Ubiquitin System

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 Ubiquitins and ubiquitin-like proteins
 
 Ubiquitin-activating enzymes (E1)
 
 Ubiquitin-conjugating enzymes (E2)
 
 Ubiquitin ligases (E3)
   HECT type E3
   U-box type E3
   Single Ring-finger type E3
   Atypical E3
   UBL E3 ligases
   Multi subunit Ring-finger type E3
     SCF complex
       Ring finger protein
       Cullin
       Adaptor protein
       Target recognizing subunit (F-box)
         K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
         K10261  FBXW2, MD6; F-box and WD-40 domain protein 2
         K10262  FBXW4, SHFM3; F-box and WD-40 domain protein 4
         K10263  FBXW5; F-box and WD-40 domain protein 5
         K10260  FBXW7, SEL10; F-box and WD-40 domain protein 7
         K10264  FBXW8; F-box and WD-40 domain protein 8
         K10265  FBXW9; F-box and WD-40 domain protein 9
         K10266  FBXW10; F-box and WD-40 domain protein 10
         K10267  FBXW12S; F-box and WD-40 domain protein 12/13/14/15/16/17/19
         K10259  MET30; F-box and WD-40 domain protein MET30
         K03361  CDC4; F-box and WD-40 domain protein CDC4
         K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
         K10268  FBXL2_20; F-box and leucine-rich repeat protein 2/20
         K10269  FBXL3; F-box and leucine-rich repeat protein 3
         K10270  FBXL4; F-box and leucine-rich repeat protein 4
         K10271  FBXL5; F-box and leucine-rich repeat protein 5
         K10272  FBXL6; F-box and leucine-rich repeat protein 6
         K10273  FBXL7; F-box and leucine-rich repeat protein 7
         K10274  FBXL8; F-box and leucine-rich repeat protein 8
         K10275  FBXL9, LRRC29; F-box and leucine-rich repeat protein 9
         K10276  FBXL10_11, KDM2; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
         K10278  FBXL12; F-box and leucine-rich repeat protein 12
         K10279  FBXL13, DRC6; dynein regulatory complex subunit 6
         K10280  FBXL14; F-box and leucine-rich repeat protein 14
         K10281  FBXL15; F-box and leucine-rich repeat protein 15
         K10282  FBXL16; F-box and leucine-rich repeat protein 16
         K10283  FBXL17; F-box and leucine-rich repeat protein 17
         K10284  FBXL18; F-box and leucine-rich repeat protein 18
         K10285  FBXL19; F-box and leucine-rich repeat protein 19
         K10287  FBXL21; F-box and leucine-rich repeat protein 21
         K10288  FBXL22; F-box and leucine-rich repeat protein 22
         K13463  COI-1; coronatine-insensitive protein 1
         K14515  EBF1_2; EIN3-binding F-box protein
         K14485  TIR1; transport inhibitor response 1
         K03360  GRR1; F-box and leucine-rich repeat protein GRR1
         K15068  DIA2, POF3; protein DIA2
         K15069  POF3; F-box/TPR repeat protein Pof3
         K10289  CCNF, FBXO1; F-box protein 1 (cyclin F)
         K10099  FBXO2, NFB42; F-box protein 2
         K10290  FBXO3; F-box protein 3
         K10291  FBXO4; F-box protein 4
         K10292  FBXO5, EMI1; F-box protein 5
         K10100  FBXO6; F-box protein 6
         K10293  FBXO7; F-box protein 7
         K10294  FBXO8; F-box protein 8
         K10295  FBXO9; F-box protein 9
         K10296  FBXO10; F-box protein 10
         K10297  FBXO11; F-box protein 11
         K10298  FBXO15; F-box protein 15
         K10299  FBXO16; F-box protein 16
         K10101  FBXO17, FBXO26; F-box protein 17
         K10300  FBH1, FBXO18; F-box DNA helicase 1 [EC:5.6.2.4]
         K06084  LMO7, FBXO20; F-box protein 20
         K10301  FBXO21; F-box protein 21
         K10302  FBXO22; F-box protein 22
         K10303  FBXO23, TSPAN17; F-box protein 23
         K10304  FBXO24; F-box protein 24
         K10305  FBXO25_32; F-box protein 25/32
         K10102  FBXO27; F-box protein 27
         K10306  FBXO28; F-box protein 28
         K10307  FBXO30; F-box protein 30
         K10308  FBXO31; F-box protein 31
         K10310  FBXO33; F-box protein 33
         K10311  FBXO34; F-box protein 34
         K10312  FBXO36; F-box protein 36
         K10313  FBXO38, MOKA; F-box protein 38
         K10314  FBXO39; F-box protein 39
         K10315  FBXO40; F-box protein 40
         K10316  FBXO41; F-box protein 41
         K10317  FBXO42; F-box protein 42
         K10318  FBXO43, EMI2; F-box protein 43
         K10103  FBXO44; F-box protein 44
         K10319  FBXO45; F-box protein 45
         K10320  FBXO46; F-box protein 46
         K10321  FBXO47; F-box protein 47
         K27313  FBXO48; F-box protein 48
         K12116  FKF1; flavin-binding kelch repeat F-box protein 1
         K14495  GID2, SLY1; F-box protein GID2
         K27314  SNE, SLY2; F-box protein SNE
         K12117  LKP2; LOV kelch protein 2
         K12115  ZTL; clock-associated PAS protein ZTL
         K15070  MDM30; mitochondrial distribution and morphology protein 30
         K15071  RCY1, POF6; recyclin-1
         K15072  SAF1; SCF-associated factor 1
         K15073  UFO1; ubiquitin ligase complex F-box protein UFO1
     Cul2 complex
     Cul3 complex
     Cul4 complex
     Cul5 complex
     Cul7 complex
     Cul8 complex
     Cul9 complex
     APC/C
     BRCC complex
     KPC complex
     LUBAC complex
     CTLH complex
     ERAD complex
     LMBR1L-GP78-UBAC2 complex
     SLX5-SLX8 complex
     Multi subunit type E3 associated proteins
 
 Deubiquitinating enzyme (DUB)

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Last updated: April 5, 2024