Peptidases and Inhibitors

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 Aspartic peptidases
 
 Cysteine peptidases
 
 Glutamic peptidases
 
 Metallo peptidases
 
 Asparagine peptide lyases
 
 Mixed peptidases
 
 Serine peptidases
   Family S1: chymotrypsin family
     K01310  CTRB; chymotrypsin [EC:3.4.21.1]
     K08661  MCPT1; mast cell peptidase 1 [EC:3.4.21.-]
     K08662  MCPT2; mast cell peptidase 2 [EC:3.4.21.-]
     K01340  E3.4.21.59; tryptase [EC:3.4.21.59]
     K09614  CORIN; atrial natriuretic peptide-converting enzyme [EC:3.4.21.-]
     K01362  OVCH; ovochymase [EC:3.4.21.-]
     K20111  OVCH2; oviductin [EC:3.4.21.120]
     K09615  TPSG1; tryptase gamma 1 [EC:3.4.21.-]
     K08648  HABP2; hyaluronan binding protein 2 [EC:3.4.21.-]
     K20751  E3.4.21.99; spermosin [EC:3.4.21.99]
     K20752  E3.4.21.49; hypodermin C [EC:3.4.21.49]
     K01312  PRSS1_2_3; trypsin [EC:3.4.21.4]
     K01316  TMPRSS15, PRSS7; enterokinase [EC:3.4.21.9]
     K08664  PRSS8; prostasin [EC:3.4.21.-]
     K09624  PRSS12; neurotrypsin [EC:3.4.21.-]
     K09625  PRSS21; testisin [EC:3.4.21.-]
     K09626  PRSS22, BSSP4; brain-specific serine protease 4 [EC:3.4.21.-]
     K09628  PRSS27; serine protease 27 [EC:3.4.21.-]
     K09629  PRSS33; serine protease 33 [EC:3.4.21.-]
     K09630  PRSS36; polyserase 2 [EC:3.4.21.-]
     K25708  PRSS53; serine protease 53 [EC:3.4.21.-]
     K23440  PRSS56; serine protease 56 [EC:3.4.21.-]
     K23011  PRSS57, NSP4; serine protease 57 [EC:3.4.21.-]
     K22367  PRSS58; serine protease 58 [EC:3.4.21.-]
     K01327  ELANE; leukocyte elastase [EC:3.4.21.37]
     K01319  CTSG; cathepsin G [EC:3.4.21.20]
     K01350  PRTN3; myeloblastin [EC:3.4.21.76]
     K01352  GZMA; granzyme A [EC:3.4.21.78]
     K01353  GZMB; granzyme B [EC:3.4.21.79]
     K09616  GZMH, CTSGL2; granzyme H (cathepsin G-like 2) [EC:3.4.21.-]
     K08663  GZMK; granzyme K [EC:3.4.21.-]
     K08649  GZMM; granzyme M [EC:3.4.21.-]
     K01329  CMA1; chymase [EC:3.4.21.39]
     K01326  CELA1; pancreatic elastase I [EC:3.4.21.36]
     K01346  CELA2; pancreatic elastase II [EC:3.4.21.71]
     K01345  CELA3; pancreatic endopeptidase E [EC:3.4.21.70]
     K01311  CTRC; chymotrypsin C [EC:3.4.21.2]
     K01325  KLK1_2; tissue kallikrein [EC:3.4.21.35]
     K01324  KLKB1; plasma kallikrein [EC:3.4.21.34]
     K01351  KLK3, PSA; semenogelase [EC:3.4.21.77]
     K08666  KLK4, PRSS17; kallikrein 4 [EC:3.4.21.-]
     K09617  KLK5; kallikrein 5 [EC:3.4.21.-]
     K08667  KLK6, PRSS9; kallikrein 6 [EC:3.4.21.-]
     K08668  KLK7, PRSS6; kallikrein 7 [EC:3.4.21.117]
     K08650  KLK8, PRSS19; kallikrein 8 [EC:3.4.21.118]
     K09618  KLK9; kallikrein 9 [EC:3.4.21.-]
     K09619  KLK10, PRSSL1; kallikrein 10 [EC:3.4.21.-]
     K09620  KLK11, PRSS20; kallikrein 11 [EC:3.4.21.-]
     K09462  E3.4.21.119; glandular kallikrein 13 [EC:3.4.21.119]
     K09621  KLK12; kallikrein 12 [EC:3.4.21.-]
     K09463  KLK13; kallikrein 13 [EC:3.4.21.119]
     K09622  KLK14; kallikrein 14 [EC:3.4.21.-]
     K09623  KLK15; kallikrein 15 [EC:3.4.21.-]
     K01339  KLK16; g-renin [EC:3.4.21.54]
     K20137  BX; venombin A [EC:3.4.21.74]
     K24791  C1RL; complement C1r subcomponent-like protein [EC:3.4.21.-]
     K03992  MASP1; mannan-binding lectin serine protease 1 [EC:3.4.21.-]
     K03993  MASP2; mannan-binding lectin serine protease 2 [EC:3.4.21.104]
     K01330  C1R; complement component 1, r subcomponent [EC:3.4.21.41]
     K01331  C1S; complement component 1, s subcomponent [EC:3.4.21.42]
     K01332  C2; complement component 2 [EC:3.4.21.43]
     K01335  CFB; complement factor B [EC:3.4.21.47]
     K01334  CFD; complement factor D [EC:3.4.21.46]
     K01333  CFI; complement factor I [EC:3.4.21.45]
     K24132  Sp7; serine protease 7 [EC:3.4.21.-]
     K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
     K01320  F7; coagulation factor VII [EC:3.4.21.21]
     K01321  F9; coagulation factor IX (Christmas factor) [EC:3.4.21.22]
     K01314  F10; coagulation factor X [EC:3.4.21.6]
     K01323  F11; coagulation factor XI [EC:3.4.21.27]
     K01328  F12; coagulation factor XII (Hageman factor) [EC:3.4.21.38]
     K01344  PROC; protein C (activated) [EC:3.4.21.69]
     K22079  E3.4.21.84; limulus clotting factor C [EC:3.4.21.84]
     K22080  E3.4.21.85; limulus clotting factor B [EC:3.4.21.85]
     K20753  E3.4.21.86; limulus clotting enzyme [EC:3.4.21.86]
     K01317  ACR; acrosin [EC:3.4.21.10]
     K08665  HPN; hepsin [EC:3.4.21.106]
     K24133  Sb; serine proteinase stubble [EC:3.4.21.-]
     K09631  HGFAC; hepatocyte growth factor activator [EC:3.4.21.-]
     K01343  PLAT; tissue plasminogen activator [EC:3.4.21.68]
     K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]
     K01315  PLG; plasminogen [EC:3.4.21.7]
     K09633  TMPRSS2; transmembrane protease serine 2 [EC:3.4.21.122]
     K09634  TMPRSS3; transmembrane protease serine 3 [EC:3.4.21.-]
     K09635  TMPRSS4; transmembrane protease serine 4 [EC:3.4.21.-]
     K09636  TMPRSS5; transmembrane protease serine 5 [EC:3.4.21.-]
     K09637  TMPRSS6; transmembrane protease serine 6 [EC:3.4.21.-]
     K09638  TMPRSS7; transmembrane protease serine 7 [EC:3.4.21.-]
     K09639  TMPRSS8; transmembrane protease serine 8 [EC:3.4.21.-]
     K09640  TMPRSS9; transmembrane protease serine 9 [EC:3.4.21.-]
     K09750  TMPRSS11A; transmembrane protease serine 11A [EC:3.4.21.-]
     K09751  TMPRSS11B; transmembrane protease serine 11B [EC:3.4.21.-]
     K14359  TMPRSS11C; transmembrane protease serine 11C [EC:3.4.21.-]
     K09641  TMPRSS11D; transmembrane protease serine 11D [EC:3.4.21.-]
     K09642  TMPRSS11E; transmembrane protease serine 11E [EC:3.4.21.-]
     K09752  TMPRSS11F; transmembrane protease serine 11F [EC:3.4.21.-]
     K18769  TMPRSS11G; transmembrane protease serine 11G [EC:3.4.21.-]
     K09643  TMPRSS13, TMPRSS11; transmembrane protease serine 13
     K09632  CTRL; chymotrypsin-like protease [EC:3.4.21.-]
     K04775  ydgD; protease YdgD [EC:3.4.21.-]
     K08670  ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]
     K20671  PSH; serine protease persephone [EC:3.4.21.-]
     K23489  SVH1, Teq; HGF/MSP/plasminogen-like protein
     K20672  SPE; spatzle-processing enzyme [EC:3.4.21.-]
     K20673  GRASS; gram-positive specific serine protease [EC:3.4.21.-]
     K20674  MODSP; modular serine protease [EC:3.4.21.-]
     K24665  AZU1; azurocidin
     K16142  HP; haptoglobin
     K23441  MST1; hepatocyte growth factor-like protein
     K09644  LPA; apolipoprotein(a) [EC:3.4.21.-]
     K20675  SPIRIT; serine protease immune response integrator
     K20677  HAYAN; serine protease Hayan [EC:3.4.21.-]
     K20676  SPHEROIDE; spheroide [EC:3.4.21.-]
     K01318  sspA; glutamyl endopeptidase [EC:3.4.21.19]
     K04771  degP, htrA; serine protease Do [EC:3.4.21.107]
     K04772  degQ, hhoA; serine protease DegQ [EC:3.4.21.-]
     K04691  hhoB, degS; serine protease DegS [EC:3.4.21.-]
     K08784  HTRA1, PRSS11; HtrA serine peptidase 1 [EC:3.4.21.-]
     K08669  HTRA2, PRSS25; HtrA serine peptidase 2 [EC:3.4.21.108]
     K08785  HTRA3; HtrA serine peptidase 3 [EC:3.4.21.-]
     K08786  HTRA4; HtrA serine peptidase 4 [EC:3.4.21.-]
     K23012  TYSND1; peroxisomal leader peptide-processing protease [EC:3.4.21.-]
     K25895  DEGP1; protease Do-like 1, chloroplastic [EC:3.4.21.-]
     K25896  DEGP2; protease Do-like 2, chloroplastic [EC:3.4.21.-]
     K25897  DEGP9; protease Do-like 9 [EC:3.4.21.-]
     K08372  pepD; putative serine protease PepD [EC:3.4.21.-]
     K01337  E3.4.21.50; lysyl endopeptidase [EC:3.4.21.50]
     K09627  PRSS23; serine protease 23 [EC:3.4.21.-]
     K22686  NMA111; pro-apoptotic serine protease NMA111 [EC:3.4.21.-]
     K18544  sprA; streptogrisin A [EC:3.4.21.80]
     K18545  sprB; streptogrisin B [EC:3.4.21.81]
     K18546  sprC; streptogrisin C [EC:3.4.21.-]
     K18547  sprD; streptogrisin D [EC:3.4.21.-]
     K18548  sprE; glutamyl endopeptidase II [EC:3.4.21.82]
     K20136  alpha-LP; alpha-lytic endopeptidase [EC:3.4.21.12]
   Family S3: togavirin family
   Family S6
   Family S7: flavivirin family
   Family S8: subtilisin family
   Family S9: prolyl oligopeptidase family
   Family S10
   Family S11: D-Ala-D-Ala carboxypeptidase A family
   Family S12: D-Ala-D-Ala carboxypeptidase B family
   Family S13: D-Ala-D-Ala peptidase C family
   Family S14: ClpP endopeptidase family
   Family S15
   Family S16: lon protease family
   Family S21: assemblin family
   Family S24: LexA family
   Family S26: signal peptidase I family
   Family S28
   Family S31
   Family S32
   Family S33
   Family S41: C-terminal processing peptidase family
   Family S45
   Family S49: protease IV family
   Family S50
   Family S51
   Family S53
   Family S54: Rhomboid family
   Family S55: SpoIVB peptidase family
   Family S62
   Family S66
   Family S77: phage prohead processing peptidase family
   Family S78
 
 Threonine peptidases
 
 Peptidases of unknown catalytic type
 
 Peptidase inhibitors

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Last updated: December 13, 2023
Classification taken and modified from MEROPS