Fatty acid biosynthesis

Building blocks

Carboxylic acids (R-COOH)
Starter unit Extension unit
Acetyl-CoA
Malonyl-CoA

Initiation

Acyl transferase (AT) Ketoacyl synthase (KS)
Acetyl-[acp]

+
Malonyl-[acp]

Acetoacetyl-[acp]

Elongation (General form)

Acyl-[acp]

+
Malonyl-[acp]

3-Oxoacyl-[acp]

3-Hydroxyacyl-[acp]

2,3-Dehydroacyl-[acp]

Acyl-[acp] (n+2)

Elongation (All steps)

Ketoacyl synthase (KS) Keto reductase (KR) Dehydratase (DH) Enoyl reductase (ER)
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Termination

Thio reductase (TE)

Palmitic acid (16:0)