Search BRITE hierarchies

KEGG Orthology (KO) [BR:hsa00001]
  09100 Metabolism
    09108 Metabolism of cofactors and vitamins
      00760 Nicotinate and nicotinamide metabolism [PATH:hsa00760]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
  09130 Environmental Information Processing
    09132 Signal transduction
      04310 Wnt signaling pathway [PATH:hsa04310]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
      04068 FoxO signaling pathway [PATH:hsa04068]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
      04152 AMPK signaling pathway [PATH:hsa04152]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
  09140 Cellular Processes
    09141 Transport and catabolism
      04148 Efferocytosis [PATH:hsa04148]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
    09143 Cell growth and death
      04218 Cellular senescence [PATH:hsa04218]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
  09150 Organismal Systems
    09152 Endocrine system
      04922 Glucagon signaling pathway [PATH:hsa04922]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
    09149 Aging
      04211 Longevity regulating pathway [PATH:hsa04211]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
      04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
  09160 Human Diseases
    09161 Cancer: overview
      05206 MicroRNAs in cancer [PATH:hsa05206]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
    09165 Substance dependence
      05031 Amphetamine addiction [PATH:hsa05031]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
    09167 Endocrine and metabolic disease
      04936 Alcoholic liver disease [PATH:hsa04936]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
  09180 Brite Hierarchies
    09182 Protein families: genetic information processing
      03036 Chromosome and associated proteins [BR:hsa03036]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
      03029 Mitochondrial biogenesis [BR:hsa03029]
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]

Enzymes [BR:hsa01000]
  2. Transferases
    2.3  Acyltransferases
      2.3.1  Transferring groups other than aminoacyl groups
        2.3.1.286  protein acetyllysine N-acetyltransferase
          23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286] 

Chromosome and associated proteins [BR:hsa03036]
  Eukaryotic type
    Histone modification proteins
      HDACs (histone deacetylases)
        SIRTs (sirtuins, class III HDACs)
          23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286] 

Mitochondrial biogenesis [BR:hsa03029]
  Mitochondrial quality control factors
    Regulator of mitochondrial biogenesis
      Other regulator of mitochondrial biogenesis
        23411 SIRT1; sirtuin 1	K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]