KEGG    Network variation - Human T-cell leukemia virus 1 (HTLV-1)
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ENTRYnt06160
NameHuman T-cell leukemia virus 1 (HTLV-1)
CategoryDisease view; Viral infection
Pathwayhsa05166 Human T-cell leukemia virus 1 infection
GenomeT40003
DiseaseH00009 Adult T-cell leukemia
Display drug-target relation   disease type
PI3K signaling
N00390    EGF→EGFR→PI3K→PIP3→AKT→IKK→NFKBIA→NFKB
N00501      TAX→PI3K
N00220        PTEN⊣PIP3→AKT
N00502    TAX⊣DLG1→PTEN
TGFB signaling
N00063    TGFB→(TGFBR2+TGFBR1)→(SMAD2,SMAD3)=SMAD4
N00507      TAX⊣(SMAD2,SMAD3)
JAK-STAT signaling
N00053    Cytokine→Receptor→JAK→STAT⇒PIM1
N00491    P12→IL2RB/G→JAK1/3→STAT5⇒IL2
Calcium signaling
N00487    IGH→(LYN,SYK)→(BTK,BLNK)→PLCG2→IP3→Ca2+→CALM=CN→NFAT
N00490          P12=(CALR,CANX)→Ca2+
TNF signaling
N00446    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAK1+TAB1/2)→MKK4/7→JNK→AP1
N00503            TAX→(MAPK8,MAPK9,MAPK1..→JUN⇒MMP7
N00151    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
N00504        TAX→IKK→NFKBIA→NFKB
N00505    CD40LG→CD40→(TRAF2+TRAF3)→NIK→IKKA→(NFKB2+RELB)
N00506        TAX=IKBKG→IKKA→(NFKB2+RELB)
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)→(MHCI+B2M)
N00492        P12⊣(MHCI+B2M)
Cell cycle
N00069          CDKN2A⊣(CCND+CDK4/6)→RB1⌿E2F
N00494        TAX⊣CDKN2A
N00090      (MYC+MAX)⊣ZBTB17⇒CDKN2B⊣(CCND+CDK4/6)→RB1⌿E2F
N00495        TAX⊣CDKN2B
N00499    (ATM,ATR)→CHEK1→TP53⇒CDKN1A⊣(CDK1+CCNB)
N00500    TAX⊣CHEK1
N00493      MAD1L1→(MAD2L1/2+BUB1B+BU..⊣(ANAPC+CDC20)⊣PTTG⊣ESPL1
N00222    TAX⊣MAD1L1
N00221        TAX→(ANAPC+CDC20)⊣PTTG⊣ESPL1
Transcription
N00489    P30II→(MYC+TRRAP+KAT5)⇒CCND2
N00497      TAX⊣TP53⇒CDKN1A⊣(CDK2+CCNE)→RB1⌿E2F
N00498        TAX⊣CDKN1A⊣(CDK2+CCNE)→RB1⌿E2F
N00508    TAX→NFYB⇒MHCII
N00509    TAX→SRF⇒(FOS,FOSL1,EGR1,EG..
N00510    TAX→CREB3⇒CCND1
N00511    TAX⊣E47⇒(POLB,LCK,BAX,CDKN..
N00512    TAX⊣MYC⇒TERT