Search BRITE hierarchies
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway [PATH:hsa04010]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04012 ErbB signaling pathway [PATH:hsa04012]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04014 Ras signaling pathway [PATH:hsa04014]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04015 Rap1 signaling pathway [PATH:hsa04015]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04370 VEGF signaling pathway [PATH:hsa04370]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04371 Apelin signaling pathway [PATH:hsa04371]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04668 TNF signaling pathway [PATH:hsa04668]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04066 HIF-1 signaling pathway [PATH:hsa04066]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04068 FoxO signaling pathway [PATH:hsa04068]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04072 Phospholipase D signaling pathway [PATH:hsa04072]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04071 Sphingolipid signaling pathway [PATH:hsa04071]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04024 cAMP signaling pathway [PATH:hsa04024]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04022 cGMP-PKG signaling pathway [PATH:hsa04022]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04151 PI3K-Akt signaling pathway [PATH:hsa04151]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04150 mTOR signaling pathway [PATH:hsa04150]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal [PATH:hsa04140]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04148 Efferocytosis [PATH:hsa04148]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09143 Cell growth and death
04114 Oocyte meiosis [PATH:hsa04114]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04210 Apoptosis [PATH:hsa04210]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04218 Cellular senescence [PATH:hsa04218]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09144 Cellular community - eukaryotes
04510 Focal adhesion [PATH:hsa04510]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04540 Gap junction [PATH:hsa04540]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09142 Cell motility
04810 Regulation of actin cytoskeleton [PATH:hsa04810]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation [PATH:hsa04613]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04620 Toll-like receptor signaling pathway [PATH:hsa04620]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04660 T cell receptor signaling pathway [PATH:hsa04660]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04662 B cell receptor signaling pathway [PATH:hsa04662]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04664 Fc epsilon RI signaling pathway [PATH:hsa04664]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04062 Chemokine signaling pathway [PATH:hsa04062]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09152 Endocrine system
04910 Insulin signaling pathway [PATH:hsa04910]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04929 GnRH secretion [PATH:hsa04929]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04912 GnRH signaling pathway [PATH:hsa04912]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04915 Estrogen signaling pathway [PATH:hsa04915]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04917 Prolactin signaling pathway [PATH:hsa04917]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04921 Oxytocin signaling pathway [PATH:hsa04921]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04926 Relaxin signaling pathway [PATH:hsa04926]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04935 Growth hormone synthesis, secretion and action [PATH:hsa04935]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04919 Thyroid hormone signaling pathway [PATH:hsa04919]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04928 Parathyroid hormone synthesis, secretion and action [PATH:hsa04928]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04916 Melanogenesis [PATH:hsa04916]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09153 Circulatory system
04270 Vascular smooth muscle contraction [PATH:hsa04270]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09156 Nervous system
04725 Cholinergic synapse [PATH:hsa04725]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04726 Serotonergic synapse [PATH:hsa04726]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04720 Long-term potentiation [PATH:hsa04720]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04730 Long-term depression [PATH:hsa04730]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
04722 Neurotrophin signaling pathway [PATH:hsa04722]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09158 Development and regeneration
04380 Osteoclast differentiation [PATH:hsa04380]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer [PATH:hsa05200]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05206 MicroRNAs in cancer [PATH:hsa05206]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05205 Proteoglycans in cancer [PATH:hsa05205]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05207 Chemical carcinogenesis - receptor activation [PATH:hsa05207]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05208 Chemical carcinogenesis - reactive oxygen species [PATH:hsa05208]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05230 Central carbon metabolism in cancer [PATH:hsa05230]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05231 Choline metabolism in cancer [PATH:hsa05231]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09162 Cancer: specific types
05210 Colorectal cancer [PATH:hsa05210]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05212 Pancreatic cancer [PATH:hsa05212]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05225 Hepatocellular carcinoma [PATH:hsa05225]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05226 Gastric cancer [PATH:hsa05226]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05214 Glioma [PATH:hsa05214]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05216 Thyroid cancer [PATH:hsa05216]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05221 Acute myeloid leukemia [PATH:hsa05221]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05220 Chronic myeloid leukemia [PATH:hsa05220]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05218 Melanoma [PATH:hsa05218]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05211 Renal cell carcinoma [PATH:hsa05211]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05219 Bladder cancer [PATH:hsa05219]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05215 Prostate cancer [PATH:hsa05215]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05213 Endometrial cancer [PATH:hsa05213]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05224 Breast cancer [PATH:hsa05224]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05223 Non-small cell lung cancer [PATH:hsa05223]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection [PATH:hsa05166]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05170 Human immunodeficiency virus 1 infection [PATH:hsa05170]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05161 Hepatitis B [PATH:hsa05161]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05160 Hepatitis C [PATH:hsa05160]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05164 Influenza A [PATH:hsa05164]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05163 Human cytomegalovirus infection [PATH:hsa05163]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05167 Kaposi sarcoma-associated herpesvirus infection [PATH:hsa05167]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05165 Human papillomavirus infection [PATH:hsa05165]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09171 Infectious disease: bacterial
05132 Salmonella infection [PATH:hsa05132]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05135 Yersinia infection [PATH:hsa05135]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09164 Neurodegenerative disease
05010 Alzheimer disease [PATH:hsa05010]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
05022 Pathways of neurodegeneration - multiple diseases [PATH:hsa05022]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09165 Substance dependence
05034 Alcoholism [PATH:hsa05034]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09167 Endocrine and metabolic disease
04934 Cushing syndrome [PATH:hsa04934]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance [PATH:hsa01521]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
01522 Endocrine resistance [PATH:hsa01522]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Protein kinases [BR:hsa01001]
Serine/threonine kinases: STE group
STE7 family
5604 MAP2K1; mitogen-activated protein kinase kinase 1 K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
[ BRITE | KEGG2 | KEGG ]