 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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02020 Two-component system [PATH:ko02020]
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04010 MAPK signaling pathway [PATH:ko04010]
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04013 MAPK signaling pathway - fly [PATH:ko04013]
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04016 MAPK signaling pathway - plant [PATH:ko04016]
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04011 MAPK signaling pathway - yeast [PATH:ko04011]
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04012 ErbB signaling pathway [PATH:ko04012]
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04014 Ras signaling pathway [PATH:ko04014]
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04015 Rap1 signaling pathway [PATH:ko04015]
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04310 Wnt signaling pathway [PATH:ko04310]
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04330 Notch signaling pathway [PATH:ko04330]
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04340 Hedgehog signaling pathway [PATH:ko04340]
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04341 Hedgehog signaling pathway - fly [PATH:ko04341]
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04350 TGF-beta signaling pathway [PATH:ko04350]
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04390 Hippo signaling pathway [PATH:ko04390]
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04391 Hippo signaling pathway - fly [PATH:ko04391]
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04392 Hippo signaling pathway - multiple species [PATH:ko04392]
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04370 VEGF signaling pathway [PATH:ko04370]
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04371 Apelin signaling pathway [PATH:ko04371]
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04630 JAK-STAT signaling pathway [PATH:ko04630]
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04064 NF-kappa B signaling pathway [PATH:ko04064]
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04668 TNF signaling pathway [PATH:ko04668]
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04066 HIF-1 signaling pathway [PATH:ko04066]
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04068 FoxO signaling pathway [PATH:ko04068]
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 K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04501 SMAD4; mothers against decapentaplegic homolog 4
K23605 SMAD3; mothers against decapentaplegic homolog 3
K07298 STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07198 PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K04468 NLK; nemo like kinase [EC:2.7.11.24]
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K11431 SETD7; [histone H3]-lysine4 N-methyltransferase [EC:2.1.1.364]
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K11411 SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11838 USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
K07191 SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04411 STK4, MST1; serine/threonine kinase 4
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04526 INS; insulin
K04527 INSR, CD220; insulin receptor [EC:2.7.10.1]
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2; insulin receptor substrate 2
K17445 IRS3; insulin receptor substrate 3
K17446 IRS4; insulin receptor substrate 4
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
K13303 SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
K13304 SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
K07201 FOXO1; forkhead box protein O1
K09408 FOXO3; forkhead box protein O3
K12358 FOXO4; forkhead box protein O4
K17847 FOXO6; forkhead box protein O6
K04603 GRM1; metabotropic glutamate receptor 1
K15010 HOMER; homer
K17848 AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
K08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K05405 IL6; interleukin 6
K05443 IL10, CSIF; interleukin 10
K04692 STAT3; signal transducer and activator of transcription 3
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K11434 PRMT1; type I protein arginine methyltransferase [EC:2.1.1.319]
K09385 FOXG; forkhead box protein G
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K21771 CCNB3; G2/mitotic-specific cyclin-B3
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10146 CCNG2; cyclin G2
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K06623 CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K16332 RBL2; retinoblastoma-like protein 2
K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
K08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]
K08862 PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
K08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04389 TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K16341 BCL2L11, BIM; Bcl-2-like protein 11
K04721 TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
K15618 BCL6; B-cell lymphoma 6 protein
K15464 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
K08336 ATG12; ubiquitin-like protein ATG12
K08341 GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
K03781 katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K04728 ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
K01596 E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K05072 IL7R, CD127; interleukin 7 receptor
K17845 KLF2; krueppel-like factor 2
K04288 S1PR1, EDG1, CD363; sphingosine 1-phosphate receptor 1
K04293 S1PR4, EDG6; sphingosine 1-phosphate receptor 4
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10988 RAG2; recombination-activating protein 2
K10305 FBXO25_32; F-box protein 25/32
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04020 Calcium signaling pathway [PATH:ko04020]
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04070 Phosphatidylinositol signaling system [PATH:ko04070]
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04072 Phospholipase D signaling pathway [PATH:ko04072]
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04071 Sphingolipid signaling pathway [PATH:ko04071]
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04024 cAMP signaling pathway [PATH:ko04024]
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04022 cGMP-PKG signaling pathway [PATH:ko04022]
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04151 PI3K-Akt signaling pathway [PATH:ko04151]
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04152 AMPK signaling pathway [PATH:ko04152]
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04150 mTOR signaling pathway [PATH:ko04150]
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04075 Plant hormone signal transduction [PATH:ko04075]
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09141 Transport and catabolism
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09143 Cell growth and death
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04110 Cell cycle [PATH:ko04110]
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K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K04681 RBL1; retinoblastoma-like protein 1
K16332 RBL2; retinoblastoma-like protein 2
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04682 E2F4_5; transcription factor E2F4/5
K04683 TFDP1; transcription factor Dp-1
K09392 TFDP2; transcription factor Dp-2
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04377 MYC; Myc proto-oncogene protein
K10500 ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K06622 CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
K06623 CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K09993 CDKN1C, P57, KIP2; cyclin-dependent kinase inhibitor 1C
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
K03347 CUL1, CDC53; cullin 1
K03868 RBX1, ROC1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06627 CCNA; cyclin-A
K02213 CDC6; cell division control protein 6
K10727 CDT1; chromatin licensing and DNA replication factor 1
K02603 ORC1; origin recognition complex subunit 1
K02604 ORC2; origin recognition complex subunit 2
K02605 ORC3; origin recognition complex subunit 3
K02606 ORC4; origin recognition complex subunit 4
K02607 ORC5; origin recognition complex subunit 5
K02608 ORC6; origin recognition complex subunit 6
K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
K02212 MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3]
K02209 MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3]
K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
K02210 MCM7, CDC47; DNA replication licensing factor MCM7 [EC:5.6.2.3]
K06628 CDC45; cell division control protein 45
K26117 TICRR; Treslin
K26116 MTBP; Mdm2-binding protein
K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
K06629 DBF4, ASK; protein DBF4
K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K21771 CCNB3; G2/mitotic-specific cyclin-B3
K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
K06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
K06634 CCNH; cyclin H
K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
K03348 APC1, ANAPC1; anaphase-promoting complex subunit 1
K03349 APC2, ANAPC2; anaphase-promoting complex subunit 2
K03350 APC3, CDC27; anaphase-promoting complex subunit 3
K03351 APC4, ANAPC4; anaphase-promoting complex subunit 4
K03352 APC5, ANAPC5; anaphase-promoting complex subunit 5
K03353 APC6, CDC16; anaphase-promoting complex subunit 6
K03354 APC7, ANAPC7; anaphase-promoting complex subunit 7
K03355 APC8, CDC23; anaphase-promoting complex subunit 8
K03357 APC10, ANAPC10, DOC1; anaphase-promoting complex subunit 10
K03358 APC11, ANAPC11; anaphase-promoting complex subunit 11
K03359 APC12, CDC26; anaphase-promoting complex subunit 12
K12456 APC13, ANAPC13; anaphase-promoting complex subunit 13
K25228 APC15, ANAPC15; anaphase-promoting complex subunit 15
K25229 APC16, ANAPC16; anaphase-promoting complex subunit 16
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K06635 PTTG; securin
K02365 ESP1; separase [EC:3.4.22.49]
K06636 SMC1; structural maintenance of chromosome 1
K06669 SMC3, CSPG6; structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K06670 SCC1, MCD1, RAD21; cohesin complex subunit SCC1
K06671 STAG1_2, SCC3, IRR1; cohesin complex subunit SA-1/2
K10779 ATRX; transcriptional regulator ATRX
K11273 DDX11, CHL1, CTF1; chromosome transmission fidelity protein 1 [EC:3.6.4.13]
K06672 SCC2, NIPBL; cohesin loading factor subunit SCC2
K11266 MAU2; MAternally affected uncoordination
K11405 HDAC8; histone deacetylase 8 [EC:3.5.1.98]
K11268 ESCO, ECO1; N-acetyltransferase [EC:2.3.1.-]
K11267 PDS5; sister chromatid cohesion protein PDS5
K25163 WAPL; wings apart-like protein
K17390 CDCA5; sororin
K11479 AURKB; aurora kinase B [EC:2.7.11.1]
K11580 SGOL1; shugoshin-like 1
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11547 NDC80, HEC1, TID3; kinetochore protein NDC80
K11542 CASC5, KNL1; protein CASC5
K08866 TTK, MPS1; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]
K06679 MAD1; mitotic spindle assembly checkpoint protein MAD1
K02537 MAD2; mitotic spindle assembly checkpoint protein MAD2
K13728 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
K06637 BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
K02180 BUB3; cell cycle arrest protein BUB3
K02178 BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]
K22399 TRIP13; pachytene checkpoint protein 2
K26093 MAD2L1BP; MAD2L1-binding protein
K03364 CDH1, FZR1; cell division cycle 20-like protein 1, cofactor of APC complex
K10292 FBXO5, EMI1; F-box protein 5
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K04728 ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53, P53; tumor protein p53
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04802 PCNA; proliferating cell nuclear antigen
K06644 SFN; stratifin
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
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04111 Cell cycle - yeast [PATH:ko04111]
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04112 Cell cycle - Caulobacter [PATH:ko04112]
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04113 Meiosis - yeast [PATH:ko04113]
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04114 Oocyte meiosis [PATH:ko04114]
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04210 Apoptosis [PATH:ko04210]
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04214 Apoptosis - fly [PATH:ko04214]
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04215 Apoptosis - multiple species [PATH:ko04215]
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04216 Ferroptosis [PATH:ko04216]
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04217 Necroptosis [PATH:ko04217]
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04115 p53 signaling pathway [PATH:ko04115]
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04218 Cellular senescence [PATH:ko04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO)