1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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4. Lyases
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5. Isomerases
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5.1 Racemases and epimerases
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5.2 cis-trans-Isomerases
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5.3 Intramolecular oxidoreductases
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5.4 Intramolecular transferases
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5.5 Intramolecular lyases
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5.6 Isomerases altering macromolecular conformation
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5.6.1 Enzymes altering polypeptide conformation or assembly
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5.6.2 Enzymes altering nucleic acid conformation
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5.6.2.1 DNA topoisomerase
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5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
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5.6.2.3 DNA 5'-3' helicase
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K02209 MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3]
K02210 MCM7, CDC47; DNA replication licensing factor MCM7 [EC:5.6.2.3]
K02212 MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3]
K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3]
K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
K10844 ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
K11338 RUVBL2, RVB2, INO80J; RuvB-like protein 2 [EC:5.6.2.3]
K14326 UPF1, RENT1; regulator of nonsense transcripts 1 [EC:3.6.4.13 5.6.2.3]
K15254 HELB; DNA helicase B [EC:5.6.2.3]
K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
K15362 BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]
K17265 G3BP1; Ras GTPase-activating protein-binding protein 1 [EC:5.6.2.3 3.6.4.13]
K17680 PEO1; twinkle protein [EC:5.6.2.3]
K18947 gp41; Straboviridae DNA replication helicase [EC:5.6.2.3]
K19036 IGHMBP2; ATP-dependent RNA/DNA helicase IGHMBP2 [EC:3.6.4.13 5.6.2.3]
K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
K21499 dda; Straboviridae ATP-dependent DNA helicase [EC:5.6.2.3]
K21502 gp4; Autographiviridae DNA primase/helicase [EC:2.7.7.- 5.6.2.3]
K25022 nsp13; SARS coronavirus helicase [EC:5.6.2.3 3.6.4.13]
K25237 UL5, HELI; Simplexvirus DNA replication helicase [EC:5.6.2.3]
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5.6.2.4 DNA 3'-5' helicase
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5.6.2.5 RNA 5'-3' helicase
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5.6.2.6 RNA 3'-5' helicase
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5.6.2.7 DEAD-box RNA helicase
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5.99 Other isomerases
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6. Ligases
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7. Translocases
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