| Entry | The KEGG DRUG database is a unified drug information resource for all prescription and OTC drugs in Japan, most prescription drugs in the USA, and many prescription drugs in Europe. Each entry is identified by the unique identifier called the D number ('D' followed by five-digit number) distinguishing the chemical structure or the chemical component, and contains manually curated information about target, metabolizing enzyme, and other interacting molecules. |
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| Name | The generic name and selected trade names of the drug. |
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Products Generic | Links to package insert information in DailyMed. |
| Formula | The molecular formula of the drug structure. |
| Exact mass | The exact mass of the drug structure. |
| Mol weight | The molecular weight of the drug structure. |
| Structure | The chemical structure (structural formula) of the drug is manually entered by KEGG and is stored in an MDL/MOL file (Mol file button) and a KCF file (KCF file button), the latter being used for chemical structure comparisons (DB search button). A GIF image of the chemical structure is shown here, and it can be viewed in a separate window by clicking on the image. Jmol and KegDraw buttons launches the Java programs Jmol and KegDraw, respectively, for viewing and manipulating the chemical structure. |
| Simcomp | The Neighbor button displays a list of similar chemical structures in the DRUG and COMPOUND databases, which are precomputed by SIMCOMP program. The list may be converted to a dendrogram from the Select menu. |
| Component | Chemical components when the drug consists of multiple ingredients. |
| Source | Biological source when the drug is derived from a natural product. |
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Sequence Type | Sequence data and type when the drug is a peptide, a polyketide or a nucleotide. |
| Class | Pharmacologic classes represented by KEGG DGROUP entries. |
| Remark | This field contains C/G/E numbers of identical entries in the COMPOUND/GLYCAN/ENVIRON databases, Therapeutic category in Japan, ATC code, Chemical structure group in the DGROUP database, as well as the list of related D numbers with product information in Japan (JP) or USA (US). |
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Efficacy Disease Type | Efficacy or activity of the drug, as well as the diseases indicated in drug labels. Diseases may be different in the English and Japanese versions due to the difference between the US (FDA) and Japanese drug labels. The Type subfield contains special drug types such as monoclonal antibody and antisense oligonucleogide. |
| Comment | Free text comment. |
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Target Pathway | Target information of the drug with appropriate links to human genes and KEGG Orthology, as well as KEGG pathway maps that involve these targets. |
| Metabolism | Information about drug metabolizing enzymes and transporters. When distinction of major and minor enzymes/transporters can be made, they are separated by a semicolon rather than a comma. |
| Interaction | Other interaction information, such as CYP induction and inhibition, etc. Adverse interactions/reactions can be examined with the DDI search button, searching against the drug-drug interaction data maintained at KEGG. |
| Biosynthesis | Links to the KEGG pathway maps for biosynthesis of this drug as a natural product. |
| Structure map | Links to the KEGG drug structure maps showing the histroy of drug development. |
| Other map | Links to the other KEGG pathway maps that contain this drug. |
| Brite | This field contains drug classifications in the BRITE database. The "BRITE hierarchy" buttom may also be used to display these classifications. |
| Other DBs | Links to outside databases. |
| LinkDB | 'All DBs' button in this field retrieves all available links to related database entries in the LinkDB system. At GenomeNet this field does not appear; instead a list of actual links is displayed on the right. |
| KCF data | The KCF (KEGG Chemical Function) representation of the chemical structure can be displayed here. It contains the KEGG atom type information for use in chemical structure comparisons. |