1. Oxidoreductases

 2. Transferases

 3. Hydrolases

 4. Lyases

   4.1  Carbon-carbon lyases

     4.1.1  Carboxy-lyases

       4.1.1.1  pyruvate decarboxylase

       4.1.1.2  oxalate decarboxylase

       4.1.1.4  acetoacetate decarboxylase

       4.1.1.5  acetolactate decarboxylase

       4.1.1.6  cis-aconitate decarboxylase

       4.1.1.7  benzoylformate decarboxylase

       4.1.1.8  oxalyl-CoA decarboxylase

       4.1.1.9  malonyl-CoA decarboxylase

       4.1.1.11  aspartate 1-decarboxylase

       4.1.1.12  aspartate 4-decarboxylase

       4.1.1.14  valine decarboxylase

       4.1.1.15  glutamate decarboxylase

       4.1.1.16  hydroxyglutamate decarboxylase

       4.1.1.17  ornithine decarboxylase

       4.1.1.18  lysine decarboxylase

       4.1.1.19  arginine decarboxylase

       4.1.1.20  diaminopimelate decarboxylase

       4.1.1.21  phosphoribosylaminoimidazole carboxylase

       4.1.1.22  histidine decarboxylase

       4.1.1.23  orotidine-5'-phosphate decarboxylase

       4.1.1.24  aminobenzoate decarboxylase

       4.1.1.25  tyrosine decarboxylase

       4.1.1.28  aromatic-L-amino-acid decarboxylase

       4.1.1.29  sulfinoalanine decarboxylase

       4.1.1.30  pantothenoylcysteine decarboxylase

       4.1.1.31  phosphoenolpyruvate carboxylase

       4.1.1.32  phosphoenolpyruvate carboxykinase (GTP)

       4.1.1.33  diphosphomevalonate decarboxylase

       4.1.1.34  dehydro-L-gulonate decarboxylase

       4.1.1.35  UDP-glucuronate decarboxylase

       4.1.1.36  phosphopantothenoylcysteine decarboxylase

       4.1.1.37  uroporphyrinogen decarboxylase

       4.1.1.38  phosphoenolpyruvate carboxykinase (diphosphate)

       4.1.1.39  ribulose-bisphosphate carboxylase

       4.1.1.40  hydroxypyruvate decarboxylase

       4.1.1.42  carnitine decarboxylase

       4.1.1.43  phenylpyruvate decarboxylase

       4.1.1.44  4-carboxymuconolactone decarboxylase

       4.1.1.45  aminocarboxymuconate-semialdehyde decarboxylase

       4.1.1.46  o-pyrocatechuate decarboxylase

       4.1.1.47  tartronate-semialdehyde synthase

       4.1.1.48  indole-3-glycerol-phosphate synthase

       4.1.1.49  phosphoenolpyruvate carboxykinase (ATP)

       4.1.1.50  adenosylmethionine decarboxylase

       4.1.1.51  3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase

       4.1.1.52  6-methylsalicylate decarboxylase

       4.1.1.53  phenylalanine decarboxylase

       4.1.1.54  dihydroxyfumarate decarboxylase

       4.1.1.55  4,5-dihydroxyphthalate decarboxylase

       4.1.1.56  3-oxolaurate decarboxylase

       4.1.1.57  methionine decarboxylase

       4.1.1.58  orsellinate decarboxylase

       4.1.1.59  gallate decarboxylase

       4.1.1.60  stipitatonate decarboxylase

       4.1.1.61  4-hydroxybenzoate decarboxylase

       4.1.1.62  gentisate decarboxylase

       4.1.1.63  protocatechuate decarboxylase

       4.1.1.64  2,2-dialkylglycine decarboxylase (pyruvate)

       4.1.1.65  phosphatidylserine decarboxylase

       4.1.1.66  uracil-5-carboxylate decarboxylase

       4.1.1.67  UDP-galacturonate decarboxylase

       4.1.1.68  5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

       4.1.1.69  3,4-dihydroxyphthalate decarboxylase

       4.1.1.71  2-oxoglutarate decarboxylase

       4.1.1.72  branched-chain-2-oxoacid decarboxylase

       4.1.1.73  tartrate decarboxylase

       4.1.1.74  indolepyruvate decarboxylase

       4.1.1.75  5-guanidino-2-oxopentanoate decarboxylase

       4.1.1.76  arylmalonate decarboxylase

       4.1.1.77  2-oxo-3-hexenedioate decarboxylase

       4.1.1.78  acetylenedicarboxylate decarboxylase

       4.1.1.79  sulfopyruvate decarboxylase

       4.1.1.80  4-hydroxyphenylpyruvate decarboxylase

       4.1.1.81  threonine-phosphate decarboxylase

       4.1.1.82  phosphonopyruvate decarboxylase

       4.1.1.83  4-hydroxyphenylacetate decarboxylase

       4.1.1.84  D-dopachrome decarboxylase

       4.1.1.85  3-dehydro-L-gulonate-6-phosphate decarboxylase

       4.1.1.86  diaminobutyrate decarboxylase

       4.1.1.87  malonyl-[malonate decarboxylase] decarboxylase

       4.1.1.88  biotin-independent malonate decarboxylase

       4.1.1.90  peptidyl-glutamate 4-carboxylase

       4.1.1.91  salicylate decarboxylase

       4.1.1.92  indole-3-carboxylate decarboxylase

       4.1.1.93  pyrrole-2-carboxylate decarboxylase

       4.1.1.94  ethylmalonyl-CoA decarboxylase

       4.1.1.95  L-glutamyl-[BtrI acyl-carrier protein] decarboxylase

       4.1.1.96  carboxynorspermidine decarboxylase

       4.1.1.97  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

       4.1.1.98  4-hydroxy-3-polyprenylbenzoate decarboxylase

       4.1.1.99  phosphomevalonate decarboxylase

       4.1.1.100  prephenate decarboxylase

       4.1.1.101  malolactic enzyme

       4.1.1.102  phenacrylate decarboxylase

       4.1.1.103  gamma-resorcylate decarboxylase

       4.1.1.104  3-dehydro-4-phosphotetronate decarboxylase

       4.1.1.105  L-tryptophan decarboxylase

       4.1.1.106  fatty acid photodecarboxylase

       4.1.1.107  3,4-dihydroxyphenylacetaldehyde synthase

       4.1.1.108  4-hydroxyphenylacetaldehyde synthase

       4.1.1.109  phenylacetaldehyde synthase

       4.1.1.110  bisphosphomevalonate decarboxylase

       4.1.1.111  siroheme decarboxylase

       4.1.1.112  oxaloacetate decarboxylase

       4.1.1.113  trans-aconitate decarboxylase

       4.1.1.114  cis-3-alkyl-4-alkyloxetan-2-one decarboxylase

       4.1.1.115  indoleacetate decarboxylase

       4.1.1.116  D-ornithine/D-lysine decarboxylase

       4.1.1.117  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase

       4.1.1.118  isophthalyl-CoA decarboxylase

       4.1.1.119  phenylacetate decarboxylase

       4.1.1.120  3-oxoisoapionate decarboxylase

       4.1.1.121  3-oxoisoapionate-4-phosphate decarboxylase

       4.1.1.122  L-cysteate decarboxylase

       4.1.1.123  phenyl-phosphate phosphatase/carboxylase

       4.1.1.124  malonyl-[acp] decarboxylase

       4.1.1.125  4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase

       4.1.1.126  anhydromevalonate phosphate decarboxylase

       4.1.1.127  carboxyaminopropylagmatine decarboxylase

     4.1.2  Aldehyde-lyases

     4.1.3  Oxo-acid-lyases

     4.1.99  Other carbon-carbon lyases

   4.2  Carbon-oxygen lyases

   4.3  Carbon-nitrogen lyases

   4.4  Carbon-sulfur lyases

   4.5  Carbon-halide lyases

   4.6  Phosphorus-oxygen lyases

   4.7  carbon-phosphorus lyases

   4.8  Nitrogen-oxygen lyases

   4.98  ATP-independent chelatases

   4.99  Other lyases

 5. Isomerases

 6. Ligases

   6.1  Forming carbon-oxygen bonds

   6.2  Forming carbon-sulfur bonds

   6.3  Forming carbon-nitrogen bonds

     6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)

     6.3.2  Acid-D-amino-acid ligases (peptide synthases)

       6.3.2.1  pantoate---beta-alanine ligase (AMP-forming)

       6.3.2.2  glutamate---cysteine ligase

       6.3.2.3  glutathione synthase

       6.3.2.4  D-alanine---D-alanine ligase

       6.3.2.5  phosphopantothenate---cysteine ligase (CTP)

       6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase

       6.3.2.7  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase

       6.3.2.8  UDP-N-acetylmuramate---L-alanine ligase

       6.3.2.9  UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase

       6.3.2.10  UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase

       6.3.2.11  carnosine synthase

       6.3.2.12  dihydrofolate synthase

       6.3.2.13  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase

       6.3.2.14  enterobactin synthase

       6.3.2.16  D-alanine---alanyl-poly(glycerolphosphate) ligase

       6.3.2.17  tetrahydrofolate synthase

       6.3.2.18  gamma-glutamylhistamine synthase

       6.3.2.20  indoleacetate---lysine synthetase

       6.3.2.23  homoglutathione synthase

       6.3.2.24  tyrosine---arginine ligase

       6.3.2.25  tubulin---tyrosine ligase

       6.3.2.26  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

       6.3.2.29  cyanophycin synthase (L-aspartate-adding)

       6.3.2.30  cyanophycin synthase (L-arginine-adding)

       6.3.2.31  coenzyme F420-0:L-glutamate ligase

       6.3.2.32  coenzyme gamma-F420-2:alpha-L-glutamate ligase

       6.3.2.33  tetrahydrosarcinapterin synthase

       6.3.2.34  coenzyme F420-1:gamma-L-glutamate ligase

       6.3.2.35  D-alanine---D-serine ligase

       6.3.2.36  4-phosphopantoate---beta-alanine ligase

       6.3.2.37  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---D-lysine ligase

       6.3.2.38  N2-citryl-N6-acetyl-N6-hydroxylysine synthase

       6.3.2.39  aerobactin synthase

       6.3.2.40  cyclopeptine synthase

       6.3.2.41  N-acetylaspartylglutamate synthase

       6.3.2.42  N-acetylaspartylglutamylglutamate synthase

       6.3.2.43  [amino-group carrier protein]---L-2-aminoadipate ligase

       6.3.2.44  pantoate---beta-alanine ligase (ADP-forming)

       6.3.2.45  UDP-N-acetylmuramate---L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase

       6.3.2.46  fumarate---(S)-2,3-diaminopropanoate ligase

       6.3.2.47  dapdiamide synthase

       6.3.2.48  L-arginine-specific L-amino acid ligase

       6.3.2.49  L-alanine---L-anticapsin ligase

       6.3.2.50  tenuazonic acid synthetase

       6.3.2.51  phosphopantothenate---cysteine ligase (ATP)

       6.3.2.52  jasmonoyl---L-amino acid ligase

       6.3.2.53  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase

       6.3.2.54  L-2,3-diaminopropanoate---citrate ligase

       6.3.2.55  2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase

       6.3.2.56  staphyloferrin B synthase

       6.3.2.57  staphyloferrin A synthase

       6.3.2.58  D-ornithine---citrate ligase

       6.3.2.59  3-methyl-D-ornithine---L-lysine ligase

       6.3.2.60  glutamate---[amino group carrier protein] ligase

       6.3.2.61  tubulin-glutamate ligase

       6.3.2.62  beta-tubulin-glutamate ligase

       6.3.2.63  putrebactin synthase

       6.3.2.64  bisucaberin synthase

     6.3.3  Cyclo-ligases

     6.3.4  Other carbon-nitrogen ligases

     6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor

   6.4  Forming carbon-carbon bonds

   6.5  Forming phosphoric-ester bonds

   6.6  Forming nitrogen-metal bonds

   6.7  Forming nitrogen-nitrogen bonds

 7. Translocases