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KEGG Orthology (KO) [BR:cfa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway [PATH:cfa04010]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
04012 ErbB signaling pathway [PATH:cfa04012]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
04668 TNF signaling pathway [PATH:cfa04668]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway [PATH:cfa04620]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
04664 Fc epsilon RI signaling pathway [PATH:cfa04664]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09152 Endocrine system
04912 GnRH signaling pathway [PATH:cfa04912]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
04926 Relaxin signaling pathway [PATH:cfa04926]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
04935 Growth hormone synthesis, secretion and action [PATH:cfa04935]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species [PATH:cfa05208]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection [PATH:cfa05166]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
05161 Hepatitis B [PATH:cfa05161]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
05167 Kaposi sarcoma-associated herpesvirus infection [PATH:cfa05167]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
05169 Epstein-Barr virus infection [PATH:cfa05169]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09171 Infectious disease: bacterial
05132 Salmonella infection [PATH:cfa05132]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
05135 Yersinia infection [PATH:cfa05135]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09174 Infectious disease: parasitic
05142 Chagas disease [PATH:cfa05142]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09166 Cardiovascular disease
05417 Lipid and atherosclerosis [PATH:cfa05417]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
05418 Fluid shear stress and atherosclerosis [PATH:cfa05418]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease [PATH:cfa04936]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:cfa01001]
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Enzymes [BR:cfa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Protein kinases [BR:cfa01001]
Serine/threonine kinases: STE group
STE7 family
489508 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
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