MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iML1515 [2].
Target metabolite : gdpddman_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (71 of 82: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 45
  Gene deletion: b4467 b2836 b3399 b4269 b0493 b3588 b3003 b3011 b4384 b2744 b0871 b2926 b2407 b1004 b3713 b1109 b0046 b3236 b1638 b1982 b4139 b0675 b2361 b0261 b2799 b3945 b1602 b0507 b2913 b4381 b3915 b1727 b2975 b0114 b3603 b0529 b2492 b0904 b1300 b2954 b3029 b1380 b3662 b2285 b1009   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.447969 (mmol/gDw/h)
  Minimum Production Rate : 0.220770 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_o2_e : 36.874194
  EX_glc__D_e : 10.000000
  EX_nh4_e : 5.944354
  EX_pi_e : 0.873641
  EX_so4_e : 0.112808
  EX_k_e : 0.087440
  EX_fe3_e : 0.007197
  EX_mg2_e : 0.003886
  EX_ca2_e : 0.002332
  EX_cl_e : 0.002332
  EX_cu2_e : 0.000318
  EX_mn2_e : 0.000310
  EX_zn2_e : 0.000153
  EX_ni2_e : 0.000145
  EX_cobalt2_e : 0.000011

Product: (mmol/gDw/h)
  EX_h2o_e : 52.311023
  EX_co2_e : 37.471417
  EX_h_e : 4.788113
  EX_etoh_e : 0.302891
  Auxiliary production reaction : 0.220764
  EX_ade_e : 0.000501
  DM_5drib_c : 0.000301
  DM_4crsol_c : 0.000100

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics (2023).
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

---

Last updated: 09-Jul-2025
Contact