KEGG    Tetracycline biosynthesis - Streptomyces avermitilis
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Tetracyclines are aromatic polyketide antibiotics produced by Streptomyces species via type II polyketide synthases (PKSs). Tetracyclines contain a linear tetracyclic skeleton, which is formed from a malonamate starter unit and malonyl-CoA extender units through a common polyketide pathway [MD:M00778]. This diagram shows biosynthesis of naturally occurring tetracyclines (tetracycline, oxytetracycline and chlortetracycline) via a common intermediate anhydrotetracycline [MD:M00780 M00823].
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  • Pathway modules
    • Biosynthesis of terpenoids and polyketides
      • Type II polyketide biosynthesis
        • M00778 Type II polyketide backbone biosynthesis
        • M00780 Tetracycline/oxytetracycline biosynthesis
        • M00823 Chlortetracycline biosynthesis