KEGG    Biosynthesis of enediyne antibiotics - Reference pathway
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Enediyne natural products are potent antitumor antibiotics produced by a variety of Actinomycetes. Enediyne has a unique structure consisting of three building blocks: aromatic, sugar and enediyne core. The enediyne core contains two acetylenic groups conjugated to a double bond in a 9- or 10-membered ring, and it is synthesized by an iterative type I polyketide synthase and other tailoring proteins [MD:M00824 M00825]. The 10-membered enediyne such as calicheamicin also contains an allylic trisulfide group, which acts as a trigger for diradical formation. This diagram shows the biosynthesis of C-1027, maduropeptin, neocarzinostatin, kedarcidin and calicheamicin. Some aromatic moieties are synthesized via iterative type I polyketide synthases, and others are derived from chorismate and aromatic amino acids such as tyrosine and azatyrosine [MD:M00829 M00830 M00831 M00834 M00826 M00827 M00828 M00832]. Finally, the aromatic and sugar building blocks are attached to the enediyne core by acyltransferases, condensation enzymes and glucosyltransferases [MD:M00833].
Scale: 100%
  • Pathway modules
    • Biosynthesis of terpenoids and polyketides
      • Enediyne biosynthesis
        • M00824 9-membered enediyne core biosynthesis
        • M00825 10-membered enediyne core biosynthesis
        • M00826 C-1027 benzoxazolinate moiety biosynthesis
        • M00827 C-1027 beta-amino acid moiety biosynthesis
        • M00828 Maduropeptin beta-hydroxy acid moiety biosynthesis
        • M00829 3,6-Dimethylsalicylyl-CoA biosynthesis
        • M00830 Neocarzinostatin naphthoate moiety biosynthesis
        • M00831 Kedarcidin 2-hydroxynaphthoate moiety biosynthesis
        • M00832 Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis
        • M00834 Calicheamicin orsellinate moiety biosynthesis
        • M00833 Calicheamicin biosynthesis