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09100 Metabolism
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09120 Genetic Information Processing
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09130 Environmental Information Processing
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09140 Cellular Processes
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09181 Protein families: metabolism
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09182 Protein families: genetic information processing
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03000 Transcription factors [BR:hsa03000]
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03021 Transcription machinery [BR:hsa03021]
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03019 Messenger RNA biogenesis [BR:hsa03019]
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03041 Spliceosome [BR:hsa03041]
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03011 Ribosome [BR:hsa03011]
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03009 Ribosome biogenesis [BR:hsa03009]
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03016 Transfer RNA biogenesis [BR:hsa03016]
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03012 Translation factors [BR:hsa03012]
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03110 Chaperones and folding catalysts [BR:hsa03110]
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04131 Membrane trafficking [BR:hsa04131]
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04121 Ubiquitin system [BR:hsa04121]
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03051 Proteasome [BR:hsa03051]
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03032 DNA replication proteins [BR:hsa03032]
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4998 ORC1; origin recognition complex subunit 1
4999 ORC2; origin recognition complex subunit 2
23595 ORC3; origin recognition complex subunit 3
5000 ORC4; origin recognition complex subunit 4
5001 ORC5; origin recognition complex subunit 5
23594 ORC6; origin recognition complex subunit 6
81620 CDT1; chromatin licensing and DNA replication factor 1
990 CDC6; cell division cycle 6
4171 MCM2; minichromosome maintenance complex component 2
4172 MCM3; minichromosome maintenance complex component 3
4173 MCM4; minichromosome maintenance complex component 4
4174 MCM5; minichromosome maintenance complex component 5
4175 MCM6; minichromosome maintenance complex component 6
4176 MCM7; minichromosome maintenance complex component 7
890 CCNA2; cyclin A2
8900 CCNA1; cyclin A1
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
1017 CDK2; cyclin dependent kinase 2
8317 CDC7; cell division cycle 7
10926 DBF4; DBF4-CDC7 kinase regulatory subunit
80174 DBF4B; DBF4B-CDC7 kinase regulatory subunit
9837 GINS1; GINS complex subunit 1
51659 GINS2; GINS complex subunit 2
64785 GINS3; GINS complex subunit 3
84296 GINS4; GINS complex subunit 4
11073 TOPBP1; DNA topoisomerase II binding protein 1
9401 RECQL4; RecQ like helicase 4
8318 CDC45; cell division cycle 45
84515 MCM8; minichromosome maintenance 8 homologous recombination repair factor
254394 MCM9; minichromosome maintenance 9 homologous recombination repair factor
55388 MCM10; minichromosome maintenance 10 replication initiation factor
92797 HELB; DNA helicase B
63901 FAM111A; FAM111 trypsin like peptidase A
51550 CINP; cyclin dependent kinase 2 interacting protein
27085 MTBP; MDM2 binding protein
90381 TICRR; TOPBP1 interacting checkpoint and replication regulator
5422 POLA1; DNA polymerase alpha 1, catalytic subunit
23649 POLA2; DNA polymerase alpha 2, accessory subunit
5557 PRIM1; DNA primase subunit 1
5558 PRIM2; DNA primase subunit 2
5426 POLE; DNA polymerase epsilon, catalytic subunit
5427 POLE2; DNA polymerase epsilon 2, accessory subunit
54107 POLE3; DNA polymerase epsilon 3, accessory subunit
56655 POLE4; DNA polymerase epsilon 4, accessory subunit
5424 POLD1; DNA polymerase delta 1, catalytic subunit
5425 POLD2; DNA polymerase delta 2, accessory subunit
10714 POLD3; DNA polymerase delta 3, accessory subunit
57804 POLD4; DNA polymerase delta 4, accessory subunit
5428 POLG; DNA polymerase gamma, catalytic subunit
11232 POLG2; DNA polymerase gamma 2, accessory subunit
6117 RPA1; replication protein A1
6118 RPA2; replication protein A2
6119 RPA3; replication protein A3
29935 RPA4; replication protein A4
5981 RFC1; replication factor C subunit 1
5984 RFC4; replication factor C subunit 4
5982 RFC2; replication factor C subunit 2
5985 RFC5; replication factor C subunit 5
5983 RFC3; replication factor C subunit 3
246243 RNASEH1; ribonuclease H1
10535 RNASEH2A; ribonuclease H2 subunit A
79621 RNASEH2B; ribonuclease H2 subunit B
84153 RNASEH2C; ribonuclease H2 subunit C
5111 PCNA; proliferating cell nuclear antigen
1763 DNA2; DNA replication helicase/nuclease 2
2237 FEN1; flap structure-specific endonuclease 1
9156 EXO1; exonuclease 1
84083 ZRANB3; zinc finger RANBP2-type containing 3
3978 LIG1; DNA ligase 1
79915 ATAD5; ATPase family AAA domain containing 5
1786 DNMT1; DNA methyltransferase 1
1788 DNMT3A; DNA methyltransferase 3 alpha
1789 DNMT3B; DNA methyltransferase 3 beta
51053 GMNN; geminin DNA replication inhibitor
345643 MCIDAS; multiciliate differentiation and DNA synthesis associated cell cycle protein
891 CCNB1; cyclin B1
9133 CCNB2; cyclin B2
85417 CCNB3; cyclin B3
983 CDK1; cyclin dependent kinase 1
25913 POT1; protection of telomeres 1
7013 TERF1; telomeric repeat binding factor 1
7014 TERF2; telomeric repeat binding factor 2
26277 TINF2; TERF1 interacting nuclear factor 2
54386 TERF2IP; TERF2 interacting protein
65057 ACD; ACD shelterin complex subunit and telomerase recruitment factor
283847 TERB1; telomere repeat binding bouquet formation protein 1
145645 TERB2; telomere repeat binding bouquet formation protein 2
283129 MAJIN; membrane anchored junction protein
80169 CTC1; CST telomere replication complex component 1
79991 STN1; STN1 subunit of CST complex
100134934 TEN1; TEN1 subunit of CST complex
23293 SMG6; SMG6 nonsense mediated mRNA decay factor
23381 SMG5; SMG5 nonsense mediated mRNA decay factor
7015 TERT; telomerase reverse transcriptase
7011 TEP1; telomerase associated protein 1
54433 GAR1; GAR1 ribonucleoprotein
55651 NHP2; NHP2 ribonucleoprotein
55505 NOP10; NOP10 ribonucleoprotein
1736 DKC1; dyskerin pseudouridine synthase 1
6628 SNRPB; small nuclear ribonucleoprotein polypeptides B and B1
6632 SNRPD1; small nuclear ribonucleoprotein D1 polypeptide
6633 SNRPD2; small nuclear ribonucleoprotein D2 polypeptide
6634 SNRPD3; small nuclear ribonucleoprotein D3 polypeptide
6635 SNRPE; small nuclear ribonucleoprotein polypeptide E
6636 SNRPF; small nuclear ribonucleoprotein polypeptide F
6637 SNRPG; small nuclear ribonucleoprotein polypeptide G
4361 MRE11; MRE11 homolog, double strand break repair nuclease
10111 RAD50; RAD50 double strand break repair protein
4683 NBN; nibrin
472 ATM; ATM serine/threonine kinase
7486 WRN; WRN RecQ like helicase
641 BLM; BLM RecQ like helicase
5591 PRKDC; protein kinase, DNA-activated, catalytic subunit
2072 ERCC4; ERCC excision repair 4, endonuclease catalytic subunit
142 PARP1; poly(ADP-ribose) polymerase 1
10038 PARP2; poly(ADP-ribose) polymerase 2
10039 PARP3; poly(ADP-ribose) polymerase family member 3
143 PARP4; poly(ADP-ribose) polymerase family member 4
8658 TNKS; tankyrase
80351 TNKS2; tankyrase 2
54984 PINX1; PIN2 (TERF1) interacting telomerase inhibitor 1
51750 RTEL1; regulator of telomere elongation helicase 1
9894 TELO2; telomere maintenance 2
79002 TRIR; telomerase RNA component interacting RNase
55183 RIF1; replication timing regulatory factor 1
80119 PIF1; PIF1 5'-to-3' DNA helicase
5813 PURA; purine rich element binding protein A
29942 PURG; purine rich element binding protein G
55135 WRAP53; WD repeat containing antisense to TP53
163859 SDE2; SDE2 telomere maintenance homolog
51507 RTF2; replication termination factor 2
7150 TOP1; DNA topoisomerase I
116447 TOP1MT; DNA topoisomerase I mitochondrial
7155 TOP2B; DNA topoisomerase II beta
7153 TOP2A; DNA topoisomerase II alpha
7156 TOP3A; DNA topoisomerase III alpha
8940 TOP3B; DNA topoisomerase III beta
6742 SSBP1; single stranded DNA binding protein 1
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K02603 ORC1; origin recognition complex subunit 1
K02604 ORC2; origin recognition complex subunit 2
K02605 ORC3; origin recognition complex subunit 3
K02606 ORC4; origin recognition complex subunit 4
K02607 ORC5; origin recognition complex subunit 5
K02608 ORC6; origin recognition complex subunit 6
K10727 CDT1; chromatin licensing and DNA replication factor 1
K02213 CDC6; cell division control protein 6
K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
K06629 DBF4; protein DBF4
K06629 DBF4; protein DBF4
K10732 GINS1; GINS complex subunit 1
K10733 GINS2; GINS complex subunit 2
K10734 GINS3; GINS complex subunit 3
K10735 GINS4; GINS complex subunit 4
K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
K06628 CDC45; cell division control protein 45
K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
K10736 MCM10; minichromosome maintenance protein 10
K15254 HELB; DNA helicase B [EC:5.6.2.3]
K24274 FAM111A; protein FAM111A
K26052 CINP; cyclin-dependent kinase 2-interacting protein
K26116 MTBP; Mdm2-binding protein
K26117 TICRR; Treslin
K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
K02321 POLA2; DNA polymerase alpha subunit B
K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
K02685 PRI2; DNA primase large subunit
K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328 POLD2; DNA polymerase delta subunit 2
K03504 POLD3; DNA polymerase delta subunit 3
K03505 POLD4; DNA polymerase delta subunit 4
K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
K02333 POLG2; DNA polymerase gamma 2
K07466 RFA1; replication factor A1
K10739 RFA2; replication factor A2
K10740 RPA3; replication factor A3
K10741 RPA4; replication factor A4
K10754 RFC1; replication factor C subunit 1
K10755 RFC2_4; replication factor C subunit 2/4
K10755 RFC2_4; replication factor C subunit 2/4
K10756 RFC3_5; replication factor C subunit 3/5
K10756 RFC3_5; replication factor C subunit 3/5
K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
K10744 RNASEH2B; ribonuclease H2 subunit B
K10745 RNASEH2C; ribonuclease H2 subunit C
K04802 PCNA; proliferating cell nuclear antigen
K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
K26118 ATAD5; ATPase family AAA domain-containing protein 5
K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
K10749 GMNN; geminin
K26119 MCIDAS; multicilin
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K21771 CCNB3; G2/mitotic-specific cyclin-B3
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K11109 POT1; protection of telomeres protein 1
K11110 TERF1; telomeric repeat-binding factor 1
K11111 TERF2; telomeric repeat-binding factor 2
K11112 TINF2; TERF1-interacting nuclear factor 2
K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
K11114 ACD; adrenocortical dysplasia protein
K25749 TERB1; telomere repeats-binding bouquet formation protein 1
K25750 TERB2; telomere repeats-binding bouquet formation protein 2
K25751 MAJIN; membrane-anchored junction protein
K23311 CTC1; CST complex subunit CTC1
K23312 STN1; CST complex subunit STN1
K23313 TEN1; CST complex subunit TEN1
K11124 SMG6; protein SMG6 [EC:3.1.-.-]
K11125 SMG5; protein SMG5
K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
K11127 TEP1; telomerase protein component 1
K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
K11086 SNRPB; small nuclear ribonucleoprotein B and B'
K11087 SNRPD1; small nuclear ribonucleoprotein D1
K11096 SNRPD2; small nuclear ribonucleoprotein D2
K11088 SNRPD3; small nuclear ribonucleoprotein D3
K11097 SNRPE; small nuclear ribonucleoprotein E
K11098 SNRPF; small nuclear ribonucleoprotein F
K11099 SNRPG; small nuclear ribonucleoprotein G
K10865 MRE11; double-strand break repair protein MRE11
K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
K10867 NBN; nibrin
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10799 TNKS; tankyrase [EC:2.4.2.30]
K10799 TNKS; tankyrase [EC:2.4.2.30]
K11135 PINX1; Pin2-interacting protein X1
K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
K11137 TELO2; telomere length regulation protein
K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
K11138 RIF1; telomere-associated protein RIF1
K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
K21772 PURA; transcriptional activator protein Pur-alpha
K21800 PURG; purine-rich element-binding protein gamma
K23314 WRAP53; telomerase Cajal body protein 1
K25059 SDE2; replication stress response regulator SDE2
K25186 RTF2; replication termination factor 2
K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
K03111 ssb; single-strand DNA-binding protein
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03036 Chromosome and associated proteins [BR:hsa03036]
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03400 DNA repair and recombination proteins [BR:hsa03400]
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03029 Mitochondrial biogenesis [BR:hsa03029]
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09183 Protein families: signaling and cellular processes
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09185 Viral protein families
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09184 RNA family
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09190 Not Included in Pathway or Brite
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