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ENTRY	nt06260
Name	Colorectal cancer
Category	Disease view; Cancer
Pathway	hsa05210 Colorectal cancer
Disease	H00020 Colorectal cancer
Display	drug-target relation   disease type

ERK signaling                           D1  |         N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1                           D1  |     N00276    EGF* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00229    TGFA → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00230    TGFA* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00277    EREG → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00278    EREG* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00279    AREG → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00280    AREG* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |     N00041        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK                           D1  |         N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00281    EGF* → EGFR → PI3K → PIP3 → AKT N00231    TGFA → EGFR → PI3K → PIP3 → AKT → MTOR N00232    TGFA* → EGFR → PI3K → PIP3 → AKT N00282    EREG → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00283    EREG* → EGFR → PI3K → PIP3 → AKT → S6K N00284    AREG → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00285    AREG* → EGFR → PI3K → PIP3 → AKT → S6K N00042        EGFR* → PI3K → PIP3 → AKT → MTOR → S6K N00030    EGF → EGFR → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00032                    (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD Other RAS signaling N00103    EGF → EGFR → GRB2 → SOS → RAS → RALGDS → RAL N00104                    KRAS* → RALGDS → RAL WNT signaling N00056    WNT → (FZD+LRP5/6) → (DVL+FRAT) ⊣ (GSK3B+AXIN+APC) ⊣ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1) N00057                (GSK3B+AXIN) ⌿ APC* ⌿ CTNNB1 → TCF/LEF ⇒ (BIRC5,MYC,CCND1) N00058                (GSK3B+AXIN+APC) ⌿ CTNNB1* → TCF/LEF ⇒ (BIRC5,MYC,CCND1) TGFB signaling N00063    TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00064        (TGFBR2*+TGFBR1) ⌿ (SMAD2,SMAD3) N00065        (TGFBR2+TGFBR1) ⌿ (SMAD2*,SMAD3) Apoptosis N00098    (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00099            BAX* ⌿ CYCS N00101    CASP3 → DCC → (CASP9+APPL1) → CASP3 N00102    CASP3 ⌿ DCC* ⌿ (CASP9+APPL1) Transcription N00115    TP53* ⌿ (CDKN1A,GADD45,BAX..

		Drug name
D1	D10604	Binimetinib (JAN/USAN/INN)