Messenger RNA Biogenesis - Homo sapiens (human)

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     KO
 Eukaryotic type
   mRNA processing factors
   mRNA surveillance and transport factors
   mRNA degradation factors
     5'-3' decay
     3'-5' decay
       Core exosome factors
       Exosome cofactors
       TRAMP complex
       Ski complex
       Ccr4-NOT complex
       Pan complex
       Other 3'-5' decay factors
         5073 PARN; poly(A)-specific ribonuclease
         154197 PNLDC1; PARN like ribonuclease domain containing exonuclease 1
         170506 DHX36; DEAH-box helicase 36
         10140 TOB1; transducer of ERBB2, 1
         10766 TOB2; transducer of ERBB2, 2
         10950 BTG3; BTG anti-proliferation factor 3
         54766 BTG4; BTG anti-proliferation factor 4
         694 BTG1; BTG anti-proliferation factor 1
         7832 BTG2; BTG anti-proliferation factor 2
         1437 CSF2; colony stimulating factor 2
         25819 NOCT; nocturnin
         90459 ERI1; exoribonuclease 1
         112479 ERI2; ERI1 exoribonuclease family member 2
         28960 DCPS; decapping enzyme, scavenger
         201626 PDE12; phosphodiesterase 12
         3658 IREB2; iron responsive element binding protein 2
         9931 HELZ; helicase with zinc finger
         55051 NRDE2; NRDE-2, necessary for RNA interference, domain containing
         23034 SAMD4A; sterile alpha motif domain containing 4A
         55095 SAMD4B; sterile alpha motif domain containing 4B
K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4] 
K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4] 
K14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:3.6.4.13] 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K05427 CSF2; granulocyte-macrophage colony-stimulating factor 
K18764 NOCT; nocturnin [EC:3.1.3.108] 
K18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-] 
K18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-] 
K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59] 
K19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-] 
K22416 IREB2; iron-responsive element-binding protein 2 
K25168 HELZ; helicase with zinc finger domain [EC:3.6.4.-] 
K26109 NRDE2; nuclear exosome regulator NRDE2 
K27396 SMG; protein Smaug 
K27396 SMG; protein Smaug 
     Other degradation factors
 
 Prokaryotic type

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Last updated: April 9, 2024