Ubiquitin System - Homo sapiens (human)

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     KO
 Ubiquitins and ubiquitin-like proteins
 
 Ubiquitin-activating enzymes (E1)
 
 Ubiquitin-conjugating enzymes (E2)
 
 Ubiquitin ligases (E3)
   HECT type E3
   U-box type E3
   Single Ring-finger type E3
     BRE1 proteins
     CBL proteins
     SINA (Seven in absentia) proteins
     Ligand of Numb proteins
     March proteins
     MDM2/MDM4 proteins
     NFX1 proteins
     Pellino proteins
     Peripheral membrane proteins
     RBR proteins
     TRAF proteins
     TRIM/RBCC proteins
     UBR box proteins
     ATL proteins
     Other single Ring-finger type E3
       267 AMFR; autocrine motility factor receptor
       326 AIRE; autoimmune regulator
       51283 BFAR; bifunctional apoptosis regulator
       329 BIRC2; baculoviral IAP repeat containing 2
       330 BIRC3; baculoviral IAP repeat containing 3
       331 XIAP; X-linked inhibitor of apoptosis
       79444 BIRC7; baculoviral IAP repeat containing 7
       8315 BRAP; BRCA1 associated protein
       672 BRCA1; BRCA1 DNA repair associated
       79872 CBLL1; Cbl proto-oncogene like 1
       57820 CCNB1IP1; cyclin B1 interacting protein 1
       55743 CHFR; checkpoint with forkhead and ring finger domains
       4850 CNOT4; CCR4-NOT transcription complex subunit 4
       149095 DCST1; DC-STAMP domain containing 1
       113878 DTX2; deltex E3 ubiquitin ligase 2
       151636 DTX3L; deltex E3 ubiquitin ligase 3L
       1840 DTX1; deltex E3 ubiquitin ligase 1
       196403 DTX3; deltex E3 ubiquitin ligase 3
       23220 DTX4; deltex E3 ubiquitin ligase 4
       9666 DZIP3; DAZ interacting zinc finger protein 3
       55120 FANCL; FA complementation group L
       56888 KCMF1; potassium channel modulatory factor 1
       90678 LRSAM1; leucine rich repeat and sterile alpha motif containing 1
       26046 LTN1; listerin E3 ubiquitin protein ligase 1
       4214 MAP3K1; mitogen-activated protein kinase kinase kinase 1
       399664 MEX3D; mex-3 RNA binding family member D
       51320 MEX3C; mex-3 RNA binding family member C
       84206 MEX3B; mex-3 RNA binding family member B
       92312 MEX3A; mex-3 RNA binding family member A
       23295 MGRN1; mahogunin ring finger 1
       57534 MIB1; mindbomb E3 ubiquitin protein ligase 1
       142678 MIB2; mindbomb E3 ubiquitin protein ligase 2
       23608 MKRN1; makorin ring finger protein 1
       23609 MKRN2; makorin ring finger protein 2
       7681 MKRN3; makorin ring finger protein 3
       79594 MUL1; mitochondrial E3 ubiquitin protein ligase 1
       23077 MYCBP2; MYC binding protein 2
       29116 MYLIP; myosin regulatory light chain interacting protein
       54492 NEURL1B; neuralized E3 ubiquitin protein ligase 1B
       9148 NEURL1; neuralized E3 ubiquitin protein ligase 1
       93082 NEURL3; neuralized E3 ubiquitin protein ligase 3
       378884 NHLRC1; NHL repeat containing E3 ubiquitin protein ligase 1
       79596 OBI1; ORC ubiquitin ligase 1
       64219 PJA1; praja ring finger ubiquitin ligase 1
       9867 PJA2; praja ring finger ubiquitin ligase 2
       56852 RAD18; RAD18 E3 ubiquitin protein ligase
       5896 RAG1; recombination activating 1
       25898 RCHY1; ring finger and CHY zinc finger domain containing 1
       149041 RC3H1; ring finger and CCCH-type domains 1
       54542 RC3H2; ring finger and CCCH-type domains 2
       64326 COP1; COP1 E3 ubiquitin ligase
       55159 RFWD3; ring finger and WD repeat domain 3
       6045 RNF2; ring finger protein 2
       6015 RING1; ring finger protein 1
       6047 RNF4; ring finger protein 4
       6048 RNF5; ring finger protein 5
       91445 RNF185; ring finger protein 185
       6049 RNF6; ring finger protein 6
       9025 RNF8; ring finger protein 8
       26994 RNF11; ring finger protein 11
       51132 RLIM; ring finger protein, LIM domain interacting
       11342 RNF13; ring finger protein 13
       64320 RNF25; ring finger protein 25
       79102 RNF26; ring finger protein 26
       152006 RNF38; ring finger protein 38
       22838 RNF44; ring finger protein 44
       10193 RNF41; ring finger protein 41
       54894 RNF43; ring finger protein 43
       7844 RNF103; ring finger protein 103
       54778 RNF111; ring finger protein 111
       140432 RNF113B; ring finger protein 113B
       55905 RNF114; ring finger protein 114
       27246 RNF115; ring finger protein 115
       55658 RNF126; ring finger protein 126
       55298 RNF121; ring finger protein 121
       285533 RNF175; ring finger protein 175
       79845 RNF122; ring finger protein 122
       63891 RNF123; ring finger protein 123
       54941 RNF125; ring finger protein 125
       79589 RNF128; ring finger protein 128
       55819 RNF130; ring finger protein 130
       168433 RNF133; ring finger protein 133
       84282 RNF135; ring finger protein 135
       51444 RNF138; ring finger protein 138
       11236 RNF139; ring finger protein 139
       153830 RNF145; ring finger protein 145
       81847 RNF146; ring finger protein 146
       284996 RNF149; ring finger protein 149
       220441 RNF152; ring finger protein 152
       494470 RNF165; ring finger protein 165
       115992 RNF166; ring finger protein 166
       26001 RNF167; ring finger protein 167
       81790 RNF170; ring finger protein 170
       285671 RNF180; ring finger protein 180
       51255 RNF181; ring finger protein 181
       221687 RNF182; ring finger protein 182
       149603 RNF187; ring finger protein 187
       57674 RNF213; ring finger protein 213
       51136 RNFT1; ring finger protein, transmembrane 1
       9092 SART1; spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
       257218 SHPRH; SNF2 histone linker PHD RING helicase
       57630 SH3RF1; SH3 domain containing ring finger 1
       153769 SH3RF2; SH3 domain containing ring finger 2
       344558 SH3RF3; SH3 domain containing ring finger 3
       6596 HLTF; helicase like transcription factor
       84447 SYVN1; synoviolin 1
       92305 TMEM129; transmembrane protein 129, E3 ubiquitin ligase
       10210 TOPORS; TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
       10293 TRAIP; TRAF interacting protein
       7267 TTC3; tetratricopeptide repeat domain 3
       29128 UHRF1; ubiquitin like with PHD and ring finger domains 1
       115426 UHRF2; ubiquitin like with PHD and ring finger domains 2
       64718 UNKL; unk like zinc finger
       90850 ZNF598; zinc finger protein 598, E3 ubiquitin ligase
       158506 CBLL2; Cbl proto-oncogene like 2
       84937 ZNRF1; zinc and ring finger 1
       223082 ZNRF2; zinc and ring finger 2
       84133 ZNRF3; zinc and ring finger 3
       148066 ZNRF4; zinc and ring finger 4
       151112 ZSWIM2; zinc finger SWIM-type containing 2
K10636 AMFR; autocrine motility factor receptor [EC:2.3.2.27] 
K10603 AIRE; autoimmune regulator 
K15684 BFAR; bifunctional apoptosis regulator 
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3 
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3 
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27] 
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8 
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27] 
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27] 
K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27] 
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27] 
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27] 
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K06058 DTX; deltex [EC:2.3.2.27] 
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27] 
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27] 
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27] 
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27] 
K04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27] 
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27] 
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27] 
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27] 
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33] 
K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27] 
K01931 NEUR; protein neuralized [EC:2.3.2.27] 
K01931 NEUR; protein neuralized [EC:2.3.2.27] 
K15689 NEURL3; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27] 
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27] 
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27] 
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27] 
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27] 
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27] 
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27] 
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein 
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein 
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27] 
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27] 
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27] 
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27] 
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27] 
K10666 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27] 
K10666 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27] 
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27] 
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
K11980 RNF11; E3 ubiquitin-protein ligase RNF11 
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27] 
K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27] 
K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27] 
K15693 RNF26; RING finger protein 26 
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27] 
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27] 
K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27] 
K15694 RNF43; RING finger protein 43 [EC:2.3.2.27] 
K15695 RNF103; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27] 
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27] 
K15696 RNF113B; RING finger protein 113B 
K15697 RNF114; RING finger protein 114 [EC:2.3.2.27] 
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27] 
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27] 
K15698 RNF121_175; RING finger protein 121/175 
K15698 RNF121_175; RING finger protein 121/175 
K15699 RNF122; RING finger protein 122 
K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27] 
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27] 
K10629 RNF128; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27] 
K15701 RNF130; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27] 
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27] 
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27] 
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27] 
K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27] 
K23789 RNF145; RING finger protein 145 [EC:2.3.2.27] 
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27] 
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27] 
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27] 
K17821 RNF165; RING finger protein 165 
K17044 RNF166; RING finger protein 166 
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27] 
K15707 RNF170; RING finger protein 170 [EC:2.3.2.27] 
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27] 
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27] 
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27] 
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27] 
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27] 
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27] 
K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1 
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:3.6.4.- 2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27] 
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:3.6.4.- 2.3.2.27] 
K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27] 
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27] 
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27] 
K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27] 
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27] 
K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27] 
K15713 UHRF2; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27] 
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27] 
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27] 
K15714 ZNF645; E3 ubiquitin-protein ligase ZNF645 [EC:2.3.2.27] 
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27] 
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27] 
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27] 
K15715 ZNRF4; Zinc/RING finger protein 4 
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27] 
   Atypical E3
   UBL E3 ligases
   Multi subunit Ring-finger type E3
     SCF complex
     ECV complex
     Cul3 complex
     Cul4 complex
     ECS complex
     Cul7 complex
     Cul9 complex
     APC/C
     BRCC complex
       672 BRCA1; BRCA1 DNA repair associated
       675 BRCA2; BRCA2 DNA repair associated
       79184 BRCC3; BRCA1/BRCA2-containing complex subunit 3
       580 BARD1; BRCA1 associated RING domain 1
       9577 BABAM2; BRISC and BRCA1 A complex member 2
       5888 RAD51; RAD51 recombinase
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
K08775 BRCA2; breast cancer 2 susceptibility protein 
K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
K10683 BARD1; BRCA1-associated RING domain protein 1 
K12173 BRE; BRCA1-A complex subunit BRE 
K04482 RAD51; DNA repair protein RAD51 
     KPC complex
     LUBAC complex
     CTLH complex
     ERAD complex
     SLX5-SLX8 complex
     Multi subunit type E3 associated proteins
 
 Deubiquitinating enzyme (DUB)

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Last updated: May 13, 2020