KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:esh00010 esh01200 esh01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:esh00010 esh01200 esh01230 esh01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:esh00010 esh00020 esh01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:esh00010 esh00020 esh00620 esh00785 esh01200 esh01210 esh01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:esh00020 esh01200 esh01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:esh00020 esh01200 esh01210 esh01230 esh01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:esh00020 esh01200 esh01210 esh01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:esh00030 esh01200 esh01100 esh01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:esh00030 esh01200 esh01100 esh01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:esh00030 esh01200 esh01230 esh01100 esh01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:esh00030 esh00230 esh01200 esh01230 esh01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:esh00030 esh01200 esh01100 esh01120]

Other carbohydrate metabolism
M00631 D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:esh00040 esh00030 esh01100]
M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:esh00040 esh00030 esh01100]
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:esh00052 esh01100]
M00552 D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P [PATH:esh00052 esh01100]
M00550 Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:esh00053 esh01100 esh01120]
M00854 Glycogen biosynthesis, glucose-1P => glycogen/starch [PATH:esh00500 esh01100]
M00855 Glycogen degradation, glycogen => glucose-6P [PATH:esh00500 esh01100]
M00565 Trehalose biosynthesis, D-glucose 1P => trehalose [PATH:esh00500 esh01100 esh01110]
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:esh00520 esh01250 esh01100]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:esh00520 esh00052 esh01250 esh01100]
M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:esh00520 esh01250 esh01100]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:esh00520 esh01100]
M00012 Glyoxylate cycle [PATH:esh00630 esh01200 esh01100 esh01110]

Energy metabolism
Carbon fixation
M00168 CAM (Crassulacean acid metabolism), dark [PATH:esh00620 esh00710 esh01200 esh01100 esh01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:esh00430 esh00620 esh00720 esh01200 esh01100 esh01120]

Methane metabolism
Nitrogen metabolism
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH:esh00910 esh01100 esh01120]
M00530 Dissimilatory nitrate reduction, nitrate => ammonia [PATH:esh00910 esh01100 esh01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:esh00920 esh01100 esh01120]

Photosynthesis
ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:esh00190 esh01100]
M00149 Succinate dehydrogenase, prokaryotes [PATH:esh00190 esh01100]
M00150 Fumarate reductase, prokaryotes [PATH:esh00190 esh01100]
M00153 Cytochrome bd ubiquinol oxidase [PATH:esh00190]
M00417 Cytochrome o ubiquinol oxidase [PATH:esh00190 esh01100]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:esh00190 esh01100]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:esh00061 esh01212 esh01100]
M00083 Fatty acid biosynthesis, elongation [PATH:esh00061 esh01212 esh01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:esh00061 esh00071 esh01212 esh01100]
M00087 beta-Oxidation [PATH:esh00071 esh01212 esh01100]

Sterol biosynthesis
Lipid metabolism
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:esh00564 esh01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:esh00230 esh01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:esh00230 esh01232 esh01240 esh01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:esh00230 esh01232 esh01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:esh00230 esh00240 esh01232 esh01100]

Pyrimidine metabolism
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:esh00240 esh01240 esh01100]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:esh00240 esh01232 esh01240 esh01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:esh00240 esh01232 esh01100]
M00939 Pyrimidine degradation, uracil => 3-hydroxypropanoate [PATH:esh00240 esh01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:esh00260 esh00680 esh01200 esh01230 esh01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:esh00260 esh01230 esh01100 esh01110]
M00621 Glycine cleavage system [PATH:esh00260 esh00630 esh00785 esh01200 esh01100]
M00555 Betaine biosynthesis, choline => betaine [PATH:esh00260 esh01100]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:esh00270 esh00920 esh01200 esh01230 esh01100 esh01110]
M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:esh00260 esh00270 esh01230 esh01100]
M00017 Methionine biosynthesis, aspartate => homoserine => methionine [PATH:esh00270 esh01230 esh01100]
M00034 Methionine salvage pathway [PATH:esh00270 esh01100]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:esh00290 esh00770 esh01210 esh01230 esh01100 esh01110]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:esh00290 esh01230 esh01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:esh00290 esh01210 esh01230 esh01100 esh01110]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:esh00300 esh01230 esh01100]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:esh00220 esh01210 esh01230 esh01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:esh00220 esh01230 esh01100]
M00015 Proline biosynthesis, glutamate => proline [PATH:esh00330 esh01230 esh01100]
M00970 Proline degradation, proline => glutamate [PATH:esh00330 esh01100]
M00879 Arginine succinyltransferase pathway, arginine => glutamate [PATH:esh00330 esh01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:esh00330 esh01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:esh00340 esh01230 esh01100 esh01110]
M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate [PATH:esh00340 esh01100]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:esh00400 esh01230 esh01100 esh01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:esh00400 esh01230 esh01100 esh01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:esh00400 esh01230 esh01100 esh01110]
M00025 Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:esh00400 esh01230 esh01100]
M00533 Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:esh00350 esh01220 esh01100 esh01120]

Other amino acid metabolism
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:esh00480 esh01240 esh01100]

Glycan metabolism
Glycan biosynthesis
Glycosaminoglycan metabolism
Lipopolysaccharide metabolism
M00060 KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type [PATH:esh00540 esh01100]
M00063 CMP-KDO biosynthesis [PATH:esh00540 esh01250 esh01100]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis [PATH:esh00540 esh01250 esh01100]

Other polysaccharide metabolism
Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:esh00730 esh01240 esh01100]
M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:esh00730 esh01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:esh00740 esh01240 esh01100 esh01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:esh00750 esh01240 esh01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:esh00760 esh01240 esh01100]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:esh00770 esh01240 esh01100 esh01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:esh00770 esh01240 esh01100]
M00572 Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP [PATH:esh00780 esh01240 esh01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:esh00780 esh01240 esh01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:esh00785 esh01240 esh01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:esh00790 esh00670 esh01240 esh01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:esh00790 esh01240 esh01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:esh00860 esh01240 esh01100 esh01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:esh00860 esh01240 esh01100 esh01110]
M00924 Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide [PATH:esh00860 esh01240 esh01100]
M00122 Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin [PATH:esh00860 esh01240 esh01100]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:esh00130 esh01240 esh01100 esh01110]
M00116 Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol [PATH:esh00130 esh01240 esh01100 esh01110]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:esh00900 esh01100 esh01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:esh00900 esh01100 esh01110]

Plant terpenoid biosynthesis
Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
M00918 Aerobactin biosynthesis, lysine => aerobactin [PATH:esh00997 esh01100 esh01110]

Xenobiotics biodegradation
Aromatics degradation
M00878 Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:esh00360 esh01100 esh01120]

Gene set
Pathogenicity
Drug resistance
M00696 Multidrug resistance, efflux pump AcrEF-TolC

Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00615 Nitrate assimilation
M00616 Sulfate-sulfur assimilation