KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:pae00010 pae01200 pae01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:pae00010 pae01200 pae01230 pae01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:pae00010 pae00020 pae01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pae00010 pae00020 pae00620 pae01200 pae01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:pae00020 pae01200 pae01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:pae00020 pae01200 pae01210 pae01230 pae01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:pae00020 pae01200 pae01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:pae00030 pae01200 pae01100 pae01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:pae00030 pae01200 pae01100 pae01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:pae00030 pae01200 pae01230 pae01100 pae01120]
M00580 Pentose phosphate pathway, archaea, fructose 6P => ribose 5P [PATH:pae00030 pae01200 pae01230 pae01100 pae01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:pae00030 pae00230 pae01200 pae01230 pae01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:pae00030 pae01200 pae01100 pae01120]

Other carbohydrate metabolism
M00631 D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:pae00040 pae00030 pae01100]
M00061 D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:pae00040 pae00030 pae01100]
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:pae00052 pae01100]
M00552 D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P [PATH:pae00052 pae01100]
M00854 Glycogen biosynthesis, glucose-1P => glycogen/starch [PATH:pae00500 pae01100]
M00855 Glycogen degradation, glycogen => glucose-6P [PATH:pae00500 pae01100]
M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:pae00520 pae01250 pae01100]
M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:pae00520 pae00052 pae01250 pae01100]
M00909 UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:pae00520 pae01250 pae01100]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:pae00520 pae01100]
M00012 Glyoxylate cycle [PATH:pae00630 pae01200 pae01100 pae01110]
M00373 Ethylmalonyl pathway [PATH:pae00630 pae01200 pae01100 pae01120]
M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:pae00280 pae00630 pae00640 pae01200 pae01100]

Energy metabolism
Carbon fixation
M00167 Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P [PATH:pae01200 pae01100 pae01120]
M00168 CAM (Crassulacean acid metabolism), dark [PATH:pae00620 pae01200 pae01100 pae01120]
M00169 CAM (Crassulacean acid metabolism), light [PATH:pae00620 pae01200 pae01100 pae01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:pae00430 pae00620 pae01200 pae01100 pae01120]

Methane metabolism
M00345 Formaldehyde assimilation, ribulose monophosphate pathway [PATH:pae00030 pae00680 pae01200 pae01230 pae01100 pae01120]

Nitrogen metabolism
M00175 Nitrogen fixation, nitrogen => ammonia [PATH:pae00910 pae01100 pae01120]
M00531 Assimilatory nitrate reduction, nitrate => ammonia [PATH:pae00910 pae01100 pae01120]
M00529 Denitrification, nitrate => nitrogen [PATH:pae00910 pae01100 pae01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:pae00920 pae01100 pae01120]
M00595 Thiosulfate oxidation by SOX complex, thiosulfate => sulfate [PATH:pae00920 pae01100 pae01120]

Photosynthesis
ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:pae00190]
M00149 Succinate dehydrogenase, prokaryotes [PATH:pae00190]
M00150 Fumarate reductase, prokaryotes [PATH:pae00190]
M00151 Cytochrome bc1 complex respiratory unit [PATH:pae00190]
M00155 Cytochrome c oxidase, prokaryotes [PATH:pae00190]
M00153 Cytochrome bd ubiquinol oxidase [PATH:pae00190]
M00417 Cytochrome o ubiquinol oxidase [PATH:pae00190]
M00416 Cytochrome aa3-600 menaquinol oxidase [PATH:pae00190]
M00156 Cytochrome c oxidase, cbb3-type [PATH:pae00190]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:pae00190]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:pae00061 pae01212 pae01100]
M00083 Fatty acid biosynthesis, elongation [PATH:pae00061 pae01212 pae01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:pae00061 pae00071 pae01212 pae01100]
M00087 beta-Oxidation [PATH:pae00071 pae01212 pae01100]

Sterol biosynthesis
Lipid metabolism
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:pae00564 pae01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pae00230 pae01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pae00230 pae01232 pae01240 pae01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pae00230 pae01232 pae01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pae00230 pae00240 pae01232 pae01100]
M00958 Adenine ribonucleotide degradation, AMP => Urate [PATH:pae00230 pae01232 pae01100]
M00959 Guanine ribonucleotide degradation, GMP => Urate [PATH:pae00230 pae01232 pae01100]

Pyrimidine metabolism
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:pae00240 pae01232 pae01240 pae01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:pae00240 pae01232 pae01100]
M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [PATH:pae00240 pae01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:pae00260 pae00680 pae01200 pae01230 pae01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pae00260 pae01230 pae01100 pae01110]
M00555 Betaine biosynthesis, choline => betaine [PATH:pae00260 pae01100]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:pae00270 pae00920 pae01200 pae01230 pae01100 pae01110]
M00338 Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pae00260 pae00270 pae01230 pae01100]
M00017 Methionine biosynthesis, aspartate => homoserine => methionine [PATH:pae00270 pae01230 pae01100]
M00034 Methionine salvage pathway [PATH:pae00270 pae01100]
M00035 Methionine degradation [PATH:pae00270 pae01100]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:pae00290 pae00770 pae01210 pae01230 pae01100 pae01110]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:pae00290 pae01230 pae01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:pae00290 pae01210 pae01230 pae01100 pae01110]
M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:pae00280 pae01100]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:pae00300 pae01230 pae01100]
M00525 Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:pae00300 pae01230 pae01100]
M00526 Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:pae00300 pae01230 pae01100]
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:pae00300 pae01230 pae01100 pae01110]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:pae00220 pae01210 pae01230 pae01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:pae00220 pae01230 pae01100]
M00015 Proline biosynthesis, glutamate => proline [PATH:pae00330 pae01230 pae01100]
M00879 Arginine succinyltransferase pathway, arginine => glutamate [PATH:pae00330 pae01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:pae00330 pae01100]
M00134 Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:pae00330 pae01100]
M00135 GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:pae00330 pae01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:pae00340 pae01230 pae01100 pae01110]
M00045 Histidine degradation, histidine => N-formiminoglutamate => glutamate [PATH:pae00340 pae01100]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:pae00400 pae01230 pae01100 pae01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:pae00400 pae01230 pae01100 pae01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:pae00400 pae01230 pae01100 pae01110]
M00040 Tyrosine biosynthesis, chorismate => arogenate => tyrosine [PATH:pae00400 pae01230 pae01100 pae01110]
M00044 Tyrosine degradation, tyrosine => homogentisate [PATH:pae00350 pae01100]
M00533 Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:pae00350 pae01220 pae01100 pae01120]

Other amino acid metabolism
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:pae00480 pae01240 pae01100]
M00947 D-Arginine racemization, D-arginine => L-arginine [PATH:pae00470 pae01100]
M00948 Hydroxyproline degradation, trans-4-hydroxy-L-proline => 2-oxoglutarate [PATH:pae00470 pae01100]
M00949 Staphylopine biosynthesis, L-histidine => staphylopine [PATH:pae00470 pae01100]

Glycan metabolism
Glycan biosynthesis
Glycosaminoglycan metabolism
Lipopolysaccharide metabolism
M00060 KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type [PATH:pae00540 pae01100]
M00063 CMP-KDO biosynthesis [PATH:pae00540 pae01250 pae01100]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis [PATH:pae00540 pae01250 pae01100]

Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:pae00730 pae01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:pae00740 pae01240 pae01100 pae01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:pae00750 pae01240 pae01100]
M00916 Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P [PATH:pae00750 pae01240 pae01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:pae00760 pae01240 pae01100]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:pae00770 pae01240 pae01100 pae01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:pae00770 pae01240 pae01100]
M00572 Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP [PATH:pae00780 pae01240 pae01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:pae00780 pae01240 pae01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:pae00785 pae01240 pae01100]
M00883 Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2 [PATH:pae00785 pae01240 pae01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:pae00790 pae00670 pae01240 pae01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:pae00790 pae01240 pae01100]
M00140 C1-unit interconversion, prokaryotes [PATH:pae00670 pae01240 pae01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:pae00860 pae01240 pae01100 pae01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:pae00860 pae01240 pae01100 pae01110]
M00926 Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme [PATH:pae00860 pae01240 pae01100]
M00924 Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide [PATH:pae00860 pae01240 pae01100]
M00122 Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin [PATH:pae00860 pae01240 pae01100]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:pae00130 pae01240 pae01100 pae01110]
M00116 Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol [PATH:pae00130 pae01240 pae01100 pae01110]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:pae00900 pae01100 pae01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:pae00900 pae01100 pae01110]

Plant terpenoid biosynthesis
Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
M00793 dTDP-L-rhamnose biosynthesis [PATH:pae00521 pae00523 pae00541 pae01250 pae01100 pae01110]

Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
M00835 Pyocyanine biosynthesis, chorismate => pyocyanine [PATH:pae00405 pae01100 pae01110]

Xenobiotics biodegradation
Aromatics degradation
M00551 Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:pae00362 pae00622 pae01220 pae01100 pae01120]
M00637 Anthranilate degradation, anthranilate => catechol [PATH:pae00627 pae01100 pae01120]
M00568 Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:pae00362 pae01220 pae01100 pae01120]
M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:pae00360 pae01220 pae01100 pae01120]

Gene set
Pathogenicity
Drug resistance
M00851 Carbapenem resistance [PATH:pae01501]
M00745 Imipenem resistance, repression of porin OprD
M00718 Multidrug resistance, efflux pump MexAB-OprM
M00639 Multidrug resistance, efflux pump MexCD-OprJ
M00641 Multidrug resistance, efflux pump MexEF-OprN
M00642 Multidrug resistance, efflux pump MexJK-OprM
M00643 Multidrug resistance, efflux pump MexXY-OprM
M00769 Multidrug resistance, efflux pump MexPQ-OpmE
M00700 Multidrug resistance, efflux pump AbcA
M00705 Multidrug resistance, efflux pump MepA

Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00615 Nitrate assimilation
M00616 Sulfate-sulfur assimilation