrochloride (JAN/USP) <JP/US>
         D04716  Levomethadyl acetate (USAN)
         D00840  Levomethadyl acetate hydrochloride (USAN)
         D08121  Levomethadone (INN)
         D08122  Levomethadone hydrochloride
         D07286  Diamorphine (BAN)
         D07810  Diacetylmorphine hydrochloride
         D07929  Ethylmorphine (BAN)
         D02205  Ethylmorphine hydrochloride hydrate (JP17)
         D08045  Hydrocodone (INN)
         D03725  Hydrocodone bitartrate (USP) <US>
         D04461  Hydrocodone polistirex (USAN)
         D08046  Hydrocodone hydrochloride
         D00195  Codeine (USP)
         D02101  Codeine phosphate (USP) <JP>
         D03579  Codeine polistirex (USAN)
         D03580  Codeine sulfate (USP) <US>
         D07740  Codeine hydrochloride
         D07385  Pholcodine (INN)
         D07557  O-Acetyldihydrocodeine hydrochloride
         D08247  Nalorphine (INN)
         D08248  Nalorphine hydrochloride (USP)
         D00841  Levorphanol tartrate (USP) <US>
         D00844  Oxymorphone hydrochloride (USP) <US>
         D01435  Ethoheptazine citrate (JAN)
         D01879  Eptazocine hydrobromide (JAN) <JP>
         D02238  Levallorphan tartrate (JP17) <JP>
         D03156  Brifentanil hydrochloride (USAN)
         D03405  Carfentanil citrate (USAN)
         D03618  Cyclazocine (USAN/INN)
         D04764  Lofentanil oxalate (USAN)
         D04973  Methadyl acetate (USAN)
         D05048  Mirfentanil hydrochloride (USAN)
         D05217  Ocfentanil hydrochloride (USAN)
         D05631  Propiram fumarate (USAN)
         D05667  Quadazocine mesylate (USAN)
         D06189  Tonazocine mesylate (USAN)
         D06208  Trefentanil hydrochloride (USAN)
         D06268  Trimeperidine (INN)
         D06342  Xorphanol mesylate (USAN)
         D07620  Carfentanil (INN)
         D07863  Diprenorphine (INN)
         D07864  Diprenorphine hydrochloride
         D07904  Eptazocine (INN)
         D07937  Etorphine (INN)
         D08123  Levorphanol (INN)
         D08323  Oxymorphone (INN)
         D10162  Samidorphan (USAN)
         D10163  Samidorphan l-malate (USAN)
         D10349  Bevenopran (USAN/INN)
         D10371  Methylsamidorphan (USAN)
         D10436  Cebranopadol (USAN/INN)
         D10612  Benzhydrocodone (USAN/INN)
         D10648  Methylsamidorphan chloride (USAN/INN)
         D10690  Axelopran sulfate (USAN)
         D10692  Benzhydrocodone hydrochloride (USAN)
         D10740  Axelopran (USAN/INN)
         D11214  Oliceridine (USAN/INN)
         D11291  Asalhydromorphone (USAN)
         D11292  Asalhydromorphone hydrochloride (USAN)
         D11424  Oxycodegol (USAN)
         D11425  Oxycodegol phosphate (USAN)
         D11583  Difenoxin hydrochloride
         D11620  Naloxone hydrochloride dihydrate
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
       OPRK1 [HSA:4986] [KO:K04214]
       OPRD1 [HSA:4985] [KO:K04213]
       OPRL1 [HSA:4987] [KO:K04216]
     Orexin
     Oxytocin
     Relaxin
     Somatostatin
     Tachykinin
     Thrombin
     Thyrotropin-releasing hormone
     Vasopressin
     Purine / pyrimidine
     Adenosine
     Cysteinyl leukotriene
     Free fatty acid
     Leukotriene
     Prostaglandin
     Prostacyclin
     Sphingolipid
     Thromboxane
     Cannabinoid
     Melatonin
     Platelet activating factor
   Secretin receptor family
   Metabotropic glutamate receptor family
   Frizzled / Smoothened family
 
 Ion channels
   Ligand-gated ion channels
     Acetylcholine (nicotinic)
     Serotonin
     GABA (ionotropic)
     Glycine
     Glutamate (ionotropic), non-NMDA
     Glutamate (ionotropic), NMDA
       GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906 116443 116444] [KO:K05208 K05209 K05210 K05211 K05212 K05213 K05214]
       GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
         D08098  Ketamine (INN)
         D00711  Ketamine hydrochloride (JP17/USP) <JP/US>
         D07283  Esketamine (USAN/INN)
         D10627  Esketamine hydrochloride (USAN) <US>
         D07441  Amantadine (INN)
         D00777  Amantadine hydrochloride (JP17/USP) <JP/US>
         D07306  Budipine (INN)
         D07589  Budipine hydrochloride
         D08174  Memantine (INN)
         D04905  Memantine hydrochloride (JAN/USAN) <JP/US>
         D07058  Acamprosate (INN)
         D02780  Acamprosate calcium (JAN/USAN) <JP/US>
         D08195  Methadone (BAN)
         D02102  Methadone hydrochloride (JAN/USP) <JP/US>
         D08121  Levomethadone (INN)
         D08122  Levomethadone hydrochloride
         D00775  Riluzole (JAN/USAN/INN) <JP/US>
         D03742  Dextromethorphan (USP)
         D00848  Dextromethorphan hydrobromide (USP) <JP>
         D03744  Dextromethorphan polistirex (USAN)
         D02410  Selfotel (USAN/INN)
         D02973  Aptiganel hydrochloride (USAN)
         D03679  Delucemine hydrochloride (USAN)
         D03746  Dextrorphan hydrochloride (USAN)
         D03878  Dizocilpine maleate (USAN)
         D04308  Gavestinel (USAN/INN)
         D04728  Licostinel (USAN/INN)
         D05447  Perzinfotel (USAN/INN)
         D05453  Phencyclidine hydrochloride (USAN)
         D05714  Remacemide hydrochloride (USAN)
         D06146  Tiletamine hydrochloride (USP)
         D08596  Tiletamine (INN)
         D09917  Latrepirdine (USAN/INN)
         D09918  Latrepirdine dihydrochloride (USAN)
         D11299  Apimostinel (USAN)
         D11414  Troriluzole (USAN)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
       GRIN2B (NMDAR2B) [HSA:2904] [KO:K05210]
     Epithelial sodium channel (SCNN)
     ATP-gated cation channel (P2X)
   Voltage-gated ion channels
   Other ion channels
 
 Nuclear receptors
 
 Protein kinases
 
 Cytokines and receptors
 
 Cell surface molecules and ligands
 
 Transporters
 
 Enzymes
 
 Nucleic acids
 
 Not elsewhere classified

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Last updated: October 12, 2019

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