 1. Oxidoreductases
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2. Transferases
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 3. Hydrolases
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3.1 Acting on ester bonds
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3.2 Glycosylases
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3.3 Acting on ether bonds
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3.4 Acting on peptide bonds (peptidases)
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3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
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3.5.1 In linear amides
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3.5.2 In cyclic amides
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3.5.2.1 barbiturase
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3.5.2.2 dihydropyrimidinase
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3.5.2.3 dihydroorotase
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 3.5.2.4 carboxymethylhydantoinase
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3.5.2.5 allantoinase
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3.5.2.6 beta-lactamase
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K01467 ampC; beta-lactamase class C [EC:3.5.2.6]
K17836 penP; beta-lactamase class A [EC:3.5.2.6]
K17837 bla2, blm, ccrA, blaB; metallo-beta-lactamase class B [EC:3.5.2.6]
K17838 oxa; beta-lactamase class D [EC:3.5.2.6]
K18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]
K18699 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6]
K18766 blaZ; beta-lactamase class A BlaZ [EC:3.5.2.6]
K18767 blaCTX-M; beta-lactamase class A CTX-M [EC:3.5.2.6]
K18768 blaKPC; beta-lactamase class A KPC [EC:3.5.2.6]
K18780 blaNDM; metallo-beta-lactamase class B NDM [EC:3.5.2.6]
K18781 blaVIM; metallo-beta-lactamase class B VIM [EC:3.5.2.6]
K18782 blaIMP; metallo-beta-lactamase class B IMP [EC:3.5.2.6]
K18790 blaOXA-1; beta-lactamase class D OXA-1 [EC:3.5.2.6]
K18791 blaOXA-2; beta-lactamase class D OXA-2 [EC:3.5.2.6]
K18792 blaOXA-10; beta-lactamase class D OXA-10 [EC:3.5.2.6]
K18793 blaOXA-23; beta-lactamase class D OXA-23 [EC:3.5.2.6]
K18794 blaOXA-51; beta-lactamase class D OXA-51 [EC:3.5.2.6]
K18795 blaCARB-1; beta-lactamase class A CARB-1, PSE family [EC:3.5.2.6]
K18796 blaLEN; beta-lactamase class A LEN [EC:3.5.2.6]
K18797 blaPER; beta-lactamase class A PER [EC:3.5.2.6]
K18970 blaGES; beta-lactamase class A GES [EC:3.5.2.6]
K18971 blaOXA-24; beta-lactamase class D OXA-24 [EC:3.5.2.6]
K18972 blaOXA-58; beta-lactamase class D OXA-58 [EC:3.5.2.6]
K18973 blaOXA-50; beta-lactamase class D OXA-50 [EC:3.5.2.6]
K18976 blaOXA-48; beta-lactamase class D OXA-48 [EC:3.5.2.6]
K19095 blaCMY-1; beta-lactamase class C CMY-1 [EC:3.5.2.6]
K19096 blaCMY-2; beta-lactamase class C CMY-2 [EC:3.5.2.6]
K19097 blaVEB; beta-lactamase class A VEB [EC:3.5.2.6]
K19098 blaOXA-9; beta-lactamase class D OXA-9 [EC:3.5.2.6]
K19099 blaGIM; metallo-beta-lactamase class B GIM [EC:3.5.2.6]
K19100 blaDHA; beta-lactamase class C DHA [EC:3.5.2.6]
K19101 blaFOX; beta-lactamase class C FOX [EC:3.5.2.6]
K19209 blaOXA-42; beta-lactamase class D OXA-42 [EC:3.5.2.6]
K19210 blaOXA-61; beta-lactamase class D OXA-61 [EC:3.5.2.6]
K19211 blaOXA-62; beta-lactamase class D OXA-62 [EC:3.5.2.6]
K19212 blaOXA-63; beta-lactamase class D OXA-63 [EC:3.5.2.6]
K19213 blaOXA-12; beta-lactamase class D OXA-12 [EC:3.5.2.6]
K19214 blaACC; beta-lactamase class C ACC [EC:3.5.2.6]
K19215 blaACT_MIR; beta-lactamase class C ACT/MIR [EC:3.5.2.6]
K19216 blaIND; metallo-beta-lactamase class B IND [EC:3.5.2.6]
K19217 blaCARB-17; beta-lactamase class A CARB-17 [EC:3.5.2.6]
K19218 blaCARB-5; beta-lactamase class A CARB-5, RTG family [EC:3.5.2.6]
K19316 blaIMI; beta-lactamase class A IMI [EC:3.5.2.6]
K19317 blaBEL; beta-lactamase class A BEL [EC:3.5.2.6]
K19318 blaOXA-213; beta-lactamase class D OXA-213 [EC:3.5.2.6]
K19319 blaOXA-134; beta-lactamase class D OXA-134 [EC:3.5.2.6]
K19320 blaOXA-211; beta-lactamase class D OXA-211 [EC:3.5.2.6]
K19321 blaOXA-214; beta-lactamase class D OXA-214 [EC:3.5.2.6]
K19322 blaOXA-229; beta-lactamase class D OXA-229 [EC:3.5.2.6]
K20319 blaADC; beta-lactamase class C ADC [EC:3.5.2.6]
K20320 blaPDC; beta-lactamase class C PDC [EC:3.5.2.6]
K21266 blaOXA-286; beta-lactamase class D OXA-286 [EC:3.5.2.6]
K21276 blaOXA-22; beta-lactamase class D OXA-22 [EC:3.5.2.6]
K21277 blaOXA-60; beta-lactamase class D OXA-60 [EC:3.5.2.6]
K22331 blaOXA-184; beta-lactamase class D OXA-184 [EC:3.5.2.6]
K22332 blaOXA-548; beta-lactamase class D OXA-548 [EC:3.5.2.6]
K22333 blaOXA-493; beta-lactamase class D OXA-493 [EC:3.5.2.6]
K22334 blaOXA-464; beta-lactamase class D OXA-464 [EC:3.5.2.6]
K22335 blaOXA-114; beta-lactamase class D OXA-114 [EC:3.5.2.6]
K22346 blaSME; beta-lactamase class A SME [EC:3.5.2.6]
K22351 blaOXA-209; beta-lactamase class D OXA-209 [EC:3.5.2.6]
K22352 blaOXA-29; beta-lactamase class D OXA-29 [EC:3.5.2.6]
K24153 blaOXY; beta-lactamase class A OXY [EC:3.5.2.6]
K24159 blaLAP; beta-lactamase class A LAP [EC:3.5.2.6]
K24161 blaGOP; beta-lactamase class B GOB [EC:3.5.2.6]
K24162 blaBlaB; beta-lactamase class B BlaB [EC:3.5.2.6]
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3.5.2.7 imidazolonepropionase
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3.5.2.9 5-oxoprolinase (ATP-hydrolysing)
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3.5.2.10 creatininase
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3.5.2.11 L-lysine-lactamase
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3.5.2.12 6-aminohexanoate-cyclic-dimer hydrolase
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3.5.2.13 2,5-dioxopiperazine hydrolase
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3.5.2.14 N-methylhydantoinase (ATP-hydrolysing)
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3.5.2.15 cyanuric acid amidohydrolase
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3.5.2.16 maleimide hydrolase
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3.5.2.17 hydroxyisourate hydrolase
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3.5.2.18 enamidase
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3.5.2.19 streptothricin hydrolase
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3.5.2.20 isatin hydrolase
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3.5.3 In linear amidines
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3.5.4 In cyclic amidines
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3.5.5 In nitriles
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3.5.99 In other compounds
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3.6 Acting on acid anhydrides
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3.7 Acting on carbon-carbon bonds
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3.8 Acting on halide bonds
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3.9 Acting on phosphorus-nitrogen bonds
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3.10 Acting on sulfur-nitrogen bonds
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3.11 Acting on carbon-phosphorus bonds
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3.12 Acting on sulfur-sulfur bonds
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3.13 Acting on carbon-sulfur bonds
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4. Lyases
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5. Isomerases
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6. Ligases
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7. Translocases
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Enzymes