KEGG Network Variation Map

Map The KEGG NETWORK database is a collection of network elements indicating variations of signaling and other interaction/reaction networks in human pathways. A network variation map consists of related network elements in terms of signaling pathways, metabolic pathways, diseases, etc.
Notation
Network element Coloring
Reference network Green
Variant network Red/Purple/Blue/None
Drug-target relation Navy

Node Identifier Coloring
Human reference gene/protein hsa ID None
Human gene variant variant ID Red
Viral or other pathogen gene/protein K number Purple
Environmental factor C number Blue
Metabolite C number None
Drug D number Navy

Type Edge Text Symbol
Signaling network Activation (single- or multi-step) -> →
Inhibition (single- or multi-step) -| ⊣
Complex formation == ＝
Missing interaction // ⌿
Gain of function -^ ↗
Expression (single-step) => ⇒
Repression (single-step) =| ⫤
Metabolic network Enzyme-enzyme relation >> ⇉
Substrate-enzyme relation -- —
Enzyme-product relation -> →
Missing reaction // ⌿
Enhanced reaction -^ ↗