 1. Oxidoreductases
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2. Transferases
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 3. Hydrolases
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3.1 Acting on ester bonds
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3.1.1 Carboxylic-ester hydrolases
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3.1.2 Thioester hydrolases
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3.1.3 Phosphoric-monoester hydrolases
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3.1.3.1 alkaline phosphatase
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3.1.3.2 acid phosphatase
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3.1.3.3 phosphoserine phosphatase
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3.1.3.4 phosphatidate phosphatase
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3.1.3.5 5'-nucleotidase
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3.1.3.6 3'-nucleotidase
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3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
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3.1.3.8 3-phytase
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3.1.3.9 glucose-6-phosphatase
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3.1.3.10 glucose-1-phosphatase
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3.1.3.11 fructose-bisphosphatase
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3.1.3.12 trehalose-phosphatase
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 3.1.3.14 methylphosphothioglycerate phosphatase
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3.1.3.15 histidinol-phosphatase
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3.1.3.16 protein-serine/threonine phosphatase
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K01090 E3.1.3.16; protein phosphatase [EC:3.1.3.16]
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04348 PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04457 PPM1A, PP2CA; protein phosphatase 1A [EC:3.1.3.16]
K04459 DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
K04460 PPP5C; serine/threonine-protein phosphatase 5 [EC:3.1.3.16]
K04461 PPM1B, PP2CB; protein phosphatase 1B [EC:3.1.3.16]
K05766 SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K06382 spoIIE; stage II sporulation protein E [EC:3.1.3.16]
K06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]
K07313 pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]
K07314 pphB; serine/threonine protein phosphatase 2 [EC:3.1.3.16]
K10147 PPM1D, WIP1; protein phosphatase 1D [EC:3.1.3.16]
K11915 stp1, pppA; serine/threonine protein phosphatase Stp1 [EC:3.1.3.16]
K13807 PPEF, PPP7C; serine/threonine-protein phosphatase with EF-hands [EC:3.1.3.16]
K14165 K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]
K14167 CDKN3, KAP; cyclin-dependent kinase inhibitor 3 [EC:3.1.3.16 3.1.3.48]
K14497 PP2C; protein phosphatase 2C [EC:3.1.3.16]
K14501 BSU1; serine/threonine-protein phosphatase BSU1 [EC:3.1.3.16]
K14803 PTC2_3; protein phosphatase PTC2/3 [EC:3.1.3.16]
K14819 DUSP12, YVH1; dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]
K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
K15427 SIT4, PPH1; serine/threonine-protein phosphatase PP1-1 [EC:3.1.3.16]
K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
K15637 PGAM5; serine/threonine-protein phosphatase PGAM5 [EC:3.1.3.16]
K15731 CTDSP; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase [EC:3.1.3.16]
K15732 CTDP1, FCP1; RNA polymerase II subunit A C-terminal domain phosphatase [EC:3.1.3.16]
K16340 PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
K17499 PPM1G, PP2CG; protein phosphatase 1G [EC:3.1.3.16]
K17500 ILKAP; integrin-linked kinase-associated serine/threonine phosphatase 2C [EC:3.1.3.16]
K17501 PPM1E, POPX1; protein phosphatase 1E [EC:3.1.3.16]
K17502 PPM1F, POPX2; protein phosphatase 1F [EC:3.1.3.16]
K17503 PPM1H, ARHCL1; protein phosphatase 1H [EC:3.1.3.16]
K17504 PPM1J, PP2CZ; protein phosphatase 1J [EC:3.1.3.16]
K17505 PPM1K, PP2CM; protein phosphatase 1K [EC:3.1.3.16]
K17506 PPM1L, PP2CE; protein phosphatase 1L [EC:3.1.3.16]
K17507 PPM1M, PP2CE; protein phosphatase 1M [EC:3.1.3.16]
K17508 PTC7, PPTC7; protein phosphatase PTC7 [EC:3.1.3.16]
K17614 DUSP3, VHR; dual specificity phosphatase 3 [EC:3.1.3.16 3.1.3.48]
K17615 PPG1; serine/threonine-protein phosphatase PPG1 [EC:3.1.3.16]
K17617 CTDNEP1, DULLARD, NEM1; CTD nuclear envelope phosphatase 1 [EC:3.1.3.16]
K17618 UBLCP1; ubiquitin-like domain-containing CTD phosphatase 1 [EC:3.1.3.16]
K18498 DUSP9, MKP4; dual specificity phosphatase 9 [EC:3.1.3.16 3.1.3.48]
K18998 CPL1_2; RNA polymerase II C-terminal domain phosphatase-like 1/2 [EC:3.1.3.16]
K18999 CPL3_4; RNA polymerase II C-terminal domain phosphatase-like 3/4 [EC:3.1.3.16]
K19704 PTC1; protein phosphatase PTC1 [EC:3.1.3.16]
K19705 PTC4; protein phosphatase PTC4 [EC:3.1.3.16]
K19708 PTC6, AUP1; protein phosphatase PTC6 [EC:3.1.3.16 3.1.3.43]
K19790 PPM1N; protein phosphatase 1N [EC:3.1.3.16]
K20074 prpC, phpP; PPM family protein phosphatase [EC:3.1.3.16]
K20216 DUSP10; dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]
K20551 MKP2; dual specificity protein phosphatase 1B [EC:3.1.3.16 3.1.3.48]
K20827 RPAP2; RNA polymerase II-associated protein 2 [EC:3.1.3.16]
K21278 DUSP1; dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
K21814 CPPED1; serine/threonine-protein phosphatase CPPED1 [EC:3.1.3.16]
K21946 DUSP6; dual specificity phosphatase 6 [EC:3.1.3.16 3.1.3.48]
K23534 PP2CHN; protein phosphatase [EC:3.1.3.16]
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3.1.3.17 [phosphorylase] phosphatase
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3.1.3.18 phosphoglycolate phosphatase
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3.1.3.19 glycerol-2-phosphatase
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3.1.3.20 phosphoglycerate phosphatase
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3.1.3.21 glycerol-1-phosphatase
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3.1.3.22 mannitol-1-phosphatase
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3.1.3.23 sugar-phosphatase
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3.1.3.24 sucrose-phosphate phosphatase
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3.1.3.25 inositol-phosphate phosphatase
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3.1.3.26 4-phytase
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3.1.3.27 phosphatidylglycerophosphatase
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3.1.3.28 ADP-phosphoglycerate phosphatase
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3.1.3.29 N-acylneuraminate-9-phosphatase
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3.1.3.32 polynucleotide 3'-phosphatase
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3.1.3.33 polynucleotide 5'-phosphatase
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3.1.3.34 deoxynucleotide 3'-phosphatase
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3.1.3.35 thymidylate 5'-phosphatase
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3.1.3.36 phosphoinositide 5-phosphatase
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3.1.3.37 sedoheptulose-bisphosphatase
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3.1.3.38 3-phosphoglycerate phosphatase
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3.1.3.39 streptomycin-6-phosphatase
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3.1.3.40 guanidinodeoxy-scyllo-inositol-4-phosphatase
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3.1.3.41 4-nitrophenylphosphatase
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3.1.3.42 [glycogen-synthase-D] phosphatase
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3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
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3.1.3.44 [acetyl-CoA carboxylase]-phosphatase
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3.1.3.45 3-deoxy-manno-octulosonate-8-phosphatase
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3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase
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3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
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3.1.3.48 protein-tyrosine-phosphatase
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3.1.3.49 [pyruvate kinase]-phosphatase
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3.1.3.50 sorbitol-6-phosphatase
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3.1.3.51 dolichyl-phosphatase
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3.1.3.52 [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase
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3.1.3.53 [myosin-light-chain] phosphatase
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3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase
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3.1.3.55 caldesmon-phosphatase
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3.1.3.56 inositol-polyphosphate 5-phosphatase
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3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
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3.1.3.58 sugar-terminal-phosphatase
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3.1.3.59 alkylacetylglycerophosphatase
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3.1.3.60 phosphoenolpyruvate phosphatase
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3.1.3.62 multiple inositol-polyphosphate phosphatase
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3.1.3.63 2-carboxy-D-arabinitol-1-phosphatase
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3.1.3.64 phosphatidylinositol-3-phosphatase
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3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
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3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
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3.1.3.68 2-deoxyglucose-6-phosphatase
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3.1.3.69 glucosylglycerol 3-phosphatase
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3.1.3.70 mannosyl-3-phosphoglycerate phosphatase
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3.1.3.71 2-phosphosulfolactate phosphatase
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3.1.3.72 5-phytase
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3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
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3.1.3.74 pyridoxal phosphatase
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3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
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3.1.3.76 lipid-phosphate phosphatase
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3.1.3.77 acireductone synthase
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3.1.3.78 phosphatidylinositol-4,5-bisphosphate 4-phosphatase
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3.1.3.79 mannosylfructose-phosphate phosphatase
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3.1.3.80 2,3-bisphosphoglycerate 3-phosphatase
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3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase
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3.1.3.83 D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphatase
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3.1.3.84 ADP-ribose 1''-phosphate phosphatase
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3.1.3.85 glucosyl-3-phosphoglycerate phosphatase
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3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
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3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
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3.1.3.88 5''-phosphoribostamycin phosphatase
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3.1.3.89 5'-deoxynucleotidase
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3.1.3.90 maltose 6'-phosphate phosphatase
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3.1.3.91 7-methylguanosine nucleotidase
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3.1.3.92 kanosamine-6-phosphate phosphatase
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3.1.3.93 L-galactose 1-phosphate phosphatase
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3.1.3.94 D-galactose 1-phosphate phosphatase
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3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase
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3.1.3.96 pseudouridine 5'-phosphatase
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3.1.3.97 3',5'-nucleoside bisphosphate phosphatase
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3.1.3.99 IMP-specific 5'-nucleotidase
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3.1.3.100 thiamine phosphate phosphatase
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3.1.3.101 validoxylamine A 7'-phosphate phosphatase
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3.1.3.102 FMN hydrolase
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3.1.3.103 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase
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3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
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3.1.3.105 N-acetyl-D-muramate 6-phosphate phosphatase
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3.1.3.106 2-lysophosphatidate phosphatase
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3.1.3.107 amicoumacin phosphatase
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3.1.3.108 nocturnin
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3.1.3.109 ribulose-1,5-bisphosphate 5-phosphatase
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3.1.3.110 4'-phosphopantetheine phosphatase
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3.1.4 Phosphoric-diester hydrolases
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3.1.5 Triphosphoric-monoester hydrolases
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3.1.6 Sulfuric-ester hydrolases
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3.1.7 Diphosphoric-monoester hydrolases
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3.1.8 Phosphoric-triester hydrolases
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3.1.11 Exodeoxyribonucleases producing 5'-phosphomonoesters
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3.1.12 Exodeoxyribonucleases producing 3'-phosphomonoesters
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3.1.13 Exoribonucleases producing 5'-phosphomonoesters
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3.1.14 Exoribonucleases producing 3'-phosphomonoesters
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3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
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3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
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3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
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3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
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3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
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3.1.26 Endoribonucleases producing 5'-phosphomonoesters
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3.1.27 Endoribonucleases producing 3'-phosphomonoesters
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3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
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3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
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3.2 Glycosylases
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3.3 Acting on ether bonds
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3.4 Acting on peptide bonds (peptidases)
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3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
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3.6 Acting on acid anhydrides
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3.7 Acting on carbon-carbon bonds
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3.8 Acting on halide bonds
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3.9 Acting on phosphorus-nitrogen bonds
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3.10 Acting on sulfur-nitrogen bonds
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3.11 Acting on carbon-phosphorus bonds
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3.12 Acting on sulfur-sulfur bonds
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3.13 Acting on carbon-sulfur bonds
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4. Lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes