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ENTRY	nt06033
Name	Glycine, serine and arginine metabolism
Category	Pathway view; Amino acid metabolism
Pathway	hsa00260 Glycine, serine and threonine metabolism hsa00330 Arginine and proline metabolism hsa00670 One carbon pool by folate
Module	hsa_M00621 Glycine cleavage system hsa_M00020 Serine biosynthesis, glycerate-3P => serine hsa_M00974 Betaine metabolism, animals, betaine => glycine hsa_M00047 Creatine pathway hsa_M00972 Proline metabolism hsa_M00970 Proline degradation, proline => glutamate
Disease	H00191 Glycine encephalopathy H00849 Cerebral creatine deficiency syndrome H00190 Hyperprolinemia
Display	drug-target relation   disease type

N01613    Gly+Lipoyl-H − GLDC ⇉ AMT → MTHF+Dihydrolipoyl..     GCE1     GLDC*     GCE2         AMT* N01610    Dihydrolipoyl-H − DLD → Lipoyl-H N01611    GCSH = (GLDC+AMT+DLD)     MMDS7 GCSH*   N01791    Ser+THF − SHMT → Gly+MTHF     NEDCASB     SHMT2*   N01608    3-PGA − PHGDH ⇉ PSAT1 ⇉ PSPH → Ser     PHGDH deficiency/NLS     PHGDH*     PSAT deficiency/NLS         PSAT1*     PSPH deficiency             PSPH*   N01789    GB − BHMT ⇉ DMGDH → Sarcosine − (SARDH,PIPOX) → Gly     DMGDHD         DMGDH*     Sarcosinemia             Sarcosine↗   SARDH*   N01612    Arg+Gly − GATM ⇉ GAMT → Cr − CK → Crn     CCDS3     GATM*     CCDS2         GAMT* N01615    Cr − SLC6A8 → Cr(intracellular)     CCDS1     SLC6A8*   N01618    Orn − OAT ⇉ PYCR → Pro     Ornithinaemia     OAT* N01622    Pro − PRODH ⇉ ALDH4A1 → Glu     HYRPRO1     PRODH*     HYRPRO2         ALDH4A1*   N01623    Orn − ODC1 → Put − SRM ⇉ SMS → Spm     NEDABA     ODC1*     SRS                 SMS*

		Disease name	Disease category
GCE1	H00191	Nonketotic hyperglycinemia	Inherited metabolic disorder
GCE2	H00191	Nonketotic hyperglycinemia	Inherited metabolic disorder
MMDS7	H01894	Multiple mitochondrial dysfunctions syndrome	Inherited metabolic disorder, Mitochondrial disease
NEDCASB	H02470	Neurodevelopmental disorder with structural brain abnormalities	Congenital malformation
PHGDH deficiency/NLS	H01079	3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency	Inherited metabolic disorder
	H02117	Neu-Laxova syndrome	Inherited metabolic disorder
PSAT deficiency/NLS	H01082	Phosphoserine aminotransferase deficiency	Inherited metabolic disorder
	H02117	Neu-Laxova syndrome	Inherited metabolic disorder
PSPH deficiency	H02116	Phosphoserine phosphatase deficiency	Inherited metabolic disorder
DMGDHD	H01003	Dimethylglycine dehydrogenase deficiency	Inherited metabolic disorder
Sarcosinemia	H02657	Sarcosinemia	Inherited metabolic disorder
CCDS3	H00849	Cerebral creatine deficiency syndrome	Inherited metabolic disorder
CCDS2	H00849	Cerebral creatine deficiency syndrome	Inherited metabolic disorder
CCDS1	H00849	Cerebral creatine deficiency syndrome	Inherited metabolic disorder
Ornithinaemia	H00189	Ornithinaemia	Inherited metabolic disorder
HYRPRO1	H00190	Hyperprolinemia	Inherited metabolic disorder
HYRPRO2	H00190	Hyperprolinemia	Inherited metabolic disorder
NEDABA	H02470	Neurodevelopmental disorder with structural brain abnormalities	Congenital malformation
SRS	H00597	Snyder-Robinson syndrome	Congenital malformation