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ENTRY	nt06272
Name	Prostate cancer
Category	Disease view; Cancer
Pathway	hsa05215 Prostate cancer
Disease	H00024 Prostate cancer
Display	drug-target relation   disease type

PI3K signaling N00220    PTEN ⊣ PIP3 → AKT N00052    PTEN* ⌿ PIP3 → AKT N00082        NKX3-1* ⌿ AKT ⊣ BAD Nuclear receptor signaling       D1,D2,D3,D4,D5,D6  |     N00083    (T,DHT) → AR ⇒ KLK3 N00085    (T,DHT,E2,P4,FLUT,.. → AR* ⇒ KLK3 N00084    (T,DHT) → AR* ⇒ KLK3 Cell cycle N00091    (SCF+SKP2) ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F N00093        CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F Transcription N00128    TMPRSS2-ERG ⇒ (PLAU,PLAT,MMP3,MM.. N00129    TMPRSS2-ERG ⫤ SPINT1 N00130    TMPRSS2-ETV5 ⇒ (PLAU,MMP9)

		Drug name
D1	D00586	Flutamide (JP18/USP/INN)
D2	D00961	Bicalutamide (JP18/USP/INN)
D3	D00965	Nilutamide (USAN/INN)
D4	D10218	Enzalutamide (JAN/USAN)
D5	D11040	Apalutamide (JAN/INN)
D6	D11045	Darolutamide (JAN/USAN/INN)