Search BRITE hierarchies

KEGG Orthology (KO) [BR:hsa00001]
  09130 Environmental Information Processing
    09132 Signal transduction
      04012 ErbB signaling pathway [PATH:hsa04012]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04371 Apelin signaling pathway [PATH:hsa04371]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04630 Jak-STAT signaling pathway [PATH:hsa04630]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04066 HIF-1 signaling pathway [PATH:hsa04066]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04072 Phospholipase D signaling pathway [PATH:hsa04072]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04151 PI3K-Akt signaling pathway [PATH:hsa04151]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04152 AMPK signaling pathway [PATH:hsa04152]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04150 mTOR signaling pathway [PATH:hsa04150]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
  09140 Cellular Processes
    09141 Transport and catabolism
      04140 Autophagy - animal [PATH:hsa04140]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04136 Autophagy - other [PATH:hsa04136]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09143 Cell growth and death
      04218 Cellular senescence [PATH:hsa04218]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
  09150 Organismal Systems
    09151 Immune system
      04659 Th17 cell differentiation [PATH:hsa04659]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09152 Endocrine system
      04910 Insulin signaling pathway [PATH:hsa04910]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04920 Adipocytokine signaling pathway [PATH:hsa04920]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04935 Growth hormone synthesis, secretion and action [PATH:hsa04935]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04919 Thyroid hormone signaling pathway [PATH:hsa04919]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09149 Aging
      04211 Longevity regulating pathway [PATH:hsa04211]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04213 Longevity regulating pathway - multiple species [PATH:hsa04213]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09159 Environmental adaptation
      04714 Thermogenesis [PATH:hsa04714]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
  09160 Human Diseases
    09161 Cancer: overview
      05200 Pathways in cancer [PATH:hsa05200]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05206 MicroRNAs in cancer [PATH:hsa05206]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05205 Proteoglycans in cancer [PATH:hsa05205]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05230 Central carbon metabolism in cancer [PATH:hsa05230]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05231 Choline metabolism in cancer [PATH:hsa05231]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09162 Cancer: specific types
      05210 Colorectal cancer [PATH:hsa05210]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05212 Pancreatic cancer [PATH:hsa05212]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05225 Hepatocellular carcinoma [PATH:hsa05225]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05226 Gastric cancer [PATH:hsa05226]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05214 Glioma [PATH:hsa05214]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05221 Acute myeloid leukemia [PATH:hsa05221]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05215 Prostate cancer [PATH:hsa05215]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05224 Breast cancer [PATH:hsa05224]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09167 Endocrine and metabolic disease
      04930 Type II diabetes mellitus [PATH:hsa04930]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      04931 Insulin resistance [PATH:hsa04931]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09171 Infectious disease: bacterial
      05131 Shigellosis [PATH:hsa05131]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09172 Infectious disease: viral
      05170 Human immunodeficiency virus 1 infection [PATH:hsa05170]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05168 Herpes simplex virus 1 infection [PATH:hsa05168]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05163 Human cytomegalovirus infection [PATH:hsa05163]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05167 Kaposi sarcoma-associated herpesvirus infection [PATH:hsa05167]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      05165 Human papillomavirus infection [PATH:hsa05165]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09176 Drug resistance: antineoplastic
      01521 EGFR tyrosine kinase inhibitor resistance [PATH:hsa01521]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
      01522 Endocrine resistance [PATH:hsa01522]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
  09180 Brite Hierarchies
    09181 Protein families: metabolism
      01001 Protein kinases [BR:hsa01001]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
    09182 Protein families: genetic information processing
      04131 Membrane trafficking [BR:hsa04131]
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]

Enzymes [BR:hsa01000]
  2. Transferases
    2.7  Transferring phosphorus-containing groups
      2.7.11  Protein-serine/threonine kinases
        2.7.11.1  non-specific serine/threonine protein kinase
          2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1] 

Protein kinases [BR:hsa01001]
  Serine/threonine kinases: Other
    PIKK family [OT]
      2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1] 

Membrane trafficking [BR:hsa04131]
  Autophagy
    Other autophagy associated proteins
      mTORC1 complex
        2475 MTOR; mechanistic target of rapamycin kinase	K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1] 

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