Messenger RNA Biogenesis - Mus musculus (house mouse)

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     KO 
 Eukaryotic type

   mRNA processing factors

   mRNA surveillance and transport factors

     Transport factors

     Surveillance factors

     Factors involved in mRNA localization

     mRNA cycle factors

       Common to processing body (P body) and stress granule

       P-body specific factors

         70640 Dcp2; decapping mRNA 2
         75901 Dcp1a; decapping mRNA 1A
         319618 Dcp1b; decapping mRNA 1B
         67207 Lsm1; LSM1 homolog, mRNA degradation associated
         27756 Lsm2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
         67678 Lsm3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
         50783 Lsm4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
         66373 Lsm5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
         78651 Lsm6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
         66094 Lsm7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
         76522 Lsm8; LSM8 homolog, U6 small nuclear RNA associated
         16593 Klc1; kinesin light chain 1
         16594 Klc2; kinesin light chain 2
         232943 Klc3; kinesin light chain 3
         74764 Klc4; kinesin light chain 4
         17918 Myo5a; myosin VA
         17919 Myo5b; myosin VB
         208943 Myo5c; myosin VC
         22145 Tuba4a; tubulin, alpha 4A
         22144 Tuba3a; tubulin, alpha 3A
         22142 Tuba1a; tubulin, alpha 1A
         22146 Tuba1c; tubulin, alpha 1C
         22147 Tuba3b; tubulin, alpha 3B
         22143 Tuba1b; tubulin, alpha 1B
         53857 Tuba8; tubulin, alpha 8
         238463 Tubal3; tubulin, alpha-like 3
         12877 Cpeb1; cytoplasmic polyadenylation element binding protein 1
         208922 Cpeb3; cytoplasmic polyadenylation element binding protein 3
         231207 Cpeb2; cytoplasmic polyadenylation element binding protein 2
         67579 Cpeb4; cytoplasmic polyadenylation element binding protein 4
         216766 Gemin5; gem nuclear organelle associated protein 5
         21335 Tacc3; transforming, acidic coiled-coil containing protein 3
         233833 Tnrc6a; trinucleotide repeat containing 6a
         213988 Tnrc6b; trinucleotide repeat containing 6b
         217351 Tnrc6c; trinucleotide repeat containing 6C
         234594 Cnot1; CCR4-NOT transcription complex, subunit 1
         72068 Cnot2; CCR4-NOT transcription complex, subunit 2
         232791 Cnot3; CCR4-NOT transcription complex, subunit 3
         53621 Cnot4; CCR4-NOT transcription complex, subunit 4
         104625 Cnot6; CCR4-NOT transcription complex, subunit 6
         231464 Cnot6l; CCR4-NOT transcription complex, subunit 6-like
         18983 Cnot7; CCR4-NOT transcription complex, subunit 7
         69125 Cnot8; CCR4-NOT transcription complex, subunit 8
         233103 Garre1; granule associated Rac and RHOG effector 1
         208718 Dis3l2; DIS3 like 3'-5' exoribonuclease 2
         103135 Pan2; PAN2 poly(A) specific ribonuclease subunit
         72587 Pan3; PAN3 poly(A) specific ribonuclease subunit
         12226 Btg1; BTG anti-proliferation factor 1
         12227 Btg2; BTG anti-proliferation factor 2
         12228 Btg3; BTG anti-proliferation factor 3
         194735 Btg1c; BTG anti-proliferation factor 1C
         22057 Tob1; transducer of ErbB-2.1
         436199 Btg1b; BTG anti-proliferation factor 1B
         56057 Btg4; BTG anti-proliferation factor 4
         57259 Tob2; transducer of ERBB2, 2
         74203 Eif4enif1; eukaryotic translation initiation factor 4E nuclear import factor 1
         225929 Patl1; protein associated with topoisomerase II homolog 1 (yeast)
         353190 Edc3; enhancer of mRNA decapping 3
         234699 Edc4; enhancer of mRNA decapping 4
         378430 Nanos2; nanos C2HC-type zinc finger 2
         244551 Nanos3; nanos C2HC-type zinc finger 3
         326622 Upf2; UPF2 regulator of nonsense transcripts homolog (yeast)
         68134 Upf3b; UPF3 regulator of nonsense transcripts homolog B (yeast)
         67031 Upf3a; UPF3 regulator of nonsense transcripts homolog A (yeast)
         20821 Trim21; tripartite motif-containing 21
         636931 Trim71; tripartite motif-containing 71
         67710 Polr2g; polymerase (RNA) II (DNA directed) polypeptide G
         19106 Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2
         317755 Zar1; zygote arrest 1
         545824 Zar1l; zygote arrest 1-like
         213541 Ythdf2; YTH N6-methyladenosine RNA binding protein 2
         228994 Ythdf1; YTH N6-methyladenosine RNA binding protein 1
         229096 Ythdf3; YTH N6-methyladenosine RNA binding protein 3

K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62] 
K12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-] 
K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-] 
K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 
K10407 KLC; kinesin light chain 
K10407 KLC; kinesin light chain 
K10407 KLC; kinesin light chain 
K10407 KLC; kinesin light chain 
K10357 MYO5; myosin V 
K10357 MYO5; myosin V 
K10357 MYO5; myosin V 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K07374 TUBA; tubulin alpha 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
K13133 GEMIN5; gem associated protein 5 
K14283 TACC3; transforming acidic coiled-coil-containing protein 3 
K18412 TNRC6; trinucleotide repeat-containing gene 6 protein 
K18412 TNRC6; trinucleotide repeat-containing gene 6 protein 
K18412 TNRC6; trinucleotide repeat-containing gene 6 protein 
K12604 CNOT1; CCR4-NOT transcription complex subunit 1 
K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
K12580 CNOT3; CCR4-NOT transcription complex subunit 3 
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27] 
K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
K26671 GARRE1; granule associated Rac and RHOG effector protein 1 
K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-] 
K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K14443 TOB; protein Tob/BTG 
K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter 
K12617 PATL1; DNA topoisomerase 2-associated protein PAT1 
K12615 EDC3; enhancer of mRNA-decapping protein 3 
K12616 EDC4; enhancer of mRNA-decapping protein 4 
K18760 NANOS2; protein nanos 2 
K18761 NANOS3; protein nanos 3 
K14327 UPF2; regulator of nonsense transcripts 2 
K14328 UPF3; regulator of nonsense transcripts 3 
K14328 UPF3; regulator of nonsense transcripts 3 
K10651 TRIM21; tripartite motif-containing protein 21 [EC:2.3.2.27] 
K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27] 
K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1] 
K18762 ZAR1; zygote arrest protein 1 
K18762 ZAR1; zygote arrest protein 1 
K20102 YTHDF; YTH domain-containing family protein 
K20102 YTHDF; YTH domain-containing family protein 
K20102 YTHDF; YTH domain-containing family protein 

       Stress granule specific factors

   mRNA degradation factors

     5'-3' decay

     3'-5' decay

       Core exosome factors

       Exosome cofactors

       TRAMP complex

       Ski complex

       Ccr4-NOT complex

       Pan complex

         103135 Pan2; PAN2 poly(A) specific ribonuclease subunit
         72587 Pan3; PAN3 poly(A) specific ribonuclease subunit

K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 

       Other 3'-5' decay factors

     Other degradation factors

 





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Last updated: April 9, 2024