Disease genes and drug targets in KEGG pathways

KEGG pathway maps

• Global and overview maps
  • H D  01200  Carbon metabolism
    H D  01210  2-Oxocarboxylic acid metabolism
    H D  01212  Fatty acid metabolism
    H D  01230  Biosynthesis of amino acids
    H D  01232  Nucleotide metabolism
    H D  01250  Biosynthesis of nucleotide sugars
    H D  01240  Biosynthesis of cofactors
    H    01320  Sulfur cycle
    
• Carbohydrate metabolism
  • H D  00010  Glycolysis / Gluconeogenesis
    H D  00020  Citrate cycle (TCA cycle)
    H    00030  Pentose phosphate pathway
    H D  00040  Pentose and glucuronate interconversions
    H D  00051  Fructose and mannose metabolism
    H D  00052  Galactose metabolism
    H D  00053  Ascorbate and aldarate metabolism
    H D  00500  Starch and sucrose metabolism
    H D  00620  Pyruvate metabolism
    H D  00630  Glyoxylate and dicarboxylate metabolism
    H D  00640  Propanoate metabolism
    H D  00650  Butanoate metabolism
    H D  00562  Inositol phosphate metabolism
    
• Energy metabolism
  • H D  00190  Oxidative phosphorylation
    H D  00910  Nitrogen metabolism
    H    00920  Sulfur metabolism
    
• Lipid metabolism
  • H D  00061  Fatty acid biosynthesis
    H    00062  Fatty acid elongation
    H D  00071  Fatty acid degradation
    H D  00100  Steroid biosynthesis
    H D  00120  Primary bile acid biosynthesis
    H D  00140  Steroid hormone biosynthesis
    H D  00561  Glycerolipid metabolism
    H D  00564  Glycerophospholipid metabolism
    H D  00565  Ether lipid metabolism
    H D  00600  Sphingolipid metabolism
    H D  00590  Arachidonic acid metabolism
    H D  00591  Linoleic acid metabolism
    H D  00592  alpha-Linolenic acid metabolism
    H    01040  Biosynthesis of unsaturated fatty acids
    
• Nucleotide metabolism
  • H D  00230  Purine metabolism
    H D  00240  Pyrimidine metabolism
    
• Amino acid metabolism
  • H D  00250  Alanine, aspartate and glutamate metabolism
    H D  00260  Glycine, serine and threonine metabolism
    H D  00270  Cysteine and methionine metabolism
    H D  00280  Valine, leucine and isoleucine degradation
    H    00290  Valine, leucine and isoleucine biosynthesis
    H D  00310  Lysine degradation
    H D  00220  Arginine biosynthesis
    H D  00330  Arginine and proline metabolism
    H D  00340  Histidine metabolism
    H D  00350  Tyrosine metabolism
    H D  00360  Phenylalanine metabolism
    H D  00380  Tryptophan metabolism
    H D  00400  Phenylalanine, tyrosine and tryptophan biosynthesis
    
• Metabolism of other amino acids
  • H D  00410  beta-Alanine metabolism
    H D  00430  Taurine and hypotaurine metabolism
    H    00440  Phosphonate and phosphinate metabolism
    H D  00450  Selenocompound metabolism
    H D  00470  D-Amino acid metabolism
    H D  00480  Glutathione metabolism
    
• Glycan biosynthesis and metabolism
  • H D  00520  Amino sugar and nucleotide sugar metabolism
    H    00541  Biosynthesis of various nucleotide sugars
    H D  00510  N-Glycan biosynthesis
    H    00513  Various types of N-glycan biosynthesis
    H    00512  Mucin type O-glycan biosynthesis
    H    00515  Mannose type O-glycan biosynthesis
    H    00514  Other types of O-glycan biosynthesis
    H    00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    H    00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    H    00533  Glycosaminoglycan biosynthesis - keratan sulfate
    H D  00531  Glycosaminoglycan degradation
    H D  00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
    H    00601  Glycosphingolipid biosynthesis - lacto and neolacto series
    H D  00603  Glycosphingolipid biosynthesis - globo and isoglobo series
    H    00604  Glycosphingolipid biosynthesis - ganglio series
    H D  00511  Other glycan degradation
    
• Metabolism of cofactors and vitamins
  • H D  00730  Thiamine metabolism
    H    00740  Riboflavin metabolism
    H    00750  Vitamin B6 metabolism
    H D  00760  Nicotinate and nicotinamide metabolism
    H D  00770  Pantothenate and CoA biosynthesis
    H    00780  Biotin metabolism
    H    00785  Lipoic acid metabolism
    H D  00790  Folate biosynthesis
    H D  00670  One carbon pool by folate
    H D  00830  Retinol metabolism
    H D  00860  Porphyrin metabolism
    H D  00130  Ubiquinone and other terpenoid-quinone biosynthesis
    
• Metabolism of terpenoids and polyketides
  • H D  00900  Terpenoid backbone biosynthesis
    
• Biosynthesis of other secondary metabolites
  • H D  00232  Caffeine metabolism
    H D  00524  Neomycin, kanamycin and gentamicin biosynthesis
    
• Xenobiotics biodegradation and metabolism
  • H D  00980  Metabolism of xenobiotics by cytochrome P450
    H D  00982  Drug metabolism - cytochrome P450
    H D  00983  Drug metabolism - other enzymes
    

• Transcription
  • H D  03020  RNA polymerase
    H D  03022  Basal transcription factors
    H D  03040  Spliceosome
    
• Translation
  • H    03010  Ribosome
    H D  00970  Aminoacyl-tRNA biosynthesis
    H D  03013  Nucleocytoplasmic transport
    H D  03015  mRNA surveillance pathway
    H D  03008  Ribosome biogenesis in eukaryotes
    
• Folding, sorting and degradation
  • H    03060  Protein export
    H D  04141  Protein processing in endoplasmic reticulum
    H    04130  SNARE interactions in vesicular transport
    H D  04120  Ubiquitin mediated proteolysis
    H    04122  Sulfur relay system
    H D  03050  Proteasome
    H    03018  RNA degradation
    
• Replication and repair
  • H D  03030  DNA replication
    H D  03410  Base excision repair
    H D  03420  Nucleotide excision repair
    H    03430  Mismatch repair
    H D  03440  Homologous recombination
    H    03450  Non-homologous end-joining
    H D  03460  Fanconi anemia pathway
    
• Chromosome
  • H D  03082  ATP-dependent chromatin remodeling
    H D  03083  Polycomb repressive complex
    
• Information processing in viruses
  • H D  03250  Viral life cycle - HIV-1
    H D  03260  Virion - Human immunodeficiency virus
    H D  03271  Virion - Rotavirus
    H D  03264  Virion - Flavivirus and Alphavirus
    H D  03265  Virion - Ebolavirus, Lyssavirus and Morbillivirus
    H D  03273  Virion - Lassa virus and SFTS virus
    H D  03272  Virion - Hepatitis viruses
    H D  03266  Virion - Herpesvirus
    H D  03267  Virion - Adenovirus
    

• Membrane transport
  • H D  02010  ABC transporters
    
• Signal transduction
  • H D  04010  MAPK signaling pathway
    H D  04012  ErbB signaling pathway
    H D  04014  Ras signaling pathway
    H D  04015  Rap1 signaling pathway
    H D  04310  Wnt signaling pathway
    H D  04330  Notch signaling pathway
    H D  04340  Hedgehog signaling pathway
    H D  04350  TGF-beta signaling pathway
    H D  04390  Hippo signaling pathway
    H D  04392  Hippo signaling pathway - multiple species
    H D  04370  VEGF signaling pathway
    H D  04371  Apelin signaling pathway
    H D  04630  JAK-STAT signaling pathway
    H D  04064  NF-kappa B signaling pathway
    H D  04668  TNF signaling pathway
    H D  04066  HIF-1 signaling pathway
    H D  04068  FoxO signaling pathway
    H D  04020  Calcium signaling pathway
    H D  04070  Phosphatidylinositol signaling system
    H D  04072  Phospholipase D signaling pathway
    H D  04071  Sphingolipid signaling pathway
    H D  04024  cAMP signaling pathway
    H D  04022  cGMP-PKG signaling pathway
    H D  04151  PI3K-Akt signaling pathway
    H D  04152  AMPK signaling pathway
    H D  04150  mTOR signaling pathway
    
• Signaling molecules and interaction
  • H D  04080  Neuroactive ligand-receptor interaction
    H D  04082  Neuroactive ligand signaling
    H D  04081  Hormone signaling
    H D  04060  Cytokine-cytokine receptor interaction
    H D  04061  Viral protein interaction with cytokine and cytokine receptor
    H D  04512  ECM-receptor interaction
    H D  04514  Cell adhesion molecules
    

• Transport and catabolism
  • H D  04144  Endocytosis
    H D  04145  Phagosome
    H D  04142  Lysosome
    H D  04146  Peroxisome
    H D  04140  Autophagy - animal
    H D  04136  Autophagy - other
    H D  04137  Mitophagy - animal
    H D  04148  Efferocytosis
    
• Cell growth and death
  • H D  04110  Cell cycle
    H D  04114  Oocyte meiosis
    H D  04210  Apoptosis
    H D  04215  Apoptosis - multiple species
    H D  04216  Ferroptosis
    H D  04217  Necroptosis
    H D  04115  p53 signaling pathway
    H D  04218  Cellular senescence
    
• Cellular community - eukaryotes
  • H D  04510  Focal adhesion
    H D  04520  Adherens junction
    H D  04530  Tight junction
    H D  04540  Gap junction
    H D  04550  Signaling pathways regulating pluripotency of stem cells
    
• Cell motility
  • H D  04814  Motor proteins
    H D  04820  Cytoskeleton in muscle cells
    H D  04810  Regulation of actin cytoskeleton
    

• Immune system
  • H D  04640  Hematopoietic cell lineage
    H D  04610  Complement and coagulation cascades
    H D  04611  Platelet activation
    H D  04613  Neutrophil extracellular trap formation
    H D  04620  Toll-like receptor signaling pathway
    H D  04621  NOD-like receptor signaling pathway
    H D  04622  RIG-I-like receptor signaling pathway
    H D  04623  Cytosolic DNA-sensing pathway
    H D  04625  C-type lectin receptor signaling pathway
    H D  04650  Natural killer cell mediated cytotoxicity
    H D  04612  Antigen processing and presentation
    H D  04660  T cell receptor signaling pathway
    H D  04658  Th1 and Th2 cell differentiation
    H D  04659  Th17 cell differentiation
    H D  04657  IL-17 signaling pathway
    H D  04662  B cell receptor signaling pathway
    H D  04664  Fc epsilon RI signaling pathway
    H D  04666  Fc gamma R-mediated phagocytosis
    H D  04670  Leukocyte transendothelial migration
    H D  04672  Intestinal immune network for IgA production
    H D  04062  Chemokine signaling pathway
    
• Endocrine system
  • H D  04911  Insulin secretion
    H D  04910  Insulin signaling pathway
    H D  04922  Glucagon signaling pathway
    H D  04923  Regulation of lipolysis in adipocytes
    H D  04920  Adipocytokine signaling pathway
    H D  03320  PPAR signaling pathway
    H D  04929  GnRH secretion
    H D  04912  GnRH signaling pathway
    H D  04913  Ovarian steroidogenesis
    H D  04915  Estrogen signaling pathway
    H D  04914  Progesterone-mediated oocyte maturation
    H D  04917  Prolactin signaling pathway
    H D  04921  Oxytocin signaling pathway
    H D  04926  Relaxin signaling pathway
    H D  04935  Growth hormone synthesis, secretion and action
    H D  04918  Thyroid hormone synthesis
    H D  04919  Thyroid hormone signaling pathway
    H D  04928  Parathyroid hormone synthesis, secretion and action
    H D  04916  Melanogenesis
    H D  04924  Renin secretion
    H D  04614  Renin-angiotensin system
    H D  04925  Aldosterone synthesis and secretion
    H D  04927  Cortisol synthesis and secretion
    
• Circulatory system
  • H D  04260  Cardiac muscle contraction
    H D  04261  Adrenergic signaling in cardiomyocytes
    H D  04270  Vascular smooth muscle contraction
    
• Digestive system
  • H D  04970  Salivary secretion
    H D  04971  Gastric acid secretion
    H D  04972  Pancreatic secretion
    H D  04976  Bile secretion
    H D  04973  Carbohydrate digestion and absorption
    H D  04974  Protein digestion and absorption
    H D  04975  Fat digestion and absorption
    H D  04979  Cholesterol metabolism
    H D  04977  Vitamin digestion and absorption
    H D  04981  Folate transport and metabolism
    H    04980  Cobalamin transport and metabolism
    H D  04978  Mineral absorption
    
• Excretory system
  • H D  04962  Vasopressin-regulated water reabsorption
    H D  04960  Aldosterone-regulated sodium reabsorption
    H D  04961  Endocrine and other factor-regulated calcium reabsorption
    H D  04964  Proximal tubule bicarbonate reclamation
    H D  04966  Collecting duct acid secretion
    
• Nervous system
  • H D  04724  Glutamatergic synapse
    H D  04727  GABAergic synapse
    H D  04725  Cholinergic synapse
    H D  04728  Dopaminergic synapse
    H D  04726  Serotonergic synapse
    H D  04720  Long-term potentiation
    H D  04730  Long-term depression
    H D  04723  Retrograde endocannabinoid signaling
    H D  04721  Synaptic vesicle cycle
    H D  04722  Neurotrophin signaling pathway
    
• Sensory system
  • H D  04744  Phototransduction
    H D  04740  Olfactory transduction
    H D  04742  Taste transduction
    H D  04750  Inflammatory mediator regulation of TRP channels
    
• Development and regeneration
  • H D  04360  Axon guidance
    H D  04380  Osteoclast differentiation
    
• Aging
  • H D  04211  Longevity regulating pathway
    H D  04213  Longevity regulating pathway - multiple species
    
• Environmental adaptation
  • H D  04710  Circadian rhythm
    H D  04713  Circadian entrainment
    H D  04714  Thermogenesis
    

• Cancer: overview
  • H D  05200  Pathways in cancer
    H D  05202  Transcriptional misregulation in cancer
    H D  05206  MicroRNAs in cancer
    H D  05205  Proteoglycans in cancer
    H D  05204  Chemical carcinogenesis - DNA adducts
    H D  05207  Chemical carcinogenesis - receptor activation
    H D  05208  Chemical carcinogenesis - reactive oxygen species
    H D  05203  Viral carcinogenesis
    H D  05230  Central carbon metabolism in cancer
    H D  05231  Choline metabolism in cancer
    H D  05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
    
• Cancer: specific types
  • H D  05210  Colorectal cancer
    H D  05212  Pancreatic cancer
    H D  05225  Hepatocellular carcinoma
    H D  05226  Gastric cancer
    H D  05214  Glioma
    H D  05216  Thyroid cancer
    H D  05221  Acute myeloid leukemia
    H D  05220  Chronic myeloid leukemia
    H D  05217  Basal cell carcinoma
    H D  05218  Melanoma
    H D  05211  Renal cell carcinoma
    H D  05219  Bladder cancer
    H D  05215  Prostate cancer
    H D  05213  Endometrial cancer
    H D  05224  Breast cancer
    H D  05222  Small cell lung cancer
    H D  05223  Non-small cell lung cancer
    
• Infectious disease: viral
  • H D  05166  Human T-cell leukemia virus 1 infection
    H D  05170  Human immunodeficiency virus 1 infection
    H D  05161  Hepatitis B
    H D  05160  Hepatitis C
    H D  05171  Coronavirus disease - COVID-19
    H D  05164  Influenza A
    H D  05162  Measles
    H D  05168  Herpes simplex virus 1 infection
    H D  05163  Human cytomegalovirus infection
    H D  05167  Kaposi sarcoma-associated herpesvirus infection
    H D  05169  Epstein-Barr virus infection
    H D  05165  Human papillomavirus infection
    
• Infectious disease: bacterial
  • H D  05110  Vibrio cholerae infection
    H D  05120  Epithelial cell signaling in Helicobacter pylori infection
    H D  05130  Pathogenic Escherichia coli infection
    H D  05132  Salmonella infection
    H D  05131  Shigellosis
    H D  05135  Yersinia infection
    H D  05133  Pertussis
    H D  05134  Legionellosis
    H D  05150  Staphylococcus aureus infection
    H D  05152  Tuberculosis
    H D  05100  Bacterial invasion of epithelial cells
    
• Infectious disease: parasitic
  • H D  05146  Amoebiasis
    H D  05144  Malaria
    H D  05145  Toxoplasmosis
    H D  05140  Leishmaniasis
    H D  05142  Chagas disease
    H D  05143  African trypanosomiasis
    
• Immune disease
  • H D  05310  Asthma
    H D  05322  Systemic lupus erythematosus
    H D  05323  Rheumatoid arthritis
    H D  05320  Autoimmune thyroid disease
    H D  05321  Inflammatory bowel disease
    H D  05330  Allograft rejection
    H D  05332  Graft-versus-host disease
    H D  05340  Primary immunodeficiency
    
• Neurodegenerative disease
  • H D  05010  Alzheimer disease
    H D  05012  Parkinson disease
    H D  05014  Amyotrophic lateral sclerosis
    H D  05016  Huntington disease
    H D  05017  Spinocerebellar ataxia
    H D  05020  Prion disease
    H D  05022  Pathways of neurodegeneration - multiple diseases
    
• Substance dependence
  • H D  05030  Cocaine addiction
    H D  05031  Amphetamine addiction
    H D  05032  Morphine addiction
    H D  05033  Nicotine addiction
    H D  05034  Alcoholism
    
• Cardiovascular disease
  • H D  05417  Lipid and atherosclerosis
    H D  05418  Fluid shear stress and atherosclerosis
    H D  05410  Hypertrophic cardiomyopathy
    H D  05412  Arrhythmogenic right ventricular cardiomyopathy
    H D  05414  Dilated cardiomyopathy
    H D  05415  Diabetic cardiomyopathy
    H D  05416  Viral myocarditis
    
• Endocrine and metabolic disease
  • H D  04930  Type II diabetes mellitus
    H D  04940  Type I diabetes mellitus
    H D  04950  Maturity onset diabetes of the young
    H D  04936  Alcoholic liver disease
    H D  04932  Non-alcoholic fatty liver disease
    H D  04931  Insulin resistance
    H D  04933  AGE-RAGE signaling pathway in diabetic complications
    H D  04934  Cushing syndrome
    
• Drug resistance: antineoplastic
  • H D  01521  EGFR tyrosine kinase inhibitor resistance
    H D  01524  Platinum drug resistance
    H D  01523  Antifolate resistance
    H D  01522  Endocrine resistance